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*
Children’s Hospital Medical Center, Division of Pulmonary Biology and Critical Care Medicine, Cincinnati, OH 45229; and
Division of Pulmonary Biology/Critical Care Medicine, University of Colorado, Denver, CO 80262
Mice lacking surfactant protein (SP)-A (SP-A-/-) or SP-D (SP-D-/-) and wild-type mice were infected with group B streptococcus or Haemophilus influenzae by intratracheal instillation. Although decreased killing of group B streptococcus and H. influenzae was observed in SP-A-/- mice but not in SP-D-/- mice, deficiency of either SP-A or SP-D was associated with increased inflammation and inflammatory cell recruitment in the lung after infection. Deficient uptake of bacteria by alveolar macrophages was observed in both SP-A- and SP-D-deficient mice. Isolated alveolar macrophages from SP-A-/- mice generated significantly less, whereas those from SP-D-/- mice generated significantly greater superoxide and hydrogen peroxide compared with wild-type alveolar macrophages. In SP-D-/- mice, bacterial killing was associated with increased lung inflammation, increased oxidant production, and decreased macrophage phagocytosis. In contrast, in the absence of SP-A, bacterial killing was decreased and associated with increased lung inflammation, decreased oxidant production, and decreased macrophage phagocytosis. Increased oxidant production likely contributes to effective bacterial killing in the lungs of SP-D-/- mice. The collectins, SP-A and SP-D, play distinct roles during bacterial infection of the lung.
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S. Murakami, D. Iwaki, H. Mitsuzawa, H. Sano, H. Takahashi, D. R. Voelker, T. Akino, and Y. Kuroki Surfactant Protein A Inhibits Peptidoglycan-induced Tumor Necrosis Factor-alpha Secretion in U937 Cells and Alveolar Macrophages by Direct Interaction with Toll-like Receptor 2 J. Biol. Chem., February 22, 2002; 277(9): 6830 - 6837. [Abstract] [Full Text] [PDF]
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J. S. Ferguson, D. R. Voelker, J. A. Ufnar, A. J. Dawson, and L. S. Schlesinger Surfactant Protein D Inhibition of Human Macrophage Uptake of Mycobacterium tuberculosis Is Independent of Bacterial Agglutination J. Immunol., February 1, 2002; 168(3): 1309 - 1314. [Abstract] [Full Text] [PDF]
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T. R. Korfhagen Surfactant Protein A (SP-A)-Mediated Bacterial Clearance . SP-A and Cystic Fibrosis Am. J. Respir. Cell Mol. Biol., December 1, 2001; 25(6): 668 - 672. [Full Text] [PDF]
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K. G. Brinker, E. Martin, P. Borron, E. Mostaghel, C. Doyle, C. V. Harding, and J. R. Wright Surfactant protein D enhances bacterial antigen presentation by bone marrow-derived dendritic cells Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1453 - L1463. [Abstract] [Full Text] [PDF]
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W. T. Watford, J. R. Wright, C. G. Hester, H. Jiang, and M. M. Frank Surfactant Protein A Regulates Complement Activation J. Immunol., December 1, 2001; 167(11): 6593 - 6600. [Abstract] [Full Text] [PDF]
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A. M. LeVine, J. A. Whitsett, K. L. Hartshorn, E. C. Crouch, and T. R. Korfhagen Surfactant Protein D Enhances Clearance of Influenza A Virus from the Lung In Vivo J. Immunol., November 15, 2001; 167(10): 5868 - 5873. [Abstract] [Full Text] [PDF]
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J. M. Hickman-Davis, F. C. Fang, C. Nathan, V. L. Shepherd, D. R. Voelker, and J. R. Wright Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions Am J Physiol Lung Cell Mol Physiol, September 1, 2001; 281(3): L517 - L523. [Abstract] [Full Text] [PDF]
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M. Yoshida, T. R. Korfhagen, and J. A. Whitsett Surfactant Protein D Regulates NF-{{kappa}}B and Matrix Metalloproteinase Production in Alveolar Macrophages via Oxidant-Sensitive Pathways J. Immunol., June 15, 2001; 166(12): 7514 - 7519. [Abstract] [Full Text] [PDF]
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J. R. Wright, P. Borron, K. G. Brinker, and R. J. Folz Surfactant Protein A . Regulation of Innate and Adaptive Immune Responses in Lung Inflammation Am. J. Respir. Cell Mol. Biol., May 1, 2001; 24(5): 513 - 517. [Full Text]
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B. C. Trask, M. J. Malone, E. H. Lum, H. G. Welgus, E. C. Crouch, and S. D. Shapiro Induction of Macrophage Matrix Metalloproteinase Biosynthesis by Surfactant Protein D J. Biol. Chem., October 5, 2001; 276(41): 37846 - 37852. [Abstract] [Full Text] [PDF]
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