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5, v, and 4 Integrins1
*
Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115
Mice chimeric for integrins 
5,
V, or 4 were used to dissect the in vivo
roles of these adhesion receptors during leukocyte development and
traffic. No major defects were observed in the development of
lymphocytes, monocytes, or granulocytes or in the traffic of
lymphocytes to different lymphoid organs in the absence of
5 or V integrins. However, in agreement
with previous reports, the absence of 4 integrins
produced major defects in development of lymphoid and myeloid lineages
and a specific defect in homing of lymphocytes to Peyer’s patches. In
contrast, the 4 integrin subunit is not essential for
localization of T lymphocytes into intraepithelial and lamina propria
compartments in the gut, whereas one of the partners of
4, the ß7 chain, has been shown to be
essential. However, 4-deficient T lymphocytes cannot
migrate properly during the inflammatory response induced by
thioglycolate injection into the peritoneum. Finally, in vitro
proliferation and activation of lymphocytes deficient for
5, V, or 4 integrins upon
stimulation with different stimuli were similar to those seen in
controls. These results show that integrins play distinct roles during
in vivo leukocyte development and traffic.
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