| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Molecular Immunology, National Institute for Medical Research, London, United Kingdom
In this paper we compare survival characteristics of transgenic and polyclonal CD4 and CD8 T cells. Transgenic CD4 T cells have an intrinsically lower capacity for survival, reflected in their gradual disappearance in thymectomized hosts, their increased sensitivity to apoptosis in vitro, and fewer divisions during homeostatic proliferation upon transfer into syngeneic lymphopenic hosts compared with CD8 T cells. Homeostatic proliferation, however, does not generally result in phenotypic conversion of activation markers unless cognate or cross-reactive Ag is present. T cells from the A18 TCR transgenic strain normally selected into the CD4 lineage are fragile as CD4 T cells, yet display the typical robust survival pattern of CD8 T cells when diverted into the CD8 lineage in a CD4-deficient host. Polyclonal CD4 and CD8 T cells also show distinctive patterns of survival, emphasizing that survival signals are relayed differently in the two lymphocyte subpopulations. However, expression levels of Bcl-2 in either transgenic or polyclonal naive CD4 and CD8 T cells are similar, excluding a role for this molecule as a key factor in differential survival of CD4 vs CD8 T cells.
This article has been cited by other articles:
|
|
 |
|
  M. Ahmed, K. G. Lanzer, E. J. Yager, P. S. Adams, L. L. Johnson, and M. A. Blackman Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice J. Immunol., January 15, 2009; 182(2): 784 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Agenes, J.-P. Dangy, and J. Kirberg T cell receptor contact to restricting MHC molecules is a prerequisite for peripheral interclonal T cell competition J. Exp. Med., November 24, 2008; 205(12): 2735 - 2743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yates, M. Saini, A. Mathiot, and B. Seddon Mathematical Modeling Reveals the Biological Program Regulating Lymphopenia-Induced Proliferation J. Immunol., February 1, 2008; 180(3): 1414 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bourgeois and B. Stockinger CD25+CD4+ Regulatory T Cells and Memory T Cells Prevent Lymphopenia-Induced Proliferation of Naive T Cells in Transient States of Lymphopenia J. Immunol., October 1, 2006; 177(7): 4558 - 4566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-G. Zhang, C. Liu, K. Su, S. Yu, L. Zhang, S. Zhang, J. Wang, X. Cao, W. Grizzle, and R. P. Kimberly A Membrane Form of TNF-{alpha} Presented by Exosomes Delays T Cell Activation-Induced Cell Death. J. Immunol., June 15, 2006; 176(12): 7385 - 7393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. French, C. L. Roark, W. K. Born, and R. L. O'Brien {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells PNAS, October 11, 2005; 102(41): 14741 - 14746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bourgeois, G. Kassiotis, and B. Stockinger A Major Role for Memory CD4 T Cells in the Control of Lymphopenia-Induced Proliferation of Naive CD4 T Cells J. Immunol., May 1, 2005; 174(9): 5316 - 5323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Barthlott, H. Moncrieffe, M. Veldhoen, C. J. Atkins, J. Christensen, A. O'Garra, and B. Stockinger CD25+CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production Int. Immunol., March 1, 2005; 17(3): 279 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Green and D. G. Rowbottom Exercise-induced changes to in vitro T-lymphocyte mitogen responses using CFSE J Appl Physiol, July 1, 2003; 95(1): 57 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Martin, C. Bourgeois, N. Dautigny, and B. Lucas On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells PNAS, May 13, 2003; 100(10): 6021 - 6026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kassiotis, R. Zamoyska, and B. Stockinger Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells J. Exp. Med., April 21, 2003; 197(8): 1007 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Barthlott, G. Kassiotis, and B. Stockinger T Cell Regulation as a Side Effect of Homeostasis and Competition J. Exp. Med., February 17, 2003; 197(4): 451 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. de Jersey, D. Carmignac, T. Barthlott, I. Robinson, and B. Stockinger Activation of CD8 T Cells by Antigen Expressed in the Pituitary Gland J. Immunol., December 15, 2002; 169(12): 6753 - 6759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Seddon and R. Zamoyska TCR and IL-7 Receptor Signals Can Operate Independently or Synergize to Promote Lymphopenia-Induced Expansion of Naive T Cells J. Immunol., October 1, 2002; 169(7): 3752 - 3759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Seddon and R. Zamoyska TCR Signals Mediated by Src Family Kinases Are Essential for the Survival of Naive T Cells J. Immunol., September 15, 2002; 169(6): 2997 - 3005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tanchot, A. Le Campion, B. Martin, S. Leaument, N. Dautigny, and B. Lucas Conversion of Naive T Cells to a Memory-Like Phenotype in Lymphopenic Hosts Is Not Related to a Homeostatic Mechanism That Fills the Peripheral Naive T Cell Pool J. Immunol., May 15, 2002; 168(10): 5042 - 5046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Le Campion, C. Bourgeois, F. Lambolez, B. Martin, S. Leaument, N. Dautigny, C. Tanchot, C. Penit, and B. Lucas Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes PNAS, April 2, 2002; 99(7): 4538 - 4543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Thomas, A. Noble, E. Sawicka, P. W. Askenase, and D. M. Kemeny CD8 T Cells Inhibit IgE Via Dendritic Cell IL-12 Induction That Promotes Th1 T Cell Counter-Regulation J. Immunol., January 1, 2002; 168(1): 216 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ploix, D. Lo, and M. J. Carson A Ligand for the Chemokine Receptor CCR7 Can Influence the Homeostatic Proliferation of CD4 T Cells and Progression of Autoimmunity J. Immunol., December 15, 2001; 167(12): 6724 - 6730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Wedderburn, A. Patel, H. Varsani, and P. Woo Divergence in the degree of clonal expansions in inflammatory T cell subpopulations mirrors HLA-associated risk alleles in genetically and clinically distinct subtypes of childhood arthritis Int. Immunol., December 1, 2001; 13(12): 1541 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Gudmundsdottir and L. A. Turka A Closer Look at Homeostatic Proliferation of CD4+ T Cells: Costimulatory Requirements and Role in Memory Formation J. Immunol., October 1, 2001; 167(7): 3699 - 3707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Seddon, G. Legname, P. Tomlinson, and R. Zamoyska Long-Term Survival But Impaired Homeostatic Proliferation of Naive T Cells in the Absence of p56lck Science, October 6, 2000; 290(5489): 127 - 131. [Abstract] [Full Text]
|
|
|
|
|
|
A. Le Campion, C. Bourgeois, F. Lambolez, B. Martin, S. Leaument, N. Dautigny, C. Tanchot, C. Penit, and B. Lucas Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes PNAS, April 2, 2002; 99(7): 4538 - 4543. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
