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*
Basel Institute for Immunology, Basel, Switzerland; and
Electron Microscopy Unit, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Dendritic cells (DCs) exhibit considerable heterogeneity in their anatomical location, surface phenotype, and functional properties. In this study, we demonstrate that peripheral lymph nodes contain at least four major, functionally separable, and independently derived, DC subsets, which can be clearly demarcated by their CD11c, CD40, and CD8 expression pattern. Surprisingly, all DCs derived directly from the bone marrow, the myeloid- and the lymphoid-related subsets, turned over fast with t1/2 of a couple of days. In contrast, DCs exported from the skin, both dermal and epidermal, accumulated 3- to 4-fold slower, turnover that is dramatically increased by cutaneous inflammation.
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M. Menges, S. Ro{beta}ner, C. Voigtlander, H. Schindler, N. A. Kukutsch, C. Bogdan, K. Erb, G. Schuler, and M. B. Lutz Repetitive Injections of Dendritic Cells Matured with Tumor Necrosis Factor {alpha} Induce Antigen-specific Protection of Mice from Autoimmunity J. Exp. Med., December 31, 2001; 195(1): 15 - 22. [Abstract] [Full Text] [PDF]
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S. Henri, D. Vremec, A. Kamath, J. Waithman, S. Williams, C. Benoist, K. Burnham, S. Saeland, E. Handman, and K. Shortman The Dendritic Cell Populations of Mouse Lymph Nodes J. Immunol., July 15, 2001; 167(2): 741 - 748. [Abstract] [Full Text] [PDF]
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C. Ruedl, P. Koebel, and K. Karjalainen In Vivo-Matured Langerhans Cells Continue to Take Up and Process Native Proteins Unlike In Vitro-Matured Counterparts J. Immunol., June 15, 2001; 166(12): 7178 - 7182. [Abstract] [Full Text] [PDF]
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