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*
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, and
Ear, Nose and Throat Department, University of Oslo, Rikshospitalet, Oslo, Norway; and
Becton Dickinson Immunocytometry Systems, San Jose, CA 95131
<. >
Recent evidence suggests that the previously enigmatic cell
type designated plasmacytoid monocytes can function as dendritic cells
and contribute substantially to both innate and adaptive immunity. This
cell type has previously been described only in bone marrow, blood, and
organized lymphoid tissue, but not at effector sites with direct Ag
exposure such as the mucosae. Plasmacytoid dendritic cells (P-DCs)
matured in vitro can induce T cells to produce allergy-promoting Th2
cytokines; therefore, their possible occurrence in nasal mucosa during
experimentally elicited allergic rhinitis was examined. Patients with
silent nasal allergy were challenged topically with relevant allergen
daily for 7 days. Biopsy specimens as well as blood samples were
obtained before and during such provocation, and P-DCs were identified
by their high expression of CD123 (IL-3R 
-chain), together with
CD45RA. Our results showed that P-DCs were present in low and variable
numbers in normal nasal mucosa but increased dramatically during the
allergic reaction. This accumulation concurred with the expression of
the L-selectin ligand peripheral lymph node addressin on the mucosal
vascular endothelium. The latter observation was particularly
interesting in view of the high levels of L-selectin on circulating
P-DC precursors and of previous reports suggesting that these cells can
enter organized lymphoid tissue via high endothelial venules (which
express peripheral lymph node addressin constitutively). Together, our
findings suggested that P-DCs are involved in the triggering of airway
allergy and that they are directed to allergic lesions by adhesion
molecules that normally mediate leukocyte extravasation in organized
lymphoid tissue.
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R. Lande, E. Giacomini, B. Serafini, B. Rosicarelli, G. D. Sebastiani, G. Minisola, U. Tarantino, V. Riccieri, G. Valesini, and E. M. Coccia Characterization and Recruitment of Plasmacytoid Dendritic Cells in Synovial Fluid and Tissue of Patients with Chronic Inflammatory Arthritis J. Immunol., August 15, 2004; 173(4): 2815 - 2824. [Abstract] [Full Text] [PDF]
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J.-F. Fonteneau, M. Larsson, A.-S. Beignon, K. McKenna, I. Dasilva, A. Amara, Y.-J. Liu, J. D. Lifson, D. R. Littman, and N. Bhardwaj Human Immunodeficiency Virus Type 1 Activates Plasmacytoid Dendritic Cells and Concomitantly Induces the Bystander Maturation of Myeloid Dendritic Cells J. Virol., May 15, 2004; 78(10): 5223 - 5232. [Abstract] [Full Text] [PDF]
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S. Pichyangkul, K. Yongvanitchit, U. Kum-arb, H. Hemmi, S. Akira, A. M. Krieg, D. G. Heppner, V. A. Stewart, H. Hasegawa, S. Looareesuwan, et al. Malaria Blood Stage Parasites Activate Human Plasmacytoid Dendritic Cells and Murine Dendritic Cells through a Toll-Like Receptor 9-Dependent Pathway J. Immunol., April 15, 2004; 172(8): 4926 - 4933. [Abstract] [Full Text] [PDF]
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T. Ito, R. Amakawa, M. Inaba, T. Hori, M. Ota, K. Nakamura, M. Takebayashi, M. Miyaji, T. Yoshimura, K. Inaba, et al. Plasmacytoid Dendritic Cells Regulate Th Cell Responses through OX40 Ligand and Type I IFNs J. Immunol., April 1, 2004; 172(7): 4253 - 4259. [Abstract] [Full Text] [PDF]
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N. J. Megjugorac, H. A. Young, S. B. Amrute, S. L. Olshalsky, and P. Fitzgerald-Bocarsly Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells J. Leukoc. Biol., March 1, 2004; 75(3): 504 - 514. [Abstract] [Full Text] [PDF]
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M. Schnurr, T. Toy, A. Shin, G. Hartmann, S. Rothenfusser, J. Soellner, I. D. Davis, J. Cebon, and E. Maraskovsky Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells Blood, February 15, 2004; 103(4): 1391 - 1397. [Abstract] [Full Text] [PDF]
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F. L. Jahnsen, E. Gran, R. Haye, and P. Brandtzaeg Human Nasal Mucosa Contains Antigen-Presenting Cells of Strikingly Different Functional Phenotypes Am. J. Respir. Cell Mol. Biol., January 1, 2004; 30(1): 31 - 37. [Abstract] [Full Text] [PDF]
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C. Asselin-Paturel, G. Brizard, J.-J. Pin, F. Briere, and G. Trinchieri Mouse Strain Differences in Plasmacytoid Dendritic Cell Frequency and Function Revealed by a Novel Monoclonal Antibody J. Immunol., December 15, 2003; 171(12): 6466 - 6477. [Abstract] [Full Text] [PDF]
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A. K. Palucka, J. Gatlin, J. P. Blanck, M. W. Melkus, S. Clayton, H. Ueno, E. T. Kraus, P. Cravens, L. Bennett, A. Padgett-Thomas, et al. Human dendritic cell subsets in NOD/SCID mice engrafted with CD34+ hematopoietic progenitors Blood, November 1, 2003; 102(9): 3302 - 3310. [Abstract] [Full Text] [PDF]
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 E. Hartmann, B. Wollenberg, S. Rothenfusser, M. Wagner, D. Wellisch, B. Mack, T. Giese, O. Gires, S. Endres, and G. Hartmann Identification and Functional Analysis of Tumor-Infiltrating Plasmacytoid Dendritic Cells in Head and Neck Cancer Cancer Res., October 1, 2003; 63(19): 6478 - 6487. [Abstract] [Full Text] [PDF]
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B. Vanbervliet, N. Bendriss-Vermare, C. Massacrier, B. Homey, O. de Bouteiller, F. Briere, G. Trinchieri, and C. Caux The Inducible CXCR3 Ligands Control Plasmacytoid Dendritic Cell Responsiveness to the Constitutive Chemokine Stromal Cell-derived Factor 1 (SDF-1)/CXCL12 J. Exp. Med., September 2, 2003; 198(5): 823 - 830. [Abstract] [Full Text] [PDF]
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 E. S. Baekkevold, M. Roussigne, T. Yamanaka, F.-E. Johansen, F. L. Jahnsen, F. Amalric, P. Brandtzaeg, M. Erard, G. Haraldsen, and J.-P. Girard Molecular Characterization of NF-HEV, a Nuclear Factor Preferentially Expressed in Human High Endothelial Venules Am. J. Pathol., July 1, 2003; 163(1): 69 - 79. [Abstract] [Full Text] [PDF]
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G. de la Rosa, N. Longo, J. L. Rodriguez-Fernandez, A. Puig-Kroger, A. Pineda, A. L. Corbi, and P. Sanchez-Mateos Migration of human blood dendritic cells across endothelial cell monolayers: adhesion molecules and chemokines involved in subset-specific transmigration J. Leukoc. Biol., May 1, 2003; 73(5): 639 - 649. [Abstract] [Full Text] [PDF]
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J.-F. Fonteneau, M. Gilliet, M. Larsson, I. Dasilva, C. Munz, Y.-J. Liu, and N. Bhardwaj Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity Blood, May 1, 2003; 101(9): 3520 - 3526. [Abstract] [Full Text] [PDF]
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A. Mazzoni, C. A. Leifer, G. E. D. Mullen, M. N. Kennedy, D. M. Klinman, and D. M. Segal Cutting Edge: Histamine Inhibits IFN-{alpha} Release from Plasmacytoid Dendritic Cells J. Immunol., March 1, 2003; 170(5): 2269 - 2273. [Abstract] [Full Text] [PDF]
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A.-S. Charbonnier, H. Hammad, P. Gosset, G. A. Stewart, S. Alkan, A.-B. Tonnel, and J. Pestel Der p 1-pulsed myeloid and plasmacytoid dendritic cells from house dust mite-sensitized allergic patients dysregulate the T cell response J. Leukoc. Biol., January 1, 2003; 73(1): 91 - 99. [Abstract] [Full Text] [PDF]
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P. Brawand, D. R. Fitzpatrick, B. W. Greenfield, K. Brasel, C. R. Maliszewski, and T. De Smedt Murine Plasmacytoid Pre-Dendritic Cells Generated from Flt3 Ligand-Supplemented Bone Marrow Cultures Are Immature APCs J. Immunol., December 15, 2002; 169(12): 6711 - 6719. [Abstract] [Full Text] [PDF]
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H. Matsuda, T. Suda, H. Hashizume, K. Yokomura, K. Asada, K. Suzuki, K. Chida, and H. Nakamura Alteration of Balance between Myeloid Dendritic Cells and Plasmacytoid Dendritic Cells in Peripheral Blood of Patients with Asthma Am. J. Respir. Crit. Care Med., October 15, 2002; 166(8): 1050 - 1054. [Abstract] [Full Text] [PDF]
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L. Fong, M. Mengozzi, N. W. Abbey, B. G. Herndier, and E. G. Engleman Productive Infection of Plasmacytoid Dendritic Cells with Human Immunodeficiency Virus Type 1 Is Triggered by CD40 Ligation J. Virol., October 2, 2002; 76(21): 11033 - 11041. [Abstract] [Full Text] [PDF]
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J. H. Ahn, Y. Lee, C. Jeon, S.-J. Lee, B.-H. Lee, K. D. Choi, and Y.-S. Bae Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis Blood, August 13, 2002; 100(5): 1742 - 1754. [Abstract] [Full Text] [PDF]
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E. J. Soilleux, L. S. Morris, G. Leslie, J. Chehimi, Q. Luo, E. Levroney, J. Trowsdale, L. J. Montaner, R. W. Doms, D. Weissman, et al. Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro J. Leukoc. Biol., March 1, 2002; 71(3): 445 - 457. [Abstract] [Full Text] [PDF]
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A. Dzionek, Y. Sohma, J. Nagafune, M. Cella, M. Colonna, F. Facchetti, G. Gunther, I. Johnston, A. Lanzavecchia, T. Nagasaka, et al. BDCA-2, a Novel Plasmacytoid Dendritic Cell-specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon {alpha}/{beta} Induction J. Exp. Med., December 17, 2001; 194(12): 1823 - 1834. [Abstract] [Full Text] [PDF]
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F L Jahnsen, E D Moloney, T Hogan, J W Upham, C M Burke, and P G Holt Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge Thorax, November 1, 2001; 56(11): 823 - 826. [Abstract] [Full Text] [PDF]
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H. Nakano, M. Yanagita, and M. D. Gunn Cd11c+B220+Gr-1+ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells J. Exp. Med., October 15, 2001; 194(8): 1171 - 1178. [Abstract] [Full Text] [PDF]
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G. Penna, S. Sozzani, and L. Adorini Cutting Edge: Selective Usage of Chemokine Receptors by Plasmacytoid Dendritic Cells J. Immunol., August 15, 2001; 167(4): 1862 - 1866. [Abstract] [Full Text] [PDF]
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 S Blomberg, M L Eloranta, B Cederblad, K Nordlind, G L Alm, and L Ronnblom Presence of cutaneous interferon-a producing cells in patients with systemic lupus erythematosus Lupus, July 1, 2001; 10(7): 484 - 490. [Abstract] [PDF]
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L. Farkas, K. Beiske, F. Lund-Johansen, P. Brandtzaeg, and F. L. Jahnsen Plasmacytoid Dendritic Cells (Natural Interferon- {{alpha}}/{beta}-Producing Cells) Accumulate in Cutaneous Lupus Erythematosus Lesions Am. J. Pathol., July 1, 2001; 159(1): 237 - 243. [Abstract] [Full Text] [PDF]
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