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*
Umeå Center for Molecular Pathogenesis, Umeå University, Umeå, Sweden; and
Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
This study aims to determine how the interaction of Ly49 receptors
with MHC class I molecules shapes the development of the Ly49
repertoire. We have examined the percentage of NK cells that expressed
Ly49A, Ly49G2, and Ly49D in single and double Ly49A/C-transgenic mice
on four different MHC backgrounds, H-2b, H-2d,
H-2b/d, and
2-microglobulin-/-. The results show that
the total numbers of NK cells were not different among the strains. The
prior expression of a Ly49 receptor capable of binding to self MHC
class I altered the percentage of NK cells expressing endogenous Ly49A,
Ly49G2, and Ly49D even in mice in which no MHC ligand was present for
the latter receptors. The NK cells in the Ly49-transgenic mice
expressed the same level of endogenous Ly49 receptors as wild-type mice
of a similar MHC background. In contrast, the number of NK T cells was
reduced in mice in which the Ly49 transgene could bind to a MHC class I
molecule. The onset of Ly49 receptor expression on NK cells during
ontogeny was not altered in the presence of transgenic Ly49 receptors.
These data support a sequential model and argue against a selection
model for Ly49 repertoire development on NK
cells.
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