| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814;
Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115;
Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; and
Division of Molecular Medicine, North Shore University Hospital, Manhasset, NY 11030
Overproduction of inflammatory mediators by macrophages in response
to Gram-negative LPS has been implicated in septic shock. Recent
reports indicate that three membrane-associated proteins, CD14,
CD11b/CD18, and Toll-like receptor (TLR) 4, may serve as LPS
recognition and/or signaling receptors in murine macrophages.
Therefore, the relative contribution of these proteins in the induction
of cyclooxygenase 2 (COX-2), IL-12 p35, IL-12 p40, TNF-
,
IFN-inducible protein (IP)-10, and IFN consensus sequence binding
protein (ICSBP) genes in response to LPS or the LPS-mimetic, Taxol, was
examined using macrophages derived from mice deficient for these
membrane-associated proteins. The panel of genes selected reflects
diverse macrophage effector functions that contribute to the
pathogenesis of septic shock. Induction of the entire panel of genes in
response to low concentrations of LPS or Taxol requires the
participation of both CD14 and TLR4, whereas high concentrations of LPS
or Taxol elicit the expression of a subset of LPS-inducible genes in
the absence of CD14. In contrast, for optimal induction of COX-2, IL-12
p35, and IL-12 p40 genes by low concentrations of LPS or by all
concentrations of Taxol, CD11b/CD18 was also required. Mitigated
induction of COX-2, IL-12 p35, and IL-12 p40 gene expression by
CD11b/CD18-deficient macrophages correlated with a marked inhibition of
NF-
B nuclear translocation and mitogen-activated protein kinase
(MAPK) activation in response to Taxol and of NF-B nuclear
translocation in response to LPS. These findings suggest that for
expression of a full repertoire of LPS-/Taxol-inducible genes, CD14,
TLR4, and CD11b/CD18 must be coordinately engaged to deliver optimal
signaling to the macrophage.
This article has been cited by other articles:
|
|
 |
|
  S. K. Bunt, V. K. Clements, E. M. Hanson, P. Sinha, and S. Ostrand-Rosenberg Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4 J. Leukoc. Biol., June 1, 2009; 85(6): 996 - 1004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Morrison, J. D. Simmons, and M. T. Heise Complement Receptor 3 Promotes Severe Ross River Virus-Induced Disease J. Virol., November 15, 2008; 82(22): 11263 - 11272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Hu, D. Zhang, H. Pang, W. M. Caudle, Y. Li, H. Gao, Y. Liu, L. Qian, B. Wilson, D. A. Di Monte, et al. Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease J. Immunol., November 15, 2008; 181(10): 7194 - 7204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Scott and T. R. Billiar {beta}2-Integrin-induced p38 MAPK Activation Is a Key Mediator in the CD14/TLR4/MD2-dependent Uptake of Lipopolysaccharide by Hepatocytes J. Biol. Chem., October 24, 2008; 283(43): 29433 - 29446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Whitaker, M. Colmenares, K. G. Pestana, and D. McMahon-Pratt Leishmania pifanoi Proteoglycolipid Complex P8 Induces Macrophage Cytokine Production through Toll-Like Receptor 4 Infect. Immun., May 1, 2008; 76(5): 2149 - 2156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Goebel, D. N. Wolfe, K. Elder, S. Stibitz, and E. T. Harvill O Antigen Protects Bordetella parapertussis from Complement Infect. Immun., April 1, 2008; 76(4): 1774 - 1780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Douin-Echinard, S. Laffont, C. Seillet, L. Delpy, A. Krust, P. Chambon, P. Gourdy, J.-F. Arnal, and J.-C. Guery Estrogen Receptor {alpha}, but Not {beta}, Is Required for Optimal Dendritic Cell Differentiation and CD40-Induced Cytokine Production J. Immunol., March 15, 2008; 180(6): 3661 - 3669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tsutsumi-Ishii, K. Shimada, H. Daida, R. Toman, and I. Nagaoka Low potency of Chlamydophila LPS to activate human mononuclear cells due to its reduced affinities for CD14 and LPS-binding protein Int. Immunol., February 1, 2008; 20(2): 199 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Lee, C. Moon, H. W. Lee, E.-M. Park, M.-S. Cho, and J. L. Kang Src Tyrosine Kinases Mediate Activations of NF-{kappa}B and Integrin Signal during Lipopolysaccharide-Induced Acute Lung Injury J. Immunol., November 15, 2007; 179(10): 7001 - 7011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-F. Wong, J. M. Luk, R. H. Cheng, L. B. Klickstein, and S.-T. Fan Characterization of two novel LPS-binding sites in leukocyte integrin {beta}A domain FASEB J, October 1, 2007; 21(12): 3231 - 3239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Figueiredo, P. L. Fernandez, D. S. Mourao-Sa, B. N. Porto, F. F. Dutra, L. S. Alves, M. F. Oliveira, P. L. Oliveira, A. V. Graca-Souza, and M. T. Bozza Characterization of Heme as Activator of Toll-like Receptor 4 J. Biol. Chem., July 13, 2007; 282(28): 20221 - 20229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Medvedev, W. Piao, J. Shoenfelt, S. H. Rhee, H. Chen, S. Basu, L. M. Wahl, M. J. Fenton, and S. N. Vogel Role of TLR4 Tyrosine Phosphorylation in Signal Transduction and Endotoxin Tolerance J. Biol. Chem., June 1, 2007; 282(22): 16042 - 16053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kuuliala, A. Orpana, M. Leirisalo-Repo, and H. Repo Neutrophils of healthy subjects with a history of reactive arthritis show enhanced responsiveness, as defined by CD11b expression in adherent and non-adherent whole blood cultures Rheumatology, June 1, 2007; 46(6): 934 - 937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Mayer, M. Muehmer, J. Mages, K. Gueinzius, C. Hess, K. Heeg, R. Bals, R. Lang, and A. H. Dalpke Differential Recognition of TLR-Dependent Microbial Ligands in Human Bronchial Epithelial Cells J. Immunol., March 1, 2007; 178(5): 3134 - 3142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Leon, N. Contractor, I. Fuss, T. Marth, E. Lahey, S. Iwaki, A. la Sala, V. Hoffmann, W. Strober, and B. L. Kelsall Antibodies to Complement Receptor 3 Treat Established Inflammation in Murine Models of Colitis and a Novel Model of Psoriasiform Dermatitis J. Immunol., November 15, 2006; 177(10): 6974 - 6982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Rallabhandi, J. Bell, M. S. Boukhvalova, A. Medvedev, E. Lorenz, M. Arditi, V. G. Hemming, J. C. G. Blanco, D. M. Segal, and S. N. Vogel Analysis of TLR4 Polymorphic Variants: New Insights into TLR4/MD-2/CD14 Stoichiometry, Structure, and Signaling J. Immunol., July 1, 2006; 177(1): 322 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Behera, E. Hildebrand, S. Uematsu, S. Akira, J. Coburn, and L. T. Hu Identification of a TLR-Independent Pathway for Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases and Inflammatory Mediators through Binding to Integrin {alpha}3beta1 J. Immunol., July 1, 2006; 177(1): 657 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Medvedev, I. Sabroe, J. D. Hasday, and S. N. Vogel Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease Innate Immunity, June 1, 2006; 12(3): 133 - 150. [Abstract] [PDF]
|
|
|
|
|
|
S. Totemeyer, M. Sheppard, A. Lloyd, D. Roper, C. Dowson, D. Underhill, P. Murray, D. Maskell, and C. Bryant IFN-{gamma} Enhances Production of Nitric Oxide from Macrophages via a Mechanism That Depends on Nucleotide Oligomerization Domain-2. J. Immunol., April 15, 2006; 176(8): 4804 - 4810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Lei, X. Tan, N. Qureshi, and D. C. Morrison Regulation of Cellular Caveolin-1 Protein Expression in Murine Macrophages by Microbial Products Infect. Immun., December 1, 2005; 73(12): 8136 - 8143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Vogel, A. A. Awomoyi, P. Rallabhandi, and A. E. Medvedev Mutations in TLR4 signaling that lead to increased susceptibility to infection in humans: an overview Innate Immunity, December 1, 2005; 11(6): 333 - 339. [Abstract] [PDF]
|
|
|
|
|
|
G. Hajishengallis, P. Ratti, and E. Harokopakis Peptide Mapping of Bacterial Fimbrial Epitopes Interacting with Pattern Recognition Receptors J. Biol. Chem., November 25, 2005; 280(47): 38902 - 38913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Svensson, S. Zubairi, A. Maroof, F. Kazi, M. Taniguchi, and P. M. Kaye Invariant NKT Cells Are Essential for the Regulation of Hepatic CXCL10 Gene Expression during Leishmania donovani Infection Infect. Immun., November 1, 2005; 73(11): 7541 - 7547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hattar, S. van Burck, A. Bickenbach, U. Grandel, U. Maus, J. Lohmeyer, E. Csernok, T. Hartung, W. Seeger, F. Grimminger, et al. Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation J. Leukoc. Biol., October 1, 2005; 78(4): 992 - 1000. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Perlik, Z. Li, S. Goorha, L. R. Ballou, and C. M. Blatteis LPS-activated complement, not LPS per se, triggers the early release of PGE2 by Kupffer cells Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R332 - R339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Steiner, S. Chakravarty, J. R. Robbins, A. S. Dragic, J. Pan, M. Herkenham, and A. A. Romanovsky Thermoregulatory responses of rats to conventional preparations of lipopolysaccharide are caused by lipopolysaccharide per se-- not by lipoprotein contaminants Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R348 - R352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Parker, M. K. B. Whyte, S. K. Dower, and I. Sabroe The expression and roles of Toll-like receptors in the biology of the human neutrophil J. Leukoc. Biol., June 1, 2005; 77(6): 886 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Hedges, K. J. Lubick, and M. A. Jutila {gamma}{delta} T Cells Respond Directly to Pathogen-Associated Molecular Patterns J. Immunol., May 15, 2005; 174(10): 6045 - 6053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lentschat, H. Karahashi, K. S. Michelsen, L. S. Thomas, W. Zhang, S. N. Vogel, and M. Arditi Mastoparan, a G Protein Agonist Peptide, Differentially Modulates TLR4- and TLR2-Mediated Signaling in Human Endothelial Cells and Murine Macrophages J. Immunol., April 1, 2005; 174(7): 4252 - 4261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Richardson, M. G. Ottolini, L. Pletneva, M. Boukhvalova, S. Zhang, S. N. Vogel, G. A. Prince, and J. C. G. Blanco Respiratory Syncytial Virus (RSV) Infection Induces Cyclooxygenase 2: A Potential Target for RSV Therapy J. Immunol., April 1, 2005; 174(7): 4356 - 4364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhou, X.-P. Gao, J. Fan, Q. Liu, K. N. Anwar, R. S. Frey, and A. B. Malik LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L655 - L662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jeyaseelan, H. W. Chu, S. K. Young, M. W. Freeman, and G. S. Worthen Distinct Roles of Pattern Recognition Receptors CD14 and Toll-Like Receptor 4 in Acute Lung Injury Infect. Immun., March 1, 2005; 73(3): 1754 - 1763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Tobias and L. K. Curtiss Thematic review series: The Immune System and Atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesis J. Lipid Res., March 1, 2005; 46(3): 404 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Heinzelmann and H. Bosshart Heparin Binds to Lipopolysaccharide (LPS)-Binding Protein, Facilitates the Transfer of LPS to CD14, and Enhances LPS-Induced Activation of Peripheral Blood Monocytes J. Immunol., February 15, 2005; 174(4): 2280 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Bjorkbacka, K. A. Fitzgerald, F. Huet, X. Li, J. A. Gregory, M. A. Lee, C. M. Ordija, N. E. Dowley, D. T. Golenbock, and M. W. Freeman The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades Physiol Genomics, February 7, 2005; 19(3): 319 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Sacre, E. Andreakos, M. Feldmann, and B. M. Foxwell Endotoxin signaling in human macrophages: signaling via an alternate mechanism Innate Immunity, December 1, 2004; 10(6): 445 - 452. [Abstract] [PDF]
|
|
|
|
 |
|
 A. L. Feire, H. Koss, and T. Compton Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain PNAS, October 26, 2004; 101(43): 15470 - 15475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Whitsett, C. J. Bachurski, K. C. Barnes, P. A. Bunn Jr., L. M. Case, D. N. Cook, D. Crooks, M. W. Duncan, L. Dwyer-Nield, R. C. Elston, et al. Functional Genomics of Lung Disease Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2/S1): S1 - S81. [Full Text] [PDF]
|
|
|
|
|
|
D. E. Spaner Amplifying cancer vaccine responses by modifying pathogenic gene programs in tumor cells J. Leukoc. Biol., August 1, 2004; 76(2): 338 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Romanovsky Anorexia: the toll for lipopolysaccharide recognition Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R274 - R275. [Full Text] [PDF]
|
|
|
|
|
|
S. Noubir, Z. Hmama, and N. E. Reiner Dual Receptors and Distinct Pathways Mediate Interleukin-1 Receptor-associated Kinase Degradation in Response to Lipopolysaccharide: INVOLVEMENT OF CD14/TLR4, CR3, AND PHOSPHATIDYLINOSITOL 3-KINASE J. Biol. Chem., June 11, 2004; 279(24): 25189 - 25195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Iontcheva, S. Amar, K. H. Zawawi, A. Kantarci, and T. E. Van Dyke Role for Moesin in Lipopolysaccharide-Stimulated Signal Transduction Infect. Immun., April 1, 2004; 72(4): 2312 - 2320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Morrison, C. B. Wilson, M. Ray, and P. H. Correll Macrophage-Stimulating Protein, the Ligand for the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase, Inhibits IL-12 Production by Primary Peritoneal Macrophages Stimulated with IFN-{gamma} and Lipopolysaccharide J. Immunol., February 1, 2004; 172(3): 1825 - 1832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Campos, G. M. S. Rosinha, I. C. Almeida, X. S. Salgueiro, B. W. Jarvis, G. A. Splitter, N. Qureshi, O. Bruna-Romero, R. T. Gazzinelli, and S. C. Oliveira Role of Toll-Like Receptor 4 in Induction of Cell-Mediated Immunity and Resistance to Brucella abortus Infection in Mice Infect. Immun., January 1, 2004; 72(1): 176 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Gioannini, A. Teghanemt, K. A. Zarember, and J. P. Weiss Regulation of interactions of endotoxin with host cells Innate Immunity, December 1, 2003; 9(6): 401 - 408. [Abstract] [PDF]
|
|
|
|
 |
|
 S. N. Vogel, K. A. Fitzgerald, and M. J. Fenton TLRs: Differential Adapter Utilization by Toll-Like Receptors Mediates TLR-Specific Patterns of Gene Expression Mol. Interv., December 1, 2003; 3(8): 466 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Levy, R. M. Jean-Jacques, C. Cywes, R. B. Sisson, K. A. Zarember, P. J. Godowski, J. L. Christianson, H.-K. Guttormsen, M. C. Carroll, A. Nicholson-Weller, et al. Critical Role of the Complement System in Group B Streptococcus-Induced Tumor Necrosis Factor Alpha Release Infect. Immun., November 1, 2003; 71(11): 6344 - 6353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Sabroe, R. C. Read, M. K. B. Whyte, D. H. Dockrell, S. N. Vogel, and S. K. Dower Toll-Like Receptors in Health and Disease: Complex Questions Remain J. Immunol., August 15, 2003; 171(4): 1630 - 1635. [Full Text] [PDF]
|
|
|
|
|
|
N. Qureshi, P.-Y. Perera, J. Shen, G. Zhang, A. Lenschat, G. Splitter, D. C. Morrison, and S. N. Vogel The Proteasome as a Lipopolysaccharide-Binding Protein in Macrophages: Differential Effects of Proteasome Inhibition on Lipopolysaccharide-Induced Signaling Events J. Immunol., August 1, 2003; 171(3): 1515 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Augusto, M. Synguelakis, Q. Espinassous, M. Lepoivre, J. Johansson, and R. Chaby Cellular Antiendotoxin Activities of Lung Surfactant Protein C in Lipid Vesicles Am. J. Respir. Crit. Care Med., August 1, 2003; 168(3): 335 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rodriguez, A. C. Keller, E. L. Faquim-Mauro, M. S. de Macedo, F. Q. Cunha, J. Lefort, B. B. Vargaftig, and M. Russo Bacterial Lipopolysaccharide Signaling Through Toll-Like Receptor 4 Suppresses Asthma-Like Responses Via Nitric Oxide Synthase 2 Activity J. Immunol., July 15, 2003; 171(2): 1001 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Van Amersfoort, T. J. C. Van Berkel, and J. Kuiper Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock Clin. Microbiol. Rev., July 1, 2003; 16(3): 379 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tamai, S. Sugawara, O. Takeuchi, S. Akira, and H. Takada Synergistic effects of lipopolysaccharide and interferon-{gamma} in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, Toll-like receptor 4, MD-2 and MyD88 expression Innate Immunity, June 1, 2003; 9(3): 145 - 153. [Abstract] [PDF]
|
|
|
|
|
|
R. Silverstein and D. C. Johnson Endogenous versus exogenous glucocorticoid responses to experimental bacterial sepsis J. Leukoc. Biol., April 1, 2003; 73(4): 417 - 427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dunne and L. A. J. O'Neill The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense Sci. Signal., February 25, 2003; 2003(171): re3 - re3. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Wang, B. J. Manning, Q. D. Wu, S. Blankson, D. Bouchier-Hayes, and H. P. Redmond Endotoxin/Lipopolysaccharide Activates NF-{kappa}B and Enhances Tumor Cell Adhesion and Invasion Through a {beta}1 Integrin-Dependent Mechanism J. Immunol., January 15, 2003; 170(2): 795 - 804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-F. Petit-Bertron, C. Fitting, J.-M. Cavaillon, and M. Adib-Conquy Adherence influences monocyte responsiveness to interleukin-10 J. Leukoc. Biol., January 1, 2003; 73(1): 145 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bosshart and M. Heinzelmann Arginine-Rich Cationic Polypeptides Amplify Lipopolysaccharide-Induced Monocyte Activation Infect. Immun., December 1, 2002; 70(12): 6904 - 6910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Pacheco, F. A. Bozza, R. N. Gomes, M. Bozza, P. F. Weller, H. C. Castro-Faria-Neto, and P. T. Bozza Lipopolysaccharide-Induced Leukocyte Lipid Body Formation In Vivo: Innate Immunity Elicited Intracellular Loci Involved in Eicosanoid Metabolism J. Immunol., December 1, 2002; 169(11): 6498 - 6506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Schilling, K. Thomas, K. Nixdorff, S. N. Vogel, and M. J. Fenton Toll-Like Receptor 4 and Toll-IL-1 Receptor Domain-Containing Adapter Protein (TIRAP)/Myeloid Differentiation Protein 88 Adapter-Like (Mal) Contribute to Maximal IL-6 Expression in Macrophages J. Immunol., November 15, 2002; 169(10): 5874 - 5880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Knuefermann, S. Nemoto, A. Misra, N. Nozaki, G. Defreitas, S. M. Goyert, B. A. Carabello, D. L. Mann, and J. G. Vallejo CD14-Deficient Mice Are Protected Against Lipopolysaccharide-Induced Cardiac Inflammation and Left Ventricular Dysfunction Circulation, November 12, 2002; 106(20): 2608 - 2615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Shuling Zhang, K. Thomas, J. C.G. Blanco, C. A. Salkowski, and S. N. Vogel The role of the interferon regulatory factors, IRF-1 and IRF-2, in LPS-induced cyclooxygenase-2 (COX-2) expression in vivo and in vitro Innate Immunity, October 1, 2002; 8(5): 381 - 390. [Abstract] [PDF]
|
|
|
|
|
|
P. Henneke, O. Takeuchi, R. Malley, E. Lien, R. R. Ingalls, M. W. Freeman, T. Mayadas, V. Nizet, S. Akira, D. L. Kasper, et al. Cellular Activation, Phagocytosis, and Bactericidal Activity Against Group B Streptococcus Involve Parallel Myeloid Differentiation Factor 88-Dependent and Independent Signaling Pathways J. Immunol., October 1, 2002; 169(7): 3970 - 3977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Applequist, R. P. A. Wallin, and H.-G. Ljunggren Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines Int. Immunol., September 1, 2002; 14(9): 1065 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Monick, L. Powers, N. Butler, T. Yarovinsky, and G. W. Hunninghake Interaction of matrix with integrin receptors is required for optimal LPS-induced MAP kinase activation Am J Physiol Lung Cell Mol Physiol, August 1, 2002; 283(2): L390 - L402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.M. Monick and G.W. Hunninghake Activation of second messenger pathways in alveolar macrophages by endotoxin Eur. Respir. J., July 1, 2002; 20(1): 210 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M A Moscarello, B Mak, T A Nguyen, D D Wood, F Mastronardi, and S K Ludwin Paclitaxel (Taxol) attenuates clinical disease in a spontaneously demyelinating transgenic mouse and induces remyelination Multiple Sclerosis, April 1, 2002; 8(2): 130 - 138. [Abstract] [PDF]
|
|
|
|
 |
|
 G. Hajishengallis, M. Martin, H. T. Sojar, A. Sharma, R. E. Schifferle, E. DeNardin, M. W. Russell, and R. J. Genco Dependence of Bacterial Protein Adhesins on Toll-Like Receptors for Proinflammatory Cytokine Induction Clin. Vaccine Immunol., March 1, 2002; 9(2): 403 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. B. Cassidy, P. J. Moos, R. C. Kelly, and F. A. Fitzpatrick Cyclooxygenase-2 Induction by Paclitaxel, Docetaxel, and Taxane Analogues in Human Monocytes and Murine Macrophages: Structure-Activity Relationships and Their Implications Clin. Cancer Res., March 1, 2002; 8(3): 846 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kawai, O. Takeuchi, T. Fujita, J.-i. Inoue, P. F. Muhlradt, S. Sato, K. Hoshino, and S. Akira Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes J. Immunol., November 15, 2001; 167(10): 5887 - 5894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Monick, R. K. Mallampalli, A. B. Carter, D. M. Flaherty, D. McCoy, P. K. Robeff, M. W. Peterson, and G. W. Hunninghake Ceramide Regulates Lipopolysaccharide-Induced Phosphatidylinositol 3-Kinase and Akt Activity in Human Alveolar Macrophages J. Immunol., November 15, 2001; 167(10): 5977 - 5985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. I. Song, T. A. Abraham, Y. Park, A. S. Zivony, B. Harten, H. F. Edelhauser, S. L. Ward, C. A. Armstrong, and J. C. Ansel The Expression of Functional LPS Receptor Proteins CD14 And Toll-Like Receptor 4 in Human Corneal Cells Invest. Ophthalmol. Vis. Sci., November 1, 2001; 42(12): 2867 - 2877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Diks, S. J.H. van Deventer, and M. P. Peppelenbosch Invited review: Lipopolysaccharide recognition, internalisation, signalling and other cellular effects Innate Immunity, October 1, 2001; 7(5): 335 - 348. [Abstract] [PDF]
|
|
|
|
 |
|
 M. G. Schwacha, C. P. Schneider, K. I. Bland, and I. H. Chaudry Resistance of macrophages to the suppressive effect of interleukin-10 following thermal injury Am J Physiol Cell Physiol, October 1, 2001; 281(4): C1180 - C1187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Smiley, J. A. King, and W. W. Hancock Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4 J. Immunol., September 1, 2001; 167(5): 2887 - 2894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pedron, R. Girard, and R. Chaby Down-Modulation of L-Selectin by Lipopolysaccharide Is Not Required for Lipopolysaccharide-Induced Expression of CD14 in Mouse Bone Marrow Granulocytes Infect. Immun., July 1, 2001; 69(7): 4287 - 4294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kougias, D. Wei, P. J. Rice, H. E. Ensley, J. Kalbfleisch, D. L. Williams, and I. W. Browder Normal Human Fibroblasts Express Pattern Recognition Receptors for Fungal (1{right-arrow}3)-{beta}-D-Glucans Infect. Immun., June 1, 2001; 69(6): 3933 - 3938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Alexander and E. Th. Rietschel Invited review: Bacterial lipopolysaccharides and innate immunity Innate Immunity, June 1, 2001; 7(3): 167 - 202. [Abstract] [PDF]
|
|
|
|
|
|
S. Vogel, M. J. Hirschfeld, and P.-Y. Perera Signal integration in lipopolysaccharide (LPS)-stimulated murine macrophages Innate Immunity, June 1, 2001; 7(3): 237 - 241. [Abstract] [PDF]
|
|
|
|
|
|
J. E.-L. Tan, S.-C. Wong, S. K.-E. Gan, S. Xu, and K.-P. Lam The Adaptor Protein BLNK Is Required for B Cell Antigen Receptor-induced Activation of Nuclear Factor-kappa B and Cell Cycle Entry and Survival of B Lymphocytes J. Biol. Chem., June 1, 2001; 276(23): 20055 - 20063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sanlioglu, C. M. Williams, L. Samavati, N. S. Butler, G. Wang, P. B. McCray Jr., T. C. Ritchie, G. W. Hunninghake, E. Zandi, and J. F. Engelhardt Lipopolysaccharide Induces Rac1-dependent Reactive Oxygen Species Formation and Coordinates Tumor Necrosis Factor-alpha Secretion through IKK Regulation of NF-kappa B J. Biol. Chem., August 3, 2001; 276(32): 30188 - 30198. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
