| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Centre for Inflammatory Diseases, Department of Medicine Monash Medical Centre, Monash University, Clayton, Victoria, Australia; and
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Fujisaki, Okayama, Japan
IL-18 (formerly known as IFN-
-inducing factor) enhances Th1
responses via effects that are thought to be dependent on and
synergistic with IL-12. The potential for IL-18 to exert
IL-12-independent effects in delayed-type hypersensitivity (DTH)
responses was studied in a model of Th1-directed, DTH-mediated
crescentic glomerulonephritis induced by planting an Ag in glomeruli of
sensitized mice as well as in cutaneous DTH. Sensitized genetically
normal (IL-12+/+) mice developed proteinuria and crescentic
glomerulonephritis with a glomerular influx of DTH effectors
(CD4+ T cells, macrophages, and fibrin deposition) in
response to the planted glomerular Ag. IL-12p40-deficient
(IL-12-/-) mice showed significant reductions in crescent
formation, proteinuria, and glomerular DTH effectors. Administration of
IL-18 to IL-12-/- mice restored the development of
histological (including effectors of DTH) and functional glomerular
injury in IL-12-/- mice to levels equivalent to those in
IL-12+/+ mice. IL-18 administration to
IL-12-/- mice increased glomerular ICAM-1 protein
expression, but did not restore Ag-stimulated splenocyte IFN-,
GM-CSF, IL-2, or TNF-
production. Sensitized IL-12+/+
mice also developed cutaneous DTH following intradermal challenge with
the nephritogenic Ag. Cutaneous DTH was inhibited in
IL-12-/- mice, but was restored by administration of
IL-18. IL-12+/+ mice given IL-18 developed augmented
injury, with enhanced glomerular and cutaneous DTH, demonstrating the
synergistic effects of IL-18 and IL-12 in DTH responses. These studies
demonstrate that even in the absence of IL-12, IL-18 can induce in vivo
DTH responses and up-regulate ICAM-1 without inducing IFN-, GM-CSF,
or TNF- production.
This article has been cited by other articles:
|
|
 |
|
  H.-T. LEE, W.-S. CHEN, K.-H. SUN, C.-T. CHOU, and C.-Y. TSAI Increased Spontaneous But Decreased Mitogen-stimulated Expression and Excretion of Interleukin 18 by Mononuclear Cells in Patients with Active Systemic Lupus Erythematosus J Rheumatol, September 1, 2009; 36(9): 1910 - 1916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Miyashita, Y. Obase, K. Ouchi, K. Kawasaki, Y. Kawai, Y. Kobashi, and M. Oka Clinical features of severe Mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit J. Med. Microbiol., December 1, 2007; 56(12): 1625 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-W. Chen, H.-T. Kuo, C.-Y. Chai, J.-L. Ou, and R.-C. Yang Pretreatment of curcumin attenuates coagulopathy and renal injury in LPS-induced endotoxemia Innate Immunity, February 1, 2007; 13(1): 15 - 23. [Abstract] [PDF]
|
|
|
|
 |
|
 P. G. Tipping and S. R. Holdsworth T Cells in Crescentic Glomerulonephritis J. Am. Soc. Nephrol., May 1, 2006; 17(5): 1253 - 1263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Young, M. T. Borchers, H. L. Allen, R. S. Gibbons, and F. X. McCormack Lung-Restricted Macrophage Activation in the Pearl Mouse Model of Hermansky-Pudlak Syndrome J. Immunol., April 1, 2006; 176(7): 4361 - 4368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Kitching, A. L. Turner, G. R.A. Wilson, T. Semple, D. Odobasic, J. R. Timoshanko, K. M. O'Sullivan, P. G. Tipping, K. Takeda, S. Akira, et al. IL-12p40 and IL-18 in Crescentic Glomerulonephritis: IL-12p40 is the Key Th1-Defining Cytokine Chain, Whereas IL-18 Promotes Local Inflammation and Leukocyte Recruitment J. Am. Soc. Nephrol., July 1, 2005; 16(7): 2023 - 2033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Q. Gao, Y. Tsuda, K. Katayama, T. Nakayama, Y. Hatanaka, Y. Tani, H. Mizuguchi, T. Hayakawa, O. Yoshie, Y. Tsutsumi, et al. Antitumor Effect by Interleukin-11 Receptor {alpha}-Locus Chemokine/CCL27, Introduced into Tumor Cells through a Recombinant Adenovirus Vector Cancer Res., August 1, 2003; 63(15): 4420 - 4425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tanaka, M. Narita, S. Teramoto, T. Saikai, K. Oashi, T. Igarashi, and S. Abe Role of Interleukin-18 and T-helper Type 1 Cytokines in the Development of Mycoplasma pneumoniae Pneumonia in Adults* Chest, May 1, 2002; 121(5): 1493 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Wang, C. Feliciani, B. G. Howell, I. Freed, Q. Cai, H. Watanabe, and D. N. Sauder Contribution of Langerhans Cell-Derived IL-18 to Contact Hypersensitivity J. Immunol., April 1, 2002; 168(7): 3303 - 3308. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
