| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Otorhinolaryngology, Fukui Medical University, Fukui, Japan; and
Department of Biochemistry, Kobe University School of Medicine, Kobe, Japan
Fibroblasts, a rich source of chemokines, interact with eosinophils and play a key role in the pathogenesis of airway disease. RANTES is produced by fibroblasts to attract and activate eosinophils. LPS is known to induce RANTES and cause protein tyrosine phosphorylation. Nonreceptor protein tyrosine kinase Syk is widely expressed and an important role in intracellular signal transduction in hemopoietic cells. In the present study, we examined whether Syk was expressed in a number of primary human nasal polyp tissue-derived fibroblast lines and whether it played some role in cellular function. Syk proteins were expressed in human nasal fibroblasts, but the expression level varied. There were positive correlations between the level of Syk expression and RANTES production induced by LPS. Overexpression of wild-type Syk by gene transfer enhanced RANTES production from nasal fibroblasts stimulated with LPS. The decrease of Syk expression by the administration of Syk antisense inhibited RANTES production. These results suggest that Syk expression affects RANTES production in fibroblasts of nasal polyps.
This article has been cited by other articles:
|
|
 |
|
  S. Inubushi, M. Nagano-Fujii, K. Kitayama, M. Tanaka, C. An, H. Yokozaki, H. Yamamura, H. Nuriya, M. Kohara, K. Sada, et al. Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein tyrosine kinase Syk J. Gen. Virol., May 1, 2008; 89(5): 1231 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Luangdilok, C. Box, L. Patterson, W. Court, K. Harrington, L. Pitkin, P. Rhys-Evans, P. O-charoenrat, and S. Eccles Syk Tyrosine Kinase Is Linked to Cell Motility and Progression in Squamous Cell Carcinomas of the Head and Neck Cancer Res., August 15, 2007; 67(16): 7907 - 7916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ulanova, S. Asfaha, G. Stenton, A. Lint, D. Gilbertson, A. Schreiber, and D. Befus Involvement of Syk protein tyrosine kinase in LPS-induced responses in macrophages Innate Immunity, April 1, 2007; 13(2): 117 - 125. [Abstract] [PDF]
|
|
|
|
 |
|
 U. A. Desai, J. Pallos, A. A. K. Ma, B. R. Stockwell, L. M. Thompson, J. L. Marsh, and M. I. Diamond Biologically active molecules that reduce polyglutamine aggregation and toxicity Hum. Mol. Genet., July 1, 2006; 15(13): 2114 - 2124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ulanova, L. Puttagunta, M. Marcet-Palacios, M. Duszyk, U. Steinhoff, F. Duta, M.-K. Kim, Z. K. Indik, A. D. Schreiber, and A. D. Befus Syk tyrosine kinase participates in {beta}1-integrin signaling and inflammatory responses in airway epithelial cells Am J Physiol Lung Cell Mol Physiol, March 1, 2005; 288(3): L497 - L507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yamada, D. Zhu, A. Saxon, and K. Zhang CD45 Controls Interleukin-4-mediated IgE Class Switch Recombination in Human B Cells through Its Function as a Janus Kinase Phosphatase J. Biol. Chem., August 2, 2002; 277(32): 28830 - 28835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Stenton, M. Ulanova, R. E. Dery, S. Merani, M.-K. Kim, M. Gilchrist, L. Puttagunta, S. Musat-Marcu, D. James, A. D. Schreiber, et al. Inhibition of Allergic Inflammation in the Airways Using Aerosolized Antisense to Syk Kinase J. Immunol., July 15, 2002; 169(2): 1028 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Obergfell, K. Eto, A. Mocsai, C. Buensuceso, S. L. Moores, J. S. Brugge, C. A. Lowell, and S. J. Shattil Coordinate interactions of Csk, Src, and Syk kinases with {alpha}IIb{beta}3 initiate integrin signaling to the cytoskeleton J. Cell Biol., April 15, 2002; 157(2): 265 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yanagi, R. Inatome, J. Ding, H. Kitaguchi, V. L. J. Tybulewicz, and H. Yamamura Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice Blood, November 1, 2001; 98(9): 2869 - 2871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamada, S. Fujieda, S. Yanagi, H. Yamamura, R. Inatome, H. Yamamoto, H. Igawa, and H. Saito IL-1 Induced Chemokine Production Through the Association of Syk with TNF Receptor-Associated Factor-6 in Nasal Fibroblast Lines J. Immunol., July 1, 2001; 167(1): 283 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Obergfell, K. Eto, A. Mocsai, C. Buensuceso, S. L. Moores, J. S. Brugge, C. A. Lowell, and S. J. Shattil Coordinate interactions of Csk, Src, and Syk kinases with {alpha}IIb{beta}3 initiate integrin signaling to the cytoskeleton J. Cell Biol., April 15, 2002; 157(2): 265 - 275. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
