| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,
*
Centre de Recherche, Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l’Université Laval, Sainte-Foy (Québec), Canada;
Central Laboratory of The Netherlands Red Cross Blood Transfusion Services, Amsterdam, The Netherlands; and
Department of Clinical Chemistry, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
Numerous lung diseases, such as hypersensitivity pneumonitis (HP),
are characterized by the presence of activated alveolar CTL and NK
cells. Since these cells produce granzymes, granzyme A and B levels in
bronchoalveolar lavage (BAL) fluids from 14 normal subjects and 12
patients with HP were measured by ELISA. Median (range) BAL granzyme A
and B levels were 4 (0–37) and 0 (0–6) pg/ml in normal subjects. BAL
granzyme levels were significantly higher in HP patients, being at 74
(0–1889) and 10 (0–78) pg/ml for granzymes A and B, respectively. In
vitro, neither of the three main serine protease inhibitors of the
lung, namely 
1-antitrypsin, secretory leukocyte
protease inhibitor, and elafin, showed any effect on granzyme A or B
activity. In addition, granzyme A was shown to be fully active in BAL
fluids. Hence, these data show that granzyme activity may be poorly
controlled by protease inhibitors in inflamed tissues. Thus, granzymes
could contribute to tissue remodeling and inflammation characterizing
HP.
This article has been cited by other articles:
|
|
 |
|
  K Bratke, A Klug, P Julius, M Kuepper, M Lommatzsch, G Sparmann, W Luttmann, and J C Virchow Granzyme K: a novel mediator in acute airway inflammation Thorax, November 1, 2008; 63(11): 1006 - 1011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. J. Vernooy, G. M. Moller, R. J. van Suylen, M. P. van Spijk, R. H. E. Cloots, P. H. Hoet, H. J. Pennings, and E. F. M. Wouters Increased Granzyme A Expression in Type II Pneumocytes of Patients with Severe Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., March 1, 2007; 175(5): 464 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Tschopp, N. Spiegl, S. Didichenko, W. Lutmann, P. Julius, J. C. Virchow, C. E. Hack, and C. A. Dahinden Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma Blood, October 1, 2006; 108(7): 2290 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Massaro, G. D. Massaro, A. Baras, E. P. Hoffman, and L. B. Clerch Calorie-related rapid onset of alveolar loss, regeneration, and changes in mouse lung gene expression Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L896 - L906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Tremblay, E. Vachon, C. Larouche, and Y. Bourbonnais Inhibition of Human Neutrophil Elastase-Induced Acute Lung Injury in Hamsters by Recombinant Human Pre-elafin (Trappin-2) Chest, February 1, 2002; 121(2): 582 - 588. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
