The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Graca, L.
Right arrow Articles by Waldmann, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Graca, L.
Right arrow Articles by Waldmann, H.
The Journal of Immunology, 2000, 165: 4783-4786.
Copyright © 2000 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance1

Luis Graca2,3, Karen Honey2, Elizabeth Adams, Stephen P. Cobbold and Herman Waldmann

Sir William Dunn School of Pathology, Oxford, United Kingdom

Nondepleting anti-CD154 (CD40 ligand) mAbs have proven effective in inducing transplantation tolerance in rodents and primates. In the induction phase, anti-CD154 Ab therapy is known to enhance apoptosis of Ag reactive T cells. However, this may not be the sole explanation for tolerance, as we show in this study that tolerance is maintained through a dominant regulatory mechanism which, like tolerance induced with CD4 Abs, manifests as infectious tolerance. Therefore, tolerance induced with anti-CD154 Abs involves not only the deletion of potentially aggressive T cells, but also a contagious spread of tolerance to new cohorts of graft-reactive T cells as they arise.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
C. R. Gilson, Z. Milas, S. Gangappa, D. Hollenbaugh, T. C. Pearson, M. L. Ford, and C. P. Larsen
Anti-CD40 Monoclonal Antibody Synergizes with CTLA4-Ig in Promoting Long-Term Graft Survival in Murine Models of Transplantation
J. Immunol., August 1, 2009; 183(3): 1625 - 1635.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
X. Huang, D. J. Moore, R. J. Ketchum, C. S. Nunemaker, B. Kovatchev, A. L. McCall, and K. L. Brayman
Resolving the Conundrum of Islet Transplantation by Linking Metabolic Dysregulation, Inflammation, and Immune Regulation
Endocr. Rev., August 1, 2008; 29(5): 603 - 630.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Li, L. Ma, D. Yin, J. Shen, and A. S. Chong
Long-Term Control of Alloreactive B Cell Responses by the Suppression of T Cell Help
J. Immunol., May 1, 2008; 180(9): 6077 - 6084.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. B. Thornley, N. E. Phillips, B. C. Beaudette-Zlatanova, T. G. Markees, K. Bahl, M. A. Brehm, L. D. Shultz, E. A. Kurt-Jones, J. P. Mordes, R. M. Welsh, et al.
Type 1 IFN Mediates Cross-Talk between Innate and Adaptive Immunity That Abrogates Transplantation Tolerance
J. Immunol., November 15, 2007; 179(10): 6620 - 6629.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. J. Callaghan, F. J. Rouhani, M. C. Negus, A. J. Curry, E. M. Bolton, J. A. Bradley, and G. J. Pettigrew
Abrogation of Antibody-Mediated Allograft Rejection by Regulatory CD4 T Cells with Indirect Allospecificity
J. Immunol., February 15, 2007; 178(4): 2221 - 2228.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Toda and C. A. Piccirillo
Development and function of naturally occurring CD4+CD25+ regulatory T cells
J. Leukoc. Biol., September 1, 2006; 80(3): 458 - 470.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Zhai, L. Meng, F. Gao, Y. Wang, R. W. Busuttil, and J. W. Kupiec-Weglinski
CD4+ T Regulatory Cell Induction and Function in Transplant Recipients after CD154 Blockade Is TLR4 Independent
J. Immunol., May 15, 2006; 176(10): 5988 - 5994.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Deng, D. J. Moore, X. Huang, M. Mohiuddin, M. K. Lee IV, E. Velidedeoglu, M.-M. Lian, M. Chiaccio, S. Sonawane, A. Orlin, et al.
Antibody-induced transplantation tolerance that is dependent on thymus-derived regulatory T cells.
J. Immunol., March 1, 2006; 176(5): 2799 - 2807.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. R. O. Salvalaggio, G. Camirand, C. E. Ariyan, S. Deng, L. Rogozinski, G. P. Basadonna, and D. M. Rothstein
Antigen Exposure during Enhanced CTLA-4 Expression Promotes Allograft Tolerance In Vivo
J. Immunol., February 15, 2006; 176(4): 2292 - 2298.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. A. Nanji, W. W. Hancock, B. Luo, C. D. Schur, R. L. Pawlick, L. F. Zhu, C. C. Anderson, and A.M. J. Shapiro
Costimulation Blockade of Both Inducible Costimulator and CD40 Ligand Induces Dominant Tolerance to Islet Allografts and Prevents Spontaneous Autoimmune Diabetes in the NOD Mouse
Diabetes, January 1, 2006; 55(1): 27 - 33.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Delgado, E. Gonzalez-Rey, and D. Ganea
The Neuropeptide Vasoactive Intestinal Peptide Generates Tolerogenic Dendritic Cells
J. Immunol., December 1, 2005; 175(11): 7311 - 7324.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. S. Krupnick, A. E. Gelman, W. Barchet, S. Richardson, F. H. Kreisel, L. A. Turka, M. Colonna, G. A. Patterson, and D. Kreisel
Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells
J. Immunol., November 15, 2005; 175(10): 6265 - 6270.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
S. P Cobbold
T cell tolerance induced by therapeutic antibodies
Phil Trans R Soc B, September 29, 2005; 360(1461): 1695 - 1705.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
S. P Hickman and L. A Turka
Homeostatic T cell proliferation as a barrier to T cell tolerance
Phil Trans R Soc B, September 29, 2005; 360(1461): 1713 - 1721.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. A. Quezada, K. Bennett, B. R. Blazar, A. Y. Rudensky, S. Sakaguchi, and R. J. Noelle
Analysis of the Underlying Cellular Mechanisms of Anti-CD154-Induced Graft Tolerance: The Interplay of Clonal Anergy and Immune Regulation
J. Immunol., July 15, 2005; 175(2): 771 - 779.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
I. Lee, L. Wang, A. D. Wells, M. E. Dorf, E. Ozkaynak, and W. W. Hancock
Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor
J. Exp. Med., April 4, 2005; 201(7): 1037 - 1044.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Zhou, S. J. Balin, M. Mashayekhi, K. W. Hwang, D. A. Palucki, and M.-L. Alegre
Transplantation Tolerance in NF-{kappa}B-Impaired Mice Is Not Due to Regulation but Is Prevented by Transgenic Expression of Bcl-xL
J. Immunol., March 15, 2005; 174(6): 3447 - 3453.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. H. Albert, X.-Z. Yu, P. J. Martin, and C. Anasetti
Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin
Blood, February 1, 2005; 105(3): 1355 - 1361.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Metzler, P. Gfeller, M. Bigaud, J. Li, G. Wieczorek, C. Heusser, P. Lake, and A. Katopodis
Combinations of Anti-LFA-1, Everolimus, Anti-CD40 Ligand, and Allogeneic Bone Marrow Induce Central Transplantation Tolerance through Hemopoietic Chimerism, Including Protection from Chronic Heart Allograft Rejection
J. Immunol., December 1, 2004; 173(11): 7025 - 7036.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Nagelkerken, I. Haspels, W. van Rijs, B. Blauw, J. L. Ferrant, D. M. Hess, E. A. Garber, F. R. Taylor, and L. C. Burkly
FcR Interactions Do Not Play a Major Role in Inhibition of Experimental Autoimmune Encephalomyelitis by Anti-CD154 Monoclonal Antibodies
J. Immunol., July 15, 2004; 173(2): 993 - 999.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Vigouroux, E. Yvon, E. Biagi, and M. K. Brenner
Antigen-induced regulatory T cells
Blood, July 1, 2004; 104(1): 26 - 33.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Kurtz, J. Shaffer, A. Lie, N. Anosova, G. Benichou, and M. Sykes
Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells
Blood, June 1, 2004; 103(11): 4336 - 4343.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T.-C. Chen, S. P. Cobbold, P. J. Fairchild, and H. Waldmann
Generation of Anergic and Regulatory T Cells following Prolonged Exposure to a Harmless Antigen
J. Immunol., May 15, 2004; 172(10): 5900 - 5907.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. P. Cobbold, R. Castejon, E. Adams, D. Zelenika, L. Graca, S. Humm, and H. Waldmann
Induction of foxP3+ Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants
J. Immunol., May 15, 2004; 172(10): 6003 - 6010.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. van Maurik, B. F. de St. Groth, K. J. Wood, and N. D. Jones
Dependency of Direct Pathway CD4+ T Cells on CD40-CD154 Costimulation Is Determined by Nature and Microenvironment of Primary Contact with Alloantigen
J. Immunol., February 15, 2004; 172(4): 2163 - 2170.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. A. Quezada, B. Fuller, L. Z. Jarvinen, M. Gonzalez, B. R. Blazar, A. Y. Rudensky, T. B. Strom, and R. J. Noelle
Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation
Blood, September 1, 2003; 102(5): 1920 - 1926.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. E. Phillips, T. G. Markees, J. P. Mordes, D. L. Greiner, and A. A. Rossini
Blockade of CD40-Mediated Signaling Is Sufficient for Inducing Islet But Not Skin Transplantation Tolerance
J. Immunol., March 15, 2003; 170(6): 3015 - 3023.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C. Mauri, D. Gray, N. Mushtaq, and M. Londei
Prevention of Arthritis by Interleukin 10-producing B Cells
J. Exp. Med., February 17, 2003; 197(4): 489 - 501.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. v. Maurik, M. Herber, K. J. Wood, and N. D. Jones
Cutting Edge: CD4+CD25+ Alloantigen-Specific Immunoregulatory Cells That Can Prevent CD8+ T Cell-Mediated Graft Rejection: Implications for Anti-CD154 Immunotherapy
J. Immunol., November 15, 2002; 169(10): 5401 - 5404.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. R. Nicolls, M. Coulombe, J. Beilke, H. C. Gelhaus, and R. G. Gill
CD4-Dependent Generation of Dominant Transplantation Tolerance Induced by Simultaneous Perturbation of CD154 and LFA-1 Pathways
J. Immunol., November 1, 2002; 169(9): 4831 - 4839.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. Graca, S. P. Cobbold, and H. Waldmann
Identification of Regulatory T Cells in Tolerated Allografts
J. Exp. Med., June 17, 2002; 195(12): 1641 - 1646.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Graca, S. Thompson, C.-Y. Lin, E. Adams, S. P. Cobbold, and H. Waldmann
Both CD4+CD25+ and CD4+CD25- Regulatory Cells Mediate Dominant Transplantation Tolerance
J. Immunol., June 1, 2002; 168(11): 5558 - 5565.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Yamada, A. Chandraker, T. M. Laufer, A. J. Gerth, M. H. Sayegh, and H. Auchincloss Jr.
Cutting Edge: Recipient MHC Class II Expression Is Required to Achieve Long-Term Survival of Murine Cardiac Allografts After Costimulatory Blockade
J. Immunol., November 15, 2001; 167(10): 5522 - 5526.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Pimenta-Araujo, L. Mascarell, M. Huesca, A. Cumano, and A. Bandeira
Embryonic Thymic Epithelium Naturally Devoid of APCs Is Acutely Rejected in the Absence of Indirect Recognition
J. Immunol., November 1, 2001; 167(9): 5034 - 5041.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Gregori, M. Casorati, S. Amuchastegui, S. Smiroldo, A. M. Davalli, and L. Adorini
Regulatory T Cells Induced by 1{alpha},25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance
J. Immunol., August 15, 2001; 167(4): 1945 - 1953.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.