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Ludwig Institute for Cancer Research, Brussels Branch and the Experimental Medicine Unit, Christian de Duve Institute of Cellular Pathology, Université de Louvain, Brussels, Belgium
The class II cytokine receptor family includes the receptors for
IFN-
, IFN-
, IL-10, and IL-10-related T cell-derived inducible
factor/IL-22. By screening genomic DNA databases, we identified a gene
encoding a protein of 231 aa, showing 33 and 34% amino acid identity
with the extracellular domains of the IL-22 receptor and of the
IL-20R/cytokine receptor family 2-8, respectively, but lacking the
transmembrane and cytoplasmic domains. A lower but significant sequence
identity was found with other members of this family such as the IL-10R
(29%), cytokine receptor family 2-4/IL-10R (30%), tissue factor
(26%), and the four IFN receptor chains (23–25%). This gene is
located on chromosome 6q24, at 35 kb from the IFNGR1
gene, and is expressed in various tissues with maximal expression in
breast, lungs, and colon. The recombinant protein was found to bind
IL-10-related T cell-derived inducible factor/IL-22, and to inhibit the
activity of this cytokine on hepatocytes and intestinal epithelial
cells. We propose to name this natural cytokine antagonist IL-22BP for
IL-22 binding protein.
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