| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
Departments of
*
Pathobiology,
Medicine, and
Clinical Studies, University of Pennsylvania, Philadelphia, PA 19104; and
The Jackson Laboratory, Bar Harbor, ME 04609
The ability of various infections to suppress neoplastic growth
has been well documented. This phenomenon has been traditionally
attributed to infection-induced concomitant, cell-mediated antitumor
immunity. We found that infection with Toxoplasma gondii
effectively blocked neoplastic growth of a nonimmunogenic B16.F10
melanoma. Moreover, this effect was independent of cytotoxic T or NK
cells, production of NO by macrophages, or the function of the
cytokines IL-12 and TNF-
. These findings suggested that antitumor
cytotoxicity was not the primary mechanism of resistance. However,
infection was accompanied by strong, systemic suppression of
angiogenesis, both in a model system and inside the nascent tumor. This
suppression resulted in severe hypoxia and avascular necrosis that are
incompatible with progressive neoplastic growth. Our results identify
the suppression of tumor neovascularization as a novel mechanism
critical for infection-induced resistance to
tumors.
This article has been cited by other articles:
|
|
 |
|
  L. M. Jeys, R. J. Grimer, S. R. Carter, R. M Tillman, and A. Abudu Post Operative Infection and Increased Survival in Osteosarcoma Patients: Are They Associated? Ann. Surg. Oncol., October 1, 2007; 14(10): 2887 - 2895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. X. Lascelles, W. S. Dernell, M. T. Correa, M. Lafferty, C. M. Devitt, C. A. Kuntz, R. C. Straw, and S. J. Withrow Improved Survival Associated With Postoperative Wound Infection in Dogs Treated With Limb-Salvage Surgery for Osteosarcoma Ann. Surg. Oncol., December 1, 2005; 12(12): 1073 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Thamm, I. D. Kurzman, I. King, Z. Li, M. Sznol, R. R. Dubielzig, D. M. Vail, and E. G. MacEwen Systemic Administration of an Attenuated, Tumor-Targeting Salmonella typhimurium to Dogs with Spontaneous Neoplasia: Phase I Evaluation Clin. Cancer Res., July 1, 2005; 11(13): 4827 - 4834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Chakrabarty Microorganisms and Cancer: Quest for a Therapy J. Bacteriol., May 1, 2003; 185(9): 2683 - 2686. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yamada, M. Goto, V. Punj, O. Zaborina, M. L. Chen, K. Kimbara, D. Majumdar, E. Cunningham, T. K. Das Gupta, and A. M. Chakrabarty Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer PNAS, October 29, 2002; 99(22): 14098 - 14103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ehlers, J. Benini, H.-D. Held, C. Roeck, G. Alber, and S. Uhlig {alpha}{beta} T Cell Receptor-positive Cells and Interferon-{gamma}, but not Inducible Nitric Oxide Synthase, Are Critical for Granuloma Necrosis in a Mouse Model of Mycobacteria-induced Pulmonary Immunopathology J. Exp. Med., December 17, 2001; 194(12): 1847 - 1859. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
