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CUTTING EDGE |
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520
TGF-ß is an important immunomodulatory cytokine that can inhibit differentiation of effector T cells. In this report, we address the molecular mechanisms through which TGF-ß inhibits differentiation of CD4+ cells into Th type 2 cells. We demonstrate that TGF-ß inhibits GATA-3 expression in developing Th cells. We also show that inhibition of GATA-3 expression by TGF-ß is a major mechanism of inhibition of Th2 differentiation by TGF-ß as ectopic expression of GATA-3 in developing T cells overcomes the ability of TGF-ß to inhibit Th2 differentiation. TGF-ß likely inhibits GATA-3 expression at the transcriptional level and does so without interfering with IL-4 signaling.
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