| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Faculty of Medicine, Department of Immunology, Technion, Haifa, Israel; and
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037
In the B lymphocyte lineage, Fas-mediated cell death is important in controlling activated mature cells, but little is known about possible functions at earlier developmental stages. In this study we found that in mice lacking the IgM transmembrane tail exons (µMT mice), in which B cell development is blocked at the pro-B stage, the absence of Fas or Fas ligand allows significant B cell development and maturation, resulting in high serum Ig levels. These B cells demonstrate Ig heavy chain isotype switching and autoimmune reactivity, suggesting that lack of functional Fas allows maturation of defective and/or self-reactive B cells in µMT/lpr mice. Possible mechanisms that may allow maturation of these B cells are discussed.
This article has been cited by other articles:
|
|
 |
|
  E. Edry, H. Azulay-Debby, and D. Melamed TOLL-like receptor ligands stimulate aberrant class switch recombination in early B cell precursors Int. Immunol., December 1, 2008; 20(12): 1575 - 1585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Perona-Wright, K. Mohrs, J. Taylor, C. Zaph, D. Artis, E. J. Pearce, and M. Mohrs Cutting Edge: Helminth Infection Induces IgE in the Absence of {micro}- or {delta}-Chain Expression J. Immunol., November 15, 2008; 181(10): 6697 - 6701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Edry, S. B. Koralov, K. Rajewsky, and D. Melamed Spontaneous Class Switch Recombination in B Cell Lymphopoiesis Generates Aberrant Switch Junctions and Is Increased after VDJ Rearrangement J. Immunol., November 15, 2007; 179(10): 6555 - 6560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Choudhury, P. L. Cohen, and R. A. Eisenberg Mature B Cells Preferentially Lose Tolerance in the Chronic Graft-versus-Host Disease Model of Systemic Lupus Erythematosus J. Immunol., October 15, 2007; 179(8): 5564 - 5570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jiang, J. Foley, N. Clayton, G. Kissling, M. Jokinen, R. Herbert, and M. Diaz Abrogation of Lupus Nephritis in Activation-Induced Deaminase-Deficient MRL/lpr Mice J. Immunol., June 1, 2007; 178(11): 7422 - 7431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ueda, D. Liao, K. Yang, A. Patel, and G. Kelsoe T-Independent Activation-Induced Cytidine Deaminase Expression, Class-Switch Recombination, and Antibody Production by Immature/Transitional 1 B Cells J. Immunol., March 15, 2007; 178(6): 3593 - 3601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Butler and N. Wertz Antibody Repertoire Development in Fetal and Neonatal Piglets. XVII. IgG Subclass Transcription Revisited with Emphasis on New IgG3 J. Immunol., October 15, 2006; 177(8): 5480 - 5489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M Strutt, J. Uzonna, K. K McKinstry, and P. A Bretscher Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC Int. Immunol., May 1, 2006; 18(5): 719 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Edry and D. Melamed Receptor Editing in Positive and Negative Selection of B Lymphopoiesis J. Immunol., October 1, 2004; 173(7): 4265 - 4271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Nanni, L. Landuzzi, G. Nicoletti, C. De Giovanni, I. Rossi, S. Croci, A. Astolfi, M. Iezzi, E. Di Carlo, P. Musiani, et al. Immunoprevention of Mammary Carcinoma in HER-2/neu Transgenic Mice Is IFN-{gamma} and B Cell Dependent J. Immunol., August 15, 2004; 173(4): 2288 - 2296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Seagal, E. Edry, H. Naftali, and D. Melamed Generation and selection of an IgG-driven autoimmune repertoire during B-lymphopoiesis in Ig{micro}-deficient/lpr mice Int. Immunol., July 1, 2004; 16(7): 905 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Marquina, M. A. Diez, M. Lopez-Hoyos, L. Buelta, A. Kuroki, S. Kikuchi, J. Villegas, M. Pihlgren, C.-A. Siegrist, M. Arias, et al. Inhibition of B Cell Death Causes the Development of an IgA Nephropathy in (New Zealand White x C57BL/6)F1-bcl-2 Transgenic Mice J. Immunol., June 1, 2004; 172(11): 7177 - 7185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Seagal, E. Edry, Z. Keren, N. Leider, O. Benny, M. Machluf, and D. Melamed A Fail-safe Mechanism for Negative Selection of Isotype-switched B Cell Precursors Is Regulated by the Fas/FasL Pathway J. Exp. Med., November 17, 2003; 198(10): 1609 - 1619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Seagal, N. Leider, G. Wildbaum, N. Karin, and D. Melamed Increased plasma cell frequency and accumulation of abnormal syndecan-1plus T-cells in Ig{micro}-deficient/lpr mice Int. Immunol., September 1, 2003; 15(9): 1045 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shivtiel, N. Leider, O. Sadeh, Z. Kraiem, and D. Melamed Impaired Light Chain Allelic Exclusion and Lack of Positive Selection in Immature B Cells Expressing Incompetent Receptor Deficient of CD19 J. Immunol., June 1, 2002; 168(11): 5596 - 5604. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
