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*
Fugu Genomics, HGMP Resource Centre, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom;
Institut de Cancérologie et d’Immunologie de Marseille, Institut National de la Santé et de la Recherche Médicale Unité 119, Marseille, France;
UPRES Biodiversité 2202, Laboratoire d’hydrobiologie, Université de Provence, Marseille, France; and
§
Department of Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom
The low molecular mass polypeptide (LMP2, LMP7, and MECL-1) genes
code for ß-type subunits of the proteasome, a multimeric complex that
degrades proteins into peptides as part of the MHC class I-mediated
Ag-presenting pathway. These gene products are up-regulated in response
to infection by IFN-
and replace the corresponding constitutively
expressed subunits (X, Y, and Z) during the immune response. In humans,
the LMP2 and LMP7 genes both reside within the class II region of the
MHC (6p21.3), while MECL-1 is located at 16q22.1. In the present study,
we have identified all three IFN--regulated ß-type proteasome
subunits in Fugu, which are present as a cluster within
the Fugu MHC class I region. We show that in this
species, LMP7, LMP2, and MECL-1 are linked. Also within this cluster is
an LMP2-like subunit (which seems specific to all teleosts tested to
date) and a closely linked LMP7 pseudogene, indicating that within
Fugu and potentially other teleosts, there has been an
additional regional duplication involving these
genes.
This article has been cited by other articles:
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