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Immunobiology Laboratory, Imperial Cancer Research Fund, London, United Kingdom
B cells and dendritic cells (DC) internalize and degrade exogenous
Ags and present them as peptides bound to MHC class II molecules for
scrutiny by CD4+ T cells. Here we use an Ab specific for a
processed form of the model Ag, hen egg lysozyme (HEL), to demonstrate
that this protein is not efficiently presented by lymph node DC
following s.c. immunization. HEL presentation by the DC can be
dramatically enhanced upon coinjection of a microbial adjuvant, which
appears to act by enhancing peptide loading onto MHC class II. CD40
cross-linking or the presence of a high frequency of T cells specific
for HEL can similarly improve presentation by DC in vivo. For any of
these activating stimuli, CD8
+ DC consistently display
the highest proportion of HEL-loaded MHC class II molecules. These data
indicate that exogenous Ags can be displayed to T cells in lymphoid
tissues by a large cohort of resident DC whose presentation is
regulated by innate and adaptive stimuli. Our data further reveal the
existence of a feedback mechanism that augments Ag presentation during
cognate APC-T cell interactions.
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