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*
Faculty of Medicine, Department of Immunology, Technion, Haifa, Israel; and
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037
In the B lymphocyte lineage, Fas-mediated cell death is important in controlling activated mature cells, but little is known about possible functions at earlier developmental stages. In this study we found that in mice lacking the IgM transmembrane tail exons (µMT mice), in which B cell development is blocked at the pro-B stage, the absence of Fas or Fas ligand allows significant B cell development and maturation, resulting in high serum Ig levels. These B cells demonstrate Ig heavy chain isotype switching and autoimmune reactivity, suggesting that lack of functional Fas allows maturation of defective and/or self-reactive B cells in µMT/lpr mice. Possible mechanisms that may allow maturation of these B cells are discussed.
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