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*OMIM
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Lupus
The Journal of Immunology, 2001, 166: 6-10.
Copyright © 2001 by The American Association of Immunologists


CUTTING EDGE

Cutting Edge: A Role for B Lymphocyte Stimulator in Systemic Lupus Erythematosus1

Jun Zhang*, Viktor Roschke*, Kevin P. Baker*, Zheng Wang{dagger}, Graciela S. Alarcón{dagger}, Barri J. Fessler{dagger}, Holly Bastian{dagger}, Robert P. Kimberly2,{dagger} and Tong Zhou2,{dagger}

* Human Genome Sciences, Rockville, MD 20850; and {dagger} Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL 35294

Increased levels of B lymphocyte stimulator (BLyS) are associated with systemic autoimmunity in animal models of spontaneous autoimmune disease, and transgenic animals expressing BLyS develop typical autoimmune disease. Here, we demonstrate significant elevations of BLyS in the patients with systemic lupus erythematosus (SLE). The BLyS isolated from the sera of SLE patients had the same m.w. as the natural soluble form and was able to stimulate B cell activation in vitro. Increased BLyS in SLE patients was partially associated with higher levels of anti-dsDNA Ab of the IgG, IgM, and IgA classes, but not associated with the disease activity. Our results suggest that BLyS may be a useful marker for early activation of an autoimmune diathesis and likely plays a critical role in triggering activation of self-Ag-driven autoimmune B cells in human SLE. BLyS may provide an effective therapeutic target in systemic autoimmunity.




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APRIL-Deficient Mice Have Normal Immune System Development
Mol. Cell. Biol., February 1, 2004; 24(3): 997 - 1006.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
M. Batten, C. Fletcher, L. G. Ng, J. Groom, J. Wheway, Y. Laabi, X. Xin, P. Schneider, J. Tschopp, C. R. Mackay, et al.
TNF Deficiency Fails to Protect BAFF Transgenic Mice against Autoimmunity and Reveals a Predisposition to B Cell Lymphoma
J. Immunol., January 15, 2004; 172(2): 812 - 822.
[Abstract] [Full Text] [PDF]


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BloodHome page
C. Kern, J.-F. Cornuel, C. Billard, R. Tang, D. Rouillard, V. Stenou, T. Defrance, F. Ajchenbaum-Cymbalista, P.-Y. Simonin, S. Feldblum, et al.
Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway
Blood, January 15, 2004; 103(2): 679 - 688.
[Abstract] [Full Text] [PDF]


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Int ImmunolHome page
K. Schneider, S. Kothlow, P. Schneider, A. Tardivel, T. Gobel, B. Kaspers, and P. Staeheli
Chicken BAFF--a highly conserved cytokine that mediates B cell survival
Int. Immunol., January 1, 2004; 16(1): 139 - 148.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
M. Pelletier, J. S. Thompson, F. Qian, S. A. Bixler, D. Gong, T. Cachero, K. Gilbride, E. Day, M. Zafari, C. Benjamin, et al.
Comparison of Soluble Decoy IgG Fusion Proteins of BAFF-R and BCMA as Antagonists for BAFF
J. Biol. Chem., August 29, 2003; 278(35): 33127 - 33133.
[Abstract] [Full Text] [PDF]


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Rheumatology (Oxford)Home page
T. Koyama, H. Tsukamoto, K. Masumoto, D. Himeji, K. Hayashi, M. Harada, and T. Horiuchi
A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus
Rheumatology, August 1, 2003; 42(8): 980 - 985.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
I. J. Amanna, J. P. Dingwall, and C. E. Hayes
Enforced bcl-xL Gene Expression Restored Splenic B Lymphocyte Development in BAFF-R Mutant Mice
J. Immunol., May 1, 2003; 170(9): 4593 - 4600.
[Abstract] [Full Text] [PDF]


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JEMHome page
P. Scapini, B. Nardelli, G. Nadali, F. Calzetti, G. Pizzolo, C. Montecucco, and M. A. Cassatella
G-CSF-stimulated Neutrophils Are a Prominent Source of Functional BLyS
J. Exp. Med., February 3, 2003; 197(3): 297 - 302.
[Abstract] [Full Text] [PDF]


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Ann Rheum DisHome page
X Mariette, S Roux, J Zhang, D Bengoufa, F Lavie, T Zhou, and R Kimberly
The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjogren's syndrome
Ann Rheum Dis, February 1, 2003; 62(2): 168 - 171.
[Abstract] [Full Text] [PDF]


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LupusHome page
L E Schiffer, N Hussain, X Wang, W Huang, J Sinha, M Ramanujam, and A Davidson
Lowering anti-dsDNA antibodies--what's new?
Lupus, December 1, 2002; 11(12): 885 - 894.
[Abstract] [PDF]


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J. Immunol.Home page
V. Roschke, S. Sosnovtseva, C. D. Ward, J. S. Hong, R. Smith, V. Albert, W. Stohl, K. P. Baker, S. Ullrich, B. Nardelli, et al.
BLyS and APRIL Form Biologically Active Heterotrimers That Are Expressed in Patients with Systemic Immune-Based Rheumatic Diseases
J. Immunol., October 15, 2002; 169(8): 4314 - 4321.
[Abstract] [Full Text] [PDF]


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LupusHome page
P Youinou, P M Lydyard, and R A Mageed
B cells underpin lupus immunopathology
Lupus, January 1, 2002; 11(1): 1 - 3.
[PDF]


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J. Immunol.Home page
T. Higuchi, Y. Aiba, T. Nomura, J. Matsuda, K. Mochida, M. Suzuki, H. Kikutani, T. Honjo, K. Nishioka, and T. Tsubata
Cutting Edge: Ectopic Expression of CD40 Ligand on B Cells Induces Lupus-Like Autoimmune Disease
J. Immunol., January 1, 2002; 168(1): 9 - 12.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
S. Xu and K.-P. Lam
B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses
Mol. Cell. Biol., June 15, 2001; 21(12): 4067 - 4074.
[Abstract] [Full Text]




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