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Receptors on Human Monocytes by Th1 and Th2 Cytokines1
*
Department of Medicine, Hospital for Special Surgery and Weill Medical College of Cornell University, New York, NY 10021;
Laboratoire d’Immunologie Cellulaire et Clinique, Institut National de la Santé et de la Recherche Médicale Unité 255, Institut Curie, Paris, France; and
Fakultät für Chemie, Universität Bielefeld, Bielefeld, Germany
Immune complex-mediated inflammatory responses are initiated by
Fc
R on phagocytes. We report in this study that an inhibitory
receptor, FcRIIb2, is expressed on circulating human monocytes, and
when co-cross-linked with stimulatory FcR it down-regulates effector
function. FcRIIb2 expression is increased by IL-4 and decreased by
IFN-, in contrast to the activating receptor, FcRIIa, which is
increased by IFN- and decreased by IL-4. Thus, Th1 and Th2 cytokines
differentially regulate the opposing FcR systems, altering the
balance of activating and inhibiting FcR. The detection and cytokine
modulation of FcRIIb2 in human myeloid cells provide evidence of a
negative regulator of immune complex-mediated responses in human
phagocytes and offer a new approach to limit Ab-triggered inflammation
in autoimmune disease.
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