| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Division of Oncology, Department of Medicine, and
Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305
We demonstrated previously that CD81-/- mice have an impaired Th2 response. To determine whether this impairment affected allergen-induced airway hyperreactivity (AHR), CD81-/- BALB/c mice and CD81+/+ littermates were sensitized i.p. and challenged intranasally with OVA. Although wild type developed severe AHR, CD81-/- mice showed normal airway reactivity and reduced airway inflammation. Nevertheless, OVA-specific T cell proliferation was similar in both groups of mice. Analysis of cytokines secreted by the responding CD81-/- T cells, particularly those derived from peribronchial draining lymph nodes, revealed a dramatic reduction in IL-4, IL-5, and IL-13 synthesis. The decrease in cytokine production was not due to an intrinsic T cell deficiency because naive CD81-/- T cells responded to polyclonal Th1 and Th2 stimulation with normal proliferation and cytokine production. Moreover, there was an increase in T cells and a decrease in B cells in peribronchial lymph nodes and in spleens of immunized CD81-/- mice compared with wild-type animals. Interestingly, OVA-specific Ig levels, including IgE, were similar in CD81-/- and CD81+/+ mice. Thus, CD81 plays a role in the development of AHR not by influencing Ag-specific IgE production but by regulating local cytokine production.
This article has been cited by other articles:
|
|
 |
|
  O. V. Kovalenko, X. H. Yang, and M. E. Hemler A Novel Cysteine Cross-linking Method Reveals a Direct Association between Claudin-1 and Tetraspanin CD9 Mol. Cell. Proteomics, November 1, 2007; 6(11): 1855 - 1867. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Stein, P. Primakoff, and D. Myles Sperm-egg fusion: events at the plasma membrane J. Cell Sci., December 15, 2004; 117(26): 6269 - 6274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Clark, A. Oelke, M. E. Johnson, K. D. Eilert, P. C. Simpson, and S. C. Todd CD81 Associates with 14-3-3 in a Redox-regulated Palmitoylation-dependent Manner J. Biol. Chem., May 7, 2004; 279(19): 19401 - 19406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cherukuri, T. Shoham, H. W. Sohn, S. Levy, S. Brooks, R. Carter, and S. K. Pierce The Tetraspanin CD81 Is Necessary for Partitioning of Coligated CD19/CD21-B Cell Antigen Receptor Complexes into Signaling-Active Lipid Rafts J. Immunol., January 1, 2004; 172(1): 370 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Feigelson, V. Grabovsky, R. Shamri, S. Levy, and R. Alon The CD81 Tetraspanin Facilitates Instantaneous Leukocyte VLA-4 Adhesion Strengthening to Vascular Cell Adhesion Molecule 1 (VCAM-1) under Shear Flow J. Biol. Chem., December 19, 2003; 278(51): 51203 - 51212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shoham, R. Rajapaksa, C. Boucheix, E. Rubinstein, J. C. Poe, T. F. Tedder, and S. Levy The Tetraspanin CD81 Regulates the Expression of CD19 During B Cell Development in a Postendoplasmic Reticulum Compartment J. Immunol., October 15, 2003; 171(8): 4062 - 4072. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Takeda, I. Tachibana, K. Miyado, M. Kobayashi, T. Miyazaki, T. Funakoshi, H. Kimura, H. Yamane, Y. Saito, H. Goto, et al. Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes J. Cell Biol., June 9, 2003; 161(5): 945 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Deng, R. H. Dekruyff, G. J. Freeman, D. T. Umetsu, and S. Levy Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses Int. Immunol., May 1, 2002; 14(5): 513 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Clark, Z. Zeng, A. L. Langford, S. M. Bowen, and S. C. Todd PGRL Is a Major CD81-Associated Protein on Lymphocytes and Distinguishes a New Family of Cell Surface Proteins J. Immunol., November 1, 2001; 167(9): 5115 - 5121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Takahashi, D. Bigler, Y. Ito, and J. M. White Sequence-Specific Interaction between the Disintegrin Domain of Mouse ADAM 3 and Murine Eggs: Role of {beta}1 Integrin-associated Proteins CD9, CD81, and CD98 Mol. Biol. Cell, April 1, 2001; 12(4): 809 - 820. [Abstract] [Full Text]
|
|
|
|
|
|
M. E. Hemler Specific tetraspanin functions J. Cell Biol., December 24, 2001; 155(7): 1103 - 1108. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
