| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Receptors1
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140
Our laboratory has previously demonstrated that the
ligation of phagocytic receptors on macrophages can influence cytokine
production. In this study, we examine the cytokine responses to
multiple inflammatory stimuli following Fc
R ligation. Macrophages
were stimulated in vitro with LPS, lipoteichoic acid, CD40 ligand, or
low molecular mass hyaluronic acid. All of these stimuli were
proinflammatory in character, inducing the production of high levels of
IL-12, but only modest amounts of IL-10. The coligation of FcR along
with these stimuli resulted in an anti-inflammatory profile,
abrogating IL-12 production and inducing high levels of IL-10. The
modulation of these two cytokines occurred by two independent
mechanisms. Whereas the abrogation of IL-12 biosynthesis was a property
shared by several macrophage receptors, the induction of IL-10 was
specific to the FcR. The biological relevance of these observations
was examined in murine models of endotoxemia, in which FcR ligation
induced the rapid production of IL-10 and prevented IL-12 synthesis.
Mice could be passively immunized with Abs to LPS to reverse
inflammatory cytokine production, and the transfer of macrophages whose
FcR had been ligated could rescue mice from lethal endotoxemia.
Thus, the ligation of the macrophage FcR can be exploited to prevent
inappropriate inflammatory cytokine responses.
This article has been cited by other articles:
|
|
 |
|
  H. Huang, G. R. Ostroff, C. K. Lee, J. P. Wang, C. A. Specht, and S. M. Levitz Distinct Patterns of Dendritic Cell Cytokine Release Stimulated by Fungal {beta}-Glucans and Toll-Like Receptor Agonists Infect. Immun., May 1, 2009; 77(5): 1774 - 1781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Nair, Y. Du, J. G. Perrigoue, C. Zaph, J. J. Taylor, M. Goldschmidt, G. P. Swain, G. D. Yancopoulos, D. M. Valenzuela, A. Murphy, et al. Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung J. Exp. Med., April 13, 2009; 206(4): 937 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Edwards, X. Zhang, and D. M. Mosser The Expression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor by Regulatory Macrophages J. Immunol., February 15, 2009; 182(4): 1929 - 1939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Maglione, J. Xu, A. Casadevall, and J. Chan Fc{gamma} Receptors Regulate Immune Activation and Susceptibility during Mycobacterium tuberculosis Infection J. Immunol., March 1, 2008; 180(5): 3329 - 3338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-E. Ghia, F. Galeazzi, D. C. Ford, C. M. Hogaboam, B. A. Vallance, and S. Collins Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus Am J Physiol Gastrointest Liver Physiol, March 1, 2008; 294(3): G770 - G777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Forthal, G. Landucci, J. Bream, L. P. Jacobson, T. B. Phan, and B. Montoya Fc{gamma}RIIa Genotype Predicts Progression of HIV Infection J. Immunol., December 1, 2007; 179(11): 7916 - 7923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Polumuri, V. Y. Toshchakov, and S. N. Vogel Role of Phosphatidylinositol-3 Kinase in Transcriptional Regulation of TLR-Induced IL-12 and IL-10 by Fc{gamma} Receptor Ligation in Murine Macrophages J. Immunol., July 1, 2007; 179(1): 236 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P L E M van Lent, A B Blom, L Grevers, A Sloetjes, and W B van den Berg Toll-like receptor 4 induced Fc{gamma}R expression potentiates early onset of joint inflammation and cartilage destruction during immune complex arthritis: Toll-like receptor 4 largely regulates Fc{gamma}R expression by interleukin 10 Ann Rheum Dis, March 1, 2007; 66(3): 334 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Rodriguez, C. Mold, M. Kataranovski, J. A. Hutt, L. L. Marnell, J. S. Verbeek, and T. W. Du Clos C-Reactive Protein-Mediated Suppression of Nephrotoxic Nephritis: Role of Macrophages, Complement, and Fc{gamma} Receptors J. Immunol., January 1, 2007; 178(1): 530 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Edwards, X. Zhang, K. A. Frauwirth, and D. M. Mosser Biochemical and functional characterization of three activated macrophage populations J. Leukoc. Biol., December 1, 2006; 80(6): 1298 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. D. Iankov, M. Pandey, M. Harvey, G. E. Griesmann, M. J. Federspiel, and S. J. Russell Immunoglobulin g antibody-mediated enhancement of measles virus infection can bypass the protective antiviral immune response. J. Virol., September 1, 2006; 80(17): 8530 - 8540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-J. Huang, Y.-C. Yang, Y.-S. Lin, J.-H. Huang, H.-S. Liu, T.-M. Yeh, S.-H. Chen, C.-C. Liu, and H.-Y. Lei The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection. J. Immunol., March 1, 2006; 176(5): 2825 - 2832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. W. Verreck, T. de Boer, D. M. L. Langenberg, L. van der Zanden, and T. H. M. Ottenhoff Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-{gamma}- and CD40L-mediated costimulation J. Leukoc. Biol., February 1, 2006; 79(2): 285 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Fronhofer, M. R. Lennartz, and D. J. Loegering Role of PKC isoforms in the Fc{gamma}R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages J. Leukoc. Biol., February 1, 2006; 79(2): 408 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Hamerman and L. L. Lanier Inhibition of Immune Responses by ITAM-Bearing Receptors Sci. Signal., January 31, 2006; 2006(320): re1 - re1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Mann, D. Wolfe, E. Latz, D. Golenbock, A. Preston, and E. T. Harvill Comparative Toll-Like Receptor 4-Mediated Innate Host Defense to Bordetella Infection Infect. Immun., December 1, 2005; 73(12): 8144 - 8152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lucas, X. Zhang, V. Prasanna, and D. M. Mosser ERK Activation Following Macrophage Fc{gamma}R Ligation Leads to Chromatin Modifications at the IL-10 Locus J. Immunol., July 1, 2005; 175(1): 469 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Scotton, F. O. Martinez, M. J. Smelt, M. Sironi, M. Locati, A. Mantovani, and S. Sozzani Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1{beta} System by IL-13 J. Immunol., January 15, 2005; 174(2): 834 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Casadevall and L.-a. Pirofski New Concepts in Antibody-Mediated Immunity Infect. Immun., November 1, 2004; 72(11): 6191 - 6196. [Full Text] [PDF]
|
|
|
|
|
|
P. B. Mann, K. D. Elder, M. J. Kennett, and E. T. Harvill Toll-Like Receptor 4-Dependent Early Elicited Tumor Necrosis Factor Alpha Expression Is Critical for Innate Host Defense against Bordetella bronchiseptica Infect. Immun., November 1, 2004; 72(11): 6650 - 6658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Xiong, H. Li, Y. Chen, J. Zhao, and J. C. Unkeless Interaction of TRAF6 with MAST205 Regulates NF-{kappa}B Activation and MAST205 Stability J. Biol. Chem., October 15, 2004; 279(42): 43675 - 43683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Whitsett, C. J. Bachurski, K. C. Barnes, P. A. Bunn Jr., L. M. Case, D. N. Cook, D. Crooks, M. W. Duncan, L. Dwyer-Nield, R. C. Elston, et al. Functional Genomics of Lung Disease Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2/S1): S1 - S81. [Full Text] [PDF]
|
|
|
|
|
|
T. H. Sulahian, P. A. Pioli, K. Wardwell, and P. M. Guyre Cross-linking of Fc{gamma}R triggers shedding of the hemoglobin-haptoglobin scavenger receptor CD163 J. Leukoc. Biol., July 1, 2004; 76(1): 271 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Morrison, C. B. Wilson, M. Ray, and P. H. Correll Macrophage-Stimulating Protein, the Ligand for the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase, Inhibits IL-12 Production by Primary Peritoneal Macrophages Stimulated with IFN-{gamma} and Lipopolysaccharide J. Immunol., February 1, 2004; 172(3): 1825 - 1832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Esnault and J. S. Malter Hyaluronic Acid or TNF-{alpha} Plus Fibronectin Triggers Granulocyte Macrophage-Colony-Stimulating Factor mRNA Stabilization in Eosinophils Yet Engages Differential Intracellular Pathways and mRNA Binding Proteins J. Immunol., December 15, 2003; 171(12): 6780 - 6787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Colmenares, P. E. Kima, E. Samoff, L. Soong, and D. McMahon-Pratt Perforin and Gamma Interferon Are Critical CD8+ T-Cell-Mediated Responses in Vaccine-Induced Immunity against Leishmania amazonensis Infection Infect. Immun., June 1, 2003; 71(6): 3172 - 3182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. N. Gantner, R. M. Simmons, S. J. Canavera, S. Akira, and D. M. Underhill Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2 J. Exp. Med., May 5, 2003; 197(9): 1107 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Mosser The many faces of macrophage activation J. Leukoc. Biol., February 1, 2003; 73(2): 209 - 212. [Full Text] [PDF]
|
|
|
|
|
|
C. Mold, W. Rodriguez, B. Rodic-Polic, and T. W. Du Clos C-Reactive Protein Mediates Protection from Lipopolysaccharide Through Interactions With Fc{gamma}R J. Immunol., December 15, 2002; 169(12): 7019 - 7025. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Anderson, J. S. Gerber, and D. M. Mosser Modulating macrophage function with IgG immune complexes Innate Immunity, December 1, 2002; 8(6): 477 - 481. [Abstract] [PDF]
|
|
|
|
|
|
G. S. Deepe, Jr., and R. S. Gibbons Cellular and Molecular Regulation of Vaccination with Heat Shock Protein 60 from Histoplasma capsulatum Infect. Immun., July 1, 2002; 70(7): 3759 - 3767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Anderson and D. M. Mosser A novel phenotype for an activated macrophage: the type 2 activated macrophage J. Leukoc. Biol., July 1, 2002; 72(1): 101 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. K. Varma, C. Y. Lin, T. E. Toliver-Kinsky, and E. R. Sherwood Endotoxin-Induced Gamma Interferon Production: Contributing Cell Types and Key Regulatory Factors Clin. Vaccine Immunol., May 1, 2002; 9(3): 530 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Anderson and D. M. Mosser Cutting Edge: Biasing Immune Responses by Directing Antigen to Macrophage Fc{gamma} Receptors J. Immunol., April 15, 2002; 168(8): 3697 - 3701. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
