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RIß Subunit Do Not Impact Its Two Amplification Functions
*
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215; and
Asthma Genetics Group, University of Oxford, Wellcome Trust Center for Human Genetics, Oxford, United Kingdom
Two variants of the ß-chain of the high affinity IgE receptor
Fc
RI, I181L-V183L and E237G, have been found associated with
allergy. We have previously shown that the ß-chain plays at least two
distinct amplifier functions. It amplifies FcRI surface expression
and signaling, resulting in an estimated 12- to 30-fold amplification
of downstream events. To test the hypothesis that the I181L-V183L and
E237G ß variants may be functionally relevant and could directly
contribute to an allergic phenotype, we have evaluated the functional
impact of the ß variants on the two amplifier functions of ß. We
found that these variants have no direct effect on the ß amplifier
functions. However, the possibility remains that these variants are in
linkage disequilibrium with other more relevant polymorphisms or are
affecting unknown ß-chain functions.
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