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The Journal of Immunology, 2001, 166: 256-261.
Copyright © 2001 by The American Association of Immunologists

Absence of CD43 Fails to Alter T Cell Development and Responsiveness1

Douglas A. Carlow*, Stéphane Y. Corbel* and Hermann J. Ziltener2,*,{dagger}

* The Biomedical Research Centre and {dagger} Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Genetic elimination of CD43 has been associated with increased T cell adhesiveness and T cell hyperresponsiveness to mitogens and alloantigens. Therefore, we investigated whether T cell development was perturbed in CD43-deficient mice by breeding CD43null mice with male Ag (Hy)-specific TCR-transgenic mice. Neither positive nor negative thymic selection of male Ag-specific T cells were affected by CD43 status. Furthermore, we did not observe a substantial or consistent hyperresponsive pattern in HY-CD43null lymph node cells compared with littermate HY-CD43+/- lymph node cells upon analysis of in vitro T cell stimulation with male Ag or mitogen. These observations challenged original conclusions associating absence of CD43 with T cell hyperresponsiveness and led us to re-examine this association. Reported phenotypes of CD43null mice have been based on mice with a mixed 129xC57BL/6 genetic background. To exclude a possible influence of genetic background differences among individual mice we analyzed CD43null littermates that had been back-bred onto the C57BL/6 background for seven to eight generations. We found that CD43+ and CD43null littermates with the C57BL/6 background exhibited no differences in response to mitogen or alloantigen, thereby establishing that T cell hyperresponsiveness is not a general correlate of CD43 absence.




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