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Extrathymic Development of V11 T Cells in Placenta During Pregnancy and Their Possible Physiological Role

Masahiko Yamasaki^*, Takahisa Sasho^*,, Hideshige Moriya, Masamoto Kanno, Michishige Harada^*, Noriaki Kamada^*, Eiko Shimizu^*, Toshinori Nakayama^* and Masaru Taniguchi^1,*

^* Core Research for Evolutional Science and Technology, Department of Molecular Immunology, Graduate School of Medicine, and Department of Orthopedics, School of Medicine, Chiba University, Chiba, Japan; and Department of Immunology and Parasitology, School of Medicine, Hiroshima University, Hiroshima, Japan

The molecular and cellular mechanisms of the feto-maternal immune responses in the placenta in connection with natural abortion remain unclear. In this report we provide evidence that V11 T cells developed in the placenta may be responsible for the induction of natural abortion. The majority of V11 TCRs detected during pregnancy showed a consensus motif in the CDR3 region, similar to that of anti-GM3 TCR clones, and were of maternal origin. V11 TCRs were found in the middle to late stages of gestation due to de novo generation in the placenta, not to migration from the maternal side, as evidenced by the significant increases in the out-of-frame V11 TCR mRNA and the copy number of circular DNA generated by V11 gene rearrangements. Furthermore, administration of anti-V11 Ab to pregnant mice resulted in a significant decrease in the incidence of fetal demise, suggesting that V11 T cells detected in the placenta develop extrathymically and are involved in natural abortion.

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