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The Journal of Immunology, 2001, 166: 5859-5863.
Copyright © 2001 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: FISP (IL-4-Induced Secreted Protein), a Novel Cytokine-Like Molecule Secreted by Th2 Cells1

Gabriele Schaefer, Chandrasekar Venkataraman2 and Ulrike Schindler

Tularik Inc., Two Corporate Drive, South San Francisco, CA 94080

Th cell subsets, namely Th1 and Th2 cells, play an important role in mounting an immune response against invading pathogens. Several genes are selectively up-regulated during differentiation and effector phases of Th subsets. In this study, we report the identification of a novel cytokine-like molecule designated FISP (IL-4-induced secreted protein), which is selectively expressed and secreted by Th2 cells. Detectable levels of FISP are observed only 3 days after initiation of Th2 differentiation. Expression of FISP in developing Th cells requires at least two signals: TCR signaling involving protein kinase C activation and STAT6-dependent IL-4R signaling.




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