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The Journal of Immunology, 2000, 165: 4305-4311.
Copyright © 2000 by The American Association of Immunologists

Selective Bystander Proliferation of Memory CD4+ and CD8+ T Cells Upon NK T or T Cell Activation

Gérard Eberl, Pierre Brawand and H. Robson MacDonald1

Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland

Ag-experienced or memory T cells have increased reactivity to recall Ag, and can be distinguished from naive T cells by altered expression of surface markers such as CD44. Memory T cells have a high turnover rate, and CD8+ memory T cells proliferate upon viral infection, in the presence of IFN-{alpha}ß and/or IL-15. In this study, we extend these findings by showing that activated NKT cells and superantigen-activated T cells induce extensive bystander proliferation of both CD8+ and CD4+ memory T cells. Moreover, proliferation of memory T cells can be induced by an IFN-{alpha}ß-independent, but IFN-{gamma}- or IL-12-dependent pathway. In these conditions of bystander activation, proliferating memory (CD44high) T cells do not derive from activation of naive (CD44low) T cells, but rather from bona fide memory CD44high T cells. Together, these data demonstrate that distinct pathways can induce bystander proliferation of memory T cells.




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