The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kumar, H.
Right arrow Articles by Bockenstedt, L. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kumar, H.
Right arrow Articles by Bockenstedt, L. K.
The Journal of Immunology, 2000, 165: 4797-4801.
Copyright © 2000 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi1

Hemant Kumar*, Alexia Belperron*, Stephen W. Barthold{dagger} and Linda K. Bockenstedt2,*

* Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520; and the {dagger} Center of Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis, CA 95616

CD1 molecules can present microbial lipid Ag to T cells, suggesting that they participate in host defense against pathogens. In this study, we examined the role of CD1d in resistance to infection with the Lyme disease spirochete, Borrelia burgdorferi (Bb), an organism with proinflammatory lipid Ag. Bb infection of CD1d-deficient (CD1d-/-) mouse strains normally resistant to this pathogen resulted in arthritis. Pathology correlated with an increased prevalence of spirochete DNA in tissues and enhanced production of Bb-specific IgG, including IgG to Ag rapidly down-modulated on spirochetes in vivo. CD1d-/- mice exhibited high-titer Bb-specific IgG2a, an isotype commonly induced in disease-susceptible mice but not in the disease-resistant control mice in this study. These results show that CD1d deficiency impairs host resistance to a spirochete pathogen, and are the first example of a mutation that imparts Bb-resistant mice with the Ab and disease profile of a susceptible mouse strain.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
J. B. Foote and J. F. Kearney
Generation of B Cell Memory to the Bacterial Polysaccharide {alpha}-1,3 Dextran
J. Immunol., November 15, 2009; 183(10): 6359 - 6368.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Bialecki, C. Paget, J. Fontaine, M. Capron, F. Trottein, and C. Faveeuw
Role of Marginal Zone B Lymphocytes in Invariant NKT Cell Activation
J. Immunol., May 15, 2009; 182(10): 6105 - 6113.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. M. Olson Jr., T. C. Bates, H. Izadi, J. D. Radolf, S. A. Huber, J. E. Boyson, and J. Anguita
Local Production of IFN-{gamma} by Invariant NKT Cells Modulates Acute Lyme Carditis
J. Immunol., March 15, 2009; 182(6): 3728 - 3734.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Tupin, M. R.-E.-I. Benhnia, Y. Kinjo, R. Patsey, C. J. Lena, M. C. Haller, M. J. Caimano, M. Imamura, C.-H. Wong, S. Crotty, et al.
NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi
PNAS, December 16, 2008; 105(50): 19863 - 19868.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Vas, J. Mattner, S. Richardson, R. Ndonye, J. P. Gaughan, A. Howell, and M. Monestier
Regulatory Roles for NKT Cell Ligands in Environmentally Induced Autoimmunity
J. Immunol., November 15, 2008; 181(10): 6779 - 6788.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Chiba, C. C. Dascher, G. S. Besra, and M. B. Brenner
Rapid NKT Cell Responses Are Self-Terminating during the Course of Microbial Infection
J. Immunol., August 15, 2008; 181(4): 2292 - 2302.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H. L. Stevenson, E. C. Crossley, N. Thirumalapura, D. H. Walker, and N. Ismail
Regulatory Roles of CD1d-Restricted NKT Cells in the Induction of Toxic Shock-Like Syndrome in an Animal Model of Fatal Ehrlichiosis
Infect. Immun., April 1, 2008; 76(4): 1434 - 1444.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. A. Lang, T. S. Devera, and M. L. Lang
Requirement for CD1d expression by B cells to stimulate NKT cell-enhanced antibody production
Blood, February 15, 2008; 111(4): 2158 - 2162.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. A. Belperron, C. M. Dailey, C. J. Booth, and L. K. Bockenstedt
Marginal Zone B-Cell Depletion Impairs Murine Host Defense against Borrelia burgdorferi Infection
Infect. Immun., July 1, 2007; 75(7): 3354 - 3360.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. T. Borchers, N. L. Harris, S. C. Wesselkamper, S. Zhang, Y. Chen, L. Young, and G. W. Lau
The NKG2D-Activating Receptor Mediates Pulmonary Clearance of Pseudomonas aeruginosa.
Infect. Immun., May 1, 2006; 74(5): 2578 - 2586.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. L. Lang and A. Glatman-Freedman
Do CD1-Restricted T Cells Contribute to Antibody-Mediated Immunity against Mycobacterium tuberculosis?
Infect. Immun., February 1, 2006; 74(2): 803 - 809.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
M. S. Vincent, X. Xiong, E. P. Grant, W. Peng, and M. B. Brenner
CD1a-, b-, and c-Restricted TCRs Recognize Both Self and Foreign Antigens
J. Immunol., November 15, 2005; 175(10): 6344 - 6351.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Bilenki, S. Wang, J. Yang, Y. Fan, A. G. Joyee, and X. Yang
NK T Cell Activation Promotes Chlamydia trachomatis Infection In Vivo
J. Immunol., September 1, 2005; 175(5): 3197 - 3206.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. T. Smiley, P. A. Lanthier, K. N. Couper, F. M. Szaba, J. E. Boyson, W. Chen, and L. L. Johnson
Exacerbated Susceptibility to Infection-Stimulated Immunopathology in CD1d-Deficient Mice
J. Immunol., June 15, 2005; 174(12): 7904 - 7911.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. A. Belperron, C. M. Dailey, and L. K. Bockenstedt
Infection-Induced Marginal Zone B Cell Production of Borrelia hermsii-Specific Antibody Is Impaired in the Absence of CD1d
J. Immunol., May 1, 2005; 174(9): 5681 - 5686.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Wu, G.-W. Xing, M. A. Poles, A. Horowitz, Y. Kinjo, B. Sullivan, V. Bodmer-Narkevitch, O. Plettenburg, M. Kronenberg, M. Tsuji, et al.
Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells
PNAS, February 1, 2005; 102(5): 1351 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. S. Duthie, M. Kahn, M. White, R. P. Kapur, and S. J. Kahn
Critical Proinflammatory and Anti-Inflammatory Functions of Different Subsets of CD1d-Restricted Natural Killer T Cells during Trypanosoma cruzi Infection
Infect. Immun., January 1, 2005; 73(1): 181 - 192.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. V. Parekh, A. K. Singh, M. T. Wilson, D. Olivares-Villagomez, J. S. Bezbradica, H. Inazawa, H. Ehara, T. Sakai, I. Serizawa, L. Wu, et al.
Quantitative and Qualitative Differences in the In Vivo Response of NKT Cells to Distinct {alpha}- and {beta}-Anomeric Glycolipids
J. Immunol., September 15, 2004; 173(6): 3693 - 3706.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
R. A. Campos, M. Szczepanik, A. Itakura, M. Akahira-Azuma, S. Sidobre, M. Kronenberg, and P. W. Askenase
Cutaneous Immunization Rapidly Activates Liver Invariant V{alpha}14 NKT Cells Stimulating B-1 B Cells to Initiate T Cell Recruitment for Elicitation of Contact Sensitivity
J. Exp. Med., December 15, 2003; 198(12): 1785 - 1796.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Skold and S. M. Behar
Role of CD1d-Restricted NKT Cells in Microbial Immunity
Infect. Immun., October 1, 2003; 71(10): 5447 - 5455.
[Full Text] [PDF]

Home page
 JEMHome page
T. Chun, M. J. Page, L. Gapin, J. L. Matsuda, H. Xu, H. Nguyen, H.-S. Kang, A. K. Stanic, S. Joyce, W. A. Koltun, et al.
CD1d-expressing Dendritic Cells but Not Thymic Epithelial Cells Can Mediate Negative Selection of NKT Cells
J. Exp. Med., April 7, 2003; 197(7): 907 - 918.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Huber, D. Sartini, and M. Exley
Role of CD1d in Coxsackievirus B3-Induced Myocarditis
J. Immunol., March 15, 2003; 170(6): 3147 - 3153.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. L. Gansert, V. Kiebler, M. Engele, F. Wittke, M. Rollinghoff, A. M. Krensky, S. A. Porcelli, R. L. Modlin, and S. Stenger
Human NKT Cells Express Granulysin and Exhibit Antimycobacterial Activity
J. Immunol., March 15, 2003; 170(6): 3154 - 3161.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. R. Johnson, R. A. Parker, J. E. Johnson, and B. S. Graham
IL-13 Is Sufficient for Respiratory Syncytial Virus G Glycoprotein-Induced Eosinophilia After Respiratory Syncytial Virus Challenge
J. Immunol., February 15, 2003; 170(4): 2037 - 2045.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Grubor-Bauk, A. Simmons, G. Mayrhofer, and P. G. Speck
Impaired Clearance of Herpes Simplex Virus Type 1 From Mice Lacking CD1d or NKT Cells Expressing the Semivariant V{alpha}14-J{alpha}281 TCR
J. Immunol., February 1, 2003; 170(3): 1430 - 1434.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
T. R. Johnson, S. Hong, L. Van Kaer, Y. Koezuka, and B. S. Graham
NK T Cells Contribute to Expansion of CD8+ T Cells and Amplification of Antiviral Immune Responses to Respiratory Syncytial Virus
J. Virol., March 27, 2002; 76(9): 4294 - 4303.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J. E. Gumperz, S. Miyake, T. Yamamura, and M. B. Brenner
Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining
J. Exp. Med., March 4, 2002; 195(5): 625 - 636.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. W. Jahng, I. Maricic, B. Pedersen, N. Burdin, O. Naidenko, M. Kronenberg, Y. Koezuka, and V. Kumar
Activation of Natural Killer T Cells Potentiates or Prevents Experimental Autoimmune Encephalomyelitis
J. Exp. Med., December 17, 2001; 194(12): 1789 - 1799.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. K. Singh, M. T. Wilson, S. Hong, D. Olivares-Villagomez, C. Du, A. K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, and L. Van Kaer
Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis
J. Exp. Med., December 17, 2001; 194(12): 1801 - 1811.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
S.M. Rhind
CD1--The Pathology Perspective
Vet. Pathol., November 1, 2001; 38(6): 611 - 619.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
B. Wang, Y.-B. Geng, and C.-R. Wang
Cd1-Restricted Nk T Cells Protect Nonobese Diabetic Mice from Developing Diabetes
J. Exp. Med., August 6, 2001; 194(3): 313 - 320.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. Motsinger, D. W. Haas, A. K. Stanic, L. Van Kaer, S. Joyce, and D. Unutmaz
CD1d-restricted Human Natural Killer T Cells Are Highly Susceptible to Human Immunodeficiency Virus 1 Infection
J. Exp. Med., April 1, 2002; 195(7): 869 - 879.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.