| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Trudeau Institute, Saranac Lake, NY 12983
We had previously examined the factors that regulate the response
of OVA-specific TCR-transgenic CD8 T cells to the B16 OVA melanoma,
growing as lung metastases. We examine here whether the same parameters
operate for EG7, growing intradermally. Tc1 or Tc2 CD8 effector cells
from OT-1 mice were injected either mixed with the tumor or i.v. at day
0 or 7. Tc2 were one-fifth to one-tenth as effective as Tc1 when
injected with the tumor, in controlling tumor growth, but were only
1/20 to 1/100 injected i.v. Tc1 injected i.v. entered the draining
lymph nodes faster than Tc2 and caused a faster accumulation of host
cells. Both caused an abrupt termination of host cell entry into lymph
nodes and spleen after tumor elimination, but this occurred earlier for
Tc1 than for Tc2. Host responses were ineffective in the absence of
adoptive transfer but were essential after transfer. Perforin
expression in the donor cells plays no role in adoptively transferred
Tc1 or Tc2 control of the tumor, and neither IL-4 nor IL5 is needed for
Tc1 or Tc2 function. Tc1 cells from mice lacking IFN-
, however,
control tumor growth less well, whereas Tc2 effectors lacking IFN-
are unaffected. Tc1 from IFN--deficient mice attract fewer host
cells to the draining lymph node, whereas Tc1 cells from
perforin-deficient donors are unimpaired. We conclude that host cell
recruitment is a crucial element in adoptive immunotherapy. The
differences between the EG7 and the previous B16 melanoma model are
discussed.
This article has been cited by other articles:
|
|
 |
|
  E. Y. Kim, S.-J. Teh, J. Yang, M. T. Chow, and H.-S. Teh TNFR2-Deficient Memory CD8 T Cells Provide Superior Protection against Tumor Cell Growth J. Immunol., November 15, 2009; 183(10): 6051 - 6057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hamada, M. d. l. L. Garcia-Hernandez, J. B. Reome, S. K. Misra, T. M. Strutt, K. K. McKinstry, A. M. Cooper, S. L. Swain, and R. W. Dutton Tc17, a Unique Subset of CD8 T Cells That Can Protect against Lethal Influenza Challenge J. Immunol., March 15, 2009; 182(6): 3469 - 3481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Rabinovich, Y. Ye, T. Etto, J. Q. Chen, H. I. Levitsky, W. W. Overwijk, L. J. N. Cooper, J. Gelovani, and P. Hwu Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer PNAS, September 23, 2008; 105(38): 14342 - 14346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Zhang, A. Barber, and C. L. Sentman Chimeric NKG2D Modified T Cells Inhibit Systemic T-Cell Lymphoma Growth in a Manner Involving Multiple Cytokines and Cytotoxic Pathways Cancer Res., November 15, 2007; 67(22): 11029 - 11036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Mathers, O. A. Tckacheva, B. M. Janelsins, W. J. Shufesky, A. E. Morelli, and A. T. Larregina In Vivo Signaling through the Neurokinin 1 Receptor Favors Transgene Expression by Langerhans Cells and Promotes the Generation of Th1- and Tc1-Biased Immune Responses J. Immunol., June 1, 2007; 178(11): 7006 - 7017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Boissonnas, L. Fetler, I. S. Zeelenberg, S. Hugues, and S. Amigorena In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor J. Exp. Med., February 19, 2007; 204(2): 345 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Hollenbaugh and R. W. Dutton IFN-{gamma} Regulates Donor CD8 T Cell Expansion, Migration, and Leads to Apoptosis of Cells of a Solid Tumor. J. Immunol., September 1, 2006; 177(5): 3004 - 3011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D McKenzie, N. L Dudek, L. Mariana, M. M. Chong, J. A Trapani, T. W. Kay, and H. E Thomas Perforin and Fas induced by IFN{gamma} and TNF{alpha} mediate beta cell death by OT-I CTL Int. Immunol., June 1, 2006; 18(6): 837 - 846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Fadel, L. G. Cowell, S. Cao, D. A. Ozaki, T. B. Kepler, D. A. Steeber, and M. Sarzotti Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection Int. Immunol., February 1, 2006; 18(2): 249 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Olver, P. Groves, K. Buttigieg, E. S. Morris, M. L. Janas, A. Kelso, and N. Kienzle Tumor-Derived Interleukin-4 Reduces Tumor Clearance and Deviates the Cytokine and Granzyme Profile of Tumor-Induced CD8+ T Cells Cancer Res., January 1, 2006; 66(1): 571 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Gao, J. Tao, M. O. Li, D. Zhang, H. Chi, O. Henegariu, S. M. Kaech, R. J. Davis, R. A. Flavell, and Z. Yin JNK1 Is Essential for CD8+ T Cell-Mediated Tumor Immune Surveillance J. Immunol., November 1, 2005; 175(9): 5783 - 5789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Song, X. Tang, K. M. Harms, and M. Croft OX40 and Bcl-xL Promote the Persistence of CD8 T Cells to Recall Tumor-Associated Antigen J. Immunol., September 15, 2005; 175(6): 3534 - 3541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kienzle, S. Olver, K. Buttigieg, P. Groves, M. L. Janas, A. Baz, and A. Kelso Progressive Differentiation and Commitment of CD8+ T Cells to a Poorly Cytolytic CD8low Phenotype in the Presence of IL-4 J. Immunol., February 15, 2005; 174(4): 2021 - 2029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Hollenbaugh, J. Reome, M. Dobrzanski, and R. W. Dutton The Rate of the CD8-Dependent Initial Reduction in Tumor Volume Is Not Limited by Contact-Dependent Perforin, Fas Ligand, or TNF-Mediated Cytolysis J. Immunol., August 1, 2004; 173(3): 1738 - 1743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Moroz, C. Eppolito, Q. Li, J. Tao, C. H. Clegg, and P. A. Shrikant IL-21 Enhances and Sustains CD8+ T Cell Responses to Achieve Durable Tumor Immunity: Comparative Evaluation of IL-2, IL-15, and IL-21 J. Immunol., July 15, 2004; 173(2): 900 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lavergne, B. Combadiere, O. Bonduelle, M. Iga, J.-L. Gao, M. Maho, A. Boissonnas, P. M. Murphy, P. Debre, and C. Combadiere Fractalkine Mediates Natural Killer-Dependent Antitumor Responses in Vivo Cancer Res., November 1, 2003; 63(21): 7468 - 7474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Jung, J. E. Foley, A. A. Erdmann, M. A. Eckhaus, and D. H. Fowler CD3/CD28-costimulated T1 and T2 subsets: differential in vivo allosensitization generates distinct GVT and GVHD effects Blood, November 1, 2003; 102(9): 3439 - 3446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Caldwell, M. H. Ryan, E. McDuffie, and S. I. Abrams The Fas/Fas Ligand Pathway Is Important for Optimal Tumor Regression in a Mouse Model of CTL Adoptive Immunotherapy of Experimental CMS4 Lung Metastases J. Immunol., September 1, 2003; 171(5): 2402 - 2412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Hill, K. Van Gunst, and N. Sarvetnick Th1 and Th2 Pancreatic Inflammation Differentially Affects Homing of Islet-Reactive CD4 Cells in Nonobese Diabetic Mice J. Immunol., February 15, 2003; 170(4): 1649 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Dubey, H. Su, N. Adonai, S. Du, A. Rosato, J. Braun, S. S. Gambhir, and O. N. Witte Quantitative imaging of the T cell antitumor response by positron-emission tomography PNAS, February 4, 2003; 100(3): 1232 - 1237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Goldberg, P. Shrikant, and M. F. Mescher In Vivo Augmentation of Tumor-Specific CTL Responses by Class I/Peptide Antigen Complexes on Microspheres (Large Multivalent Immunogen) J. Immunol., January 1, 2003; 170(1): 228 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Fadel, D. A. Ozaki, and M. Sarzotti Enhanced Type 1 Immunity After Secondary Viral Challenge in Mice Primed as Neonates J. Immunol., September 15, 2002; 169(6): 3293 - 3300. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
