| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599;
Department of Pathology, University of Florida, Gainesville, FL 32610; and
The Jackson Laboratory, Bar Harbor, ME 04609
Several studies have provided indirect evidence in support of a
role for 
cell-specific Th2 cells in regulating insulin-dependent
diabetes (IDDM). Whether a homogeneous population of Th2 cells having a
defined cell Ag specificity can prevent or suppress autoimmune
diabetes is still unclear. In fact, recent studies have demonstrated
that cell-specific Th2 cell clones can induce IDDM. In this study
we have established Th cell clones specific for glutamic acid
decarboxylase 65 (GAD65), a known cell autoantigen, from young
unimmunized nonobese diabetic (NOD) mice. Adoptive transfer of a
GAD65-specific Th2 cell clone (characterized by the secretion of IL-4,
IL-5, and IL-10, but not IFN-
or TGF-) into 2- or 12-wk-old NOD
female recipients prevented the progression of insulitis and subsequent
development of overt IDDM. This prevention was marked by the
establishment of a Th2-like cytokine profile in response to a panel of
cell autoantigens in cultures established from the spleen and
pancreatic lymph nodes of recipient mice. The immunoregulatory function
of a given Th cell clone was dependent on the relative levels of
IFN- vs IL-4 and IL-10 secreted. These results provide direct
evidence that cell-specific Th2 cells can indeed prevent and
suppress autoimmune diabetes in NOD mice.
This article has been cited by other articles:
|
|
 |
|
  L. Li, B. Wang, J. A. Frelinger, and R. Tisch T-Cell Promiscuity in Autoimmune Diabetes Diabetes, August 1, 2008; 57(8): 2099 - 2106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Chen, G. Han, J. Wang, R. Wang, R. Xu, B. Shen, J. Qian, and Y. Li Induction of Active Tolerance and Involvement of CD1d-Restricted Natural Killer T Cells in Anti-CD3 F(ab')2 Treatment-Reversed New-Onset Diabetes in Nonobese Diabetic Mice Am. J. Pathol., April 1, 2008; 172(4): 972 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. You, B. Leforban, C. Garcia, J.-F. Bach, J. A. Bluestone, and L. Chatenoud Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment PNAS, April 10, 2007; 104(15): 6335 - 6340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tian, D. Zekzer, Y. Lu, H. Dang, and D. L. Kaufman B Cells Are Crucial for Determinant Spreading of T Cell Autoimmunity among beta Cell Antigens in Diabetes-Prone Nonobese Diabetic Mice J. Immunol., February 15, 2006; 176(4): 2654 - 2661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. D. Dai, K. P. Jensen, A. Lehuen, E. L. Masteller, J. A. Bluestone, D. B. Wilson, and E. E. Sercarz A Peptide of Glutamic Acid Decarboxylase 65 Can Recruit and Expand a Diabetogenic T Cell Clone, BDC2.5, in the Pancreas J. Immunol., September 15, 2005; 175(6): 3621 - 3627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Han, Y. Li, J. Wang, R. Wang, G. Chen, L. Song, R. Xu, M. Yu, X. Wu, J. Qian, et al. Active Tolerance Induction and Prevention of Autoimmune Diabetes by Immunogene Therapy Using Recombinant Adenoassociated Virus Expressing Glutamic Acid Decarboxylase 65 Peptide GAD500-585 J. Immunol., April 15, 2005; 174(8): 4516 - 4524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. You, C. Chen, W.-H. Lee, T. Brusko, M. Atkinson, and C.-P. Liu Presence of Diabetes-Inhibiting, Glutamic Acid Decarboxylase-Specific, IL-10-Dependent, Regulatory T Cells in Naive Nonobese Diabetic Mice J. Immunol., December 1, 2004; 173(11): 6777 - 6785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-K. Kim, K. V. Tarbell, M. Sanna, M. Vadeboncoeur, T. Warganich, M. Lee, M. Davis, and H. O. McDevitt Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells PNAS, September 28, 2004; 101(39): 14204 - 14209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chen, W.-H. Lee, P. Yun, P. Snow, and C.-P. Liu Induction of Autoantigen-Specific Th2 and Tr1 Regulatory T Cells and Modulation of Autoimmune Diabetes J. Immunol., July 15, 2003; 171(2): 733 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tian, A. P. Olcott, and D. L. Kaufman Antigen-Based Immunotherapy Drives the Precocious Development of Autoimmunity J. Immunol., December 1, 2002; 169(11): 6564 - 6569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Quintana, P. Carmi, and I. R. Cohen DNA Vaccination with Heat Shock Protein 60 Inhibits Cyclophosphamide-Accelerated Diabetes J. Immunol., November 15, 2002; 169(10): 6030 - 6035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. V. Tarbell, M. Lee, E. Ranheim, C. C. Chao, M. Sanna, S.-K. Kim, P. Dickie, L. Teyton, M. Davis, and H. McDevitt CD4+ T Cells from Glutamic Acid Decarboxylase (GAD)65-specific T Cell Receptor Transgenic Mice Are Not Diabetogenic and Can Delay Diabetes Transfer J. Exp. Med., August 19, 2002; 196(4): 481 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Friedline, C. P. Wong, D. A. Steeber, T. F. Tedder, and R. Tisch L-Selectin Is Not Required for T Cell-Mediated Autoimmune Diabetes J. Immunol., March 15, 2002; 168(6): 2659 - 2666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Kim, M. Zhang, B. P. Vistica, C.-C. Chan, D.-F. Shen, E. F. Wawrousek, and I. Gery Induction of Ocular Inflammation by T-Helper Lymphocytes Type 2 Invest. Ophthalmol. Vis. Sci., March 1, 2002; 43(3): 758 - 765. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
