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CUTTING EDGE |
*
Human Genome Sciences, Rockville, MD 20850; and
Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL 35294
Increased levels of B lymphocyte stimulator (BLyS) are associated with systemic autoimmunity in animal models of spontaneous autoimmune disease, and transgenic animals expressing BLyS develop typical autoimmune disease. Here, we demonstrate significant elevations of BLyS in the patients with systemic lupus erythematosus (SLE). The BLyS isolated from the sera of SLE patients had the same m.w. as the natural soluble form and was able to stimulate B cell activation in vitro. Increased BLyS in SLE patients was partially associated with higher levels of anti-dsDNA Ab of the IgG, IgM, and IgA classes, but not associated with the disease activity. Our results suggest that BLyS may be a useful marker for early activation of an autoimmune diathesis and likely plays a critical role in triggering activation of self-Ag-driven autoimmune B cells in human SLE. BLyS may provide an effective therapeutic target in systemic autoimmunity.
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 M. Pelletier, J. S. Thompson, F. Qian, S. A. Bixler, D. Gong, T. Cachero, K. Gilbride, E. Day, M. Zafari, C. Benjamin, et al. Comparison of Soluble Decoy IgG Fusion Proteins of BAFF-R and BCMA as Antagonists for BAFF J. Biol. Chem., August 29, 2003; 278(35): 33127 - 33133. [Abstract] [Full Text] [PDF]
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T. Koyama, H. Tsukamoto, K. Masumoto, D. Himeji, K. Hayashi, M. Harada, and T. Horiuchi A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus Rheumatology, August 1, 2003; 42(8): 980 - 985. [Abstract] [Full Text] [PDF]
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I. J. Amanna, J. P. Dingwall, and C. E. Hayes Enforced bcl-xL Gene Expression Restored Splenic B Lymphocyte Development in BAFF-R Mutant Mice J. Immunol., May 1, 2003; 170(9): 4593 - 4600. [Abstract] [Full Text] [PDF]
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P. Scapini, B. Nardelli, G. Nadali, F. Calzetti, G. Pizzolo, C. Montecucco, and M. A. Cassatella G-CSF-stimulated Neutrophils Are a Prominent Source of Functional BLyS J. Exp. Med., February 3, 2003; 197(3): 297 - 302. [Abstract] [Full Text] [PDF]
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X Mariette, S Roux, J Zhang, D Bengoufa, F Lavie, T Zhou, and R Kimberly The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjogren's syndrome Ann Rheum Dis, February 1, 2003; 62(2): 168 - 171. [Abstract] [Full Text] [PDF]
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L E Schiffer, N Hussain, X Wang, W Huang, J Sinha, M Ramanujam, and A Davidson Lowering anti-dsDNA antibodies--what's new? Lupus, December 1, 2002; 11(12): 885 - 894. [Abstract] [PDF]
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V. Roschke, S. Sosnovtseva, C. D. Ward, J. S. Hong, R. Smith, V. Albert, W. Stohl, K. P. Baker, S. Ullrich, B. Nardelli, et al. BLyS and APRIL Form Biologically Active Heterotrimers That Are Expressed in Patients with Systemic Immune-Based Rheumatic Diseases J. Immunol., October 15, 2002; 169(8): 4314 - 4321. [Abstract] [Full Text] [PDF]
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P Youinou, P M Lydyard, and R A Mageed B cells underpin lupus immunopathology Lupus, January 1, 2002; 11(1): 1 - 3. [PDF]
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T. Higuchi, Y. Aiba, T. Nomura, J. Matsuda, K. Mochida, M. Suzuki, H. Kikutani, T. Honjo, K. Nishioka, and T. Tsubata Cutting Edge: Ectopic Expression of CD40 Ligand on B Cells Induces Lupus-Like Autoimmune Disease J. Immunol., January 1, 2002; 168(1): 9 - 12. [Abstract] [Full Text] [PDF]
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S. Xu and K.-P. Lam B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses Mol. Cell. Biol., June 15, 2001; 21(12): 4067 - 4074. [Abstract] [Full Text]
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