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-Chain Cytoplasmic Tail1
Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101
IL-7/IL-7R signaling functions in both growth and differentiation
during T cell development. In this study, we examined the extent these
activities were controlled by signaling associated with distinct
IL-7R
cytoplasmic domains by transgenic expression of wild-type or
cytoplasmic deletion mutants of IL-7R in the thymi of
IL-7R-/- mice. We show an essential requirement for
the tyrosine-containing carboxyl-terminal T domain in restoring thymic
cellularity, pro-/pre-T cell progression, and survival. In contrast,
the functional differentiation of TCR 
cells and the development
of TCR 
cells are partially independent of the T domain. Thus,
separate cytoplasmic domains of the IL-7R chain differentially
control distinct functions during T cell development, whereas normal
IL-7R-dependent thymic development requires the integrated activity of
all these domains.
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