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RIII by CD3
in Murine NK Cells1
Department of Molecular Genetics, Chiba University Graduate School of Medicine, Chiba, Japan
Fc
RIII is involved in Ab-dependent cell-mediated cytotoxicity
(ADCC) and cytokine production by NK cells. Signaling and expression of
FcRIII are dependent on FcR. Although NK cells express not only
FcR but also CD3
, the role of CD3 in NK cell function remains
unclear. Here, we found that the expression of FcRIII on NK cells
from CD3-deficient mice is unexpectedly up-regulated compared with
that on cells from normal mice. Furthermore, ADCC and IFN-
production upon FcRIII-cross-linking by NK cells from
CD3-deficient mice were also up-regulated. Up-regulation of the
surface expression of FcRIII on CD3-deficient NK cells is not
mediated by transcriptional augmentation of either FcRIII or FcR
gene because there was no significant difference in the expression of
mRNA for FcRIII and FcR. Transfection of CD3 into a cell line
expressing FcRIII and FcR induced a decrease in the cell surface
expression of FcRIII. These findings reveal a negative regulatory
role of CD3 in FcRIII-mediated function of murine NK
cells.
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