| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Max Planck Institut für Immunbiologie, Freiburg, Germany; and
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Cytotoxic T (Tc) cells deficient in perforin lyse Fas-negative targets after lengthy incubation periods. This process is independent of granzymes, and killing occurs via the Fas pathway for the following reasons. Interaction of perforin-deficient Tc cells with Fas-negative targets leads to an up-regulation of Fas that is dependent on Ag recognition, de novo synthesis, and transport of proteins to the target cell surface. Treatment of effectors with brefeldin A, but not with the exocytosis inhibitor concanamycin, inhibited this process. Lysis of targets is inhibited by anti-Fas Abs, soluble mouse Fas-Fc, and the caspase-cascade inhibitor, crm-A. Targets from Fas-mutant lpr mice are refractory to lysis, and Tc cells from mice deficient in Fas- and perforin-mediated lysis do not lyse Fas-negative targets. The possible relevance of this exocytosis-independent cytolytic process in the regulation of T cell activity and control of pathogens is discussed.
This article has been cited by other articles:
|
|
 |
|
  V. Panchanathan, G. Chaudhri, and G. Karupiah Protective Immunity against Secondary Poxvirus Infection Is Dependent on Antibody but Not on CD4 or CD8 T-Cell Function. J. Virol., July 1, 2006; 80(13): 6333 - 6338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Schillaci, M. Salatino, J. Cassataro, C. J. Proietti, G. H. Giambartolomei, M. A. Rivas, R. P. Carnevale, E. H. Charreau, and P. V. Elizalde Immunization with Murine Breast Cancer Cells Treated with Antisense Oligodeoxynucleotides to Type I Insulin-Like Growth Factor Receptor Induced an Antitumoral Effect Mediated by a CD8+ Response Involving Fas/Fas Ligand Cytotoxic Pathway J. Immunol., March 15, 2006; 176(6): 3426 - 3437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rode, S. Balkow, V. Sobek, R. Brehm, P. Martin, A. Kersten, T. Dumrese, T. Stehle, A. Mullbacher, R. Wallich, et al. Perforin and Fas Act Together in the Induction of Apoptosis, and Both Are Critical in the Clearance of Lymphocytic Choriomeningitis Virus Infection J. Virol., November 15, 2004; 78(22): 12395 - 12405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Martin, J. C. Dudda, V. Delattre, E. Bachtanian, C. Leicht, B. Burger, H. U. Weltzien, and J. C. Simon Fas-Mediated Inhibition of CD4+ T Cell Priming Results in Dominance of Type 1 CD8+ T Cells in the Immune Response to the Contact Sensitizer Trinitrophenyl J. Immunol., September 1, 2004; 173(5): 3178 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nikiforow, K. Bottomly, G. Miller, and C. Munz Cytolytic CD4+-T-Cell Clones Reactive to EBNA1 Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation J. Virol., November 15, 2003; 77(22): 12088 - 12104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Sheard, S. Uldrijan, and B. Vojtesek Role of p53 in Regulating Constitutive and X-Radiation-Inducible CD95 Expression and Function in Carcinoma Cells Cancer Res., November 1, 2003; 63(21): 7176 - 7184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Janssens, V. Carlier, B. Wu, L. VanderElst, M. G. Jacquemin, and J.-M. R. Saint-Remy CD4+CD25+ T Cells Lyse Antigen-Presenting B Cells by Fas-Fas Ligand Interaction in an Epitope-Specific Manner J. Immunol., November 1, 2003; 171(9): 4604 - 4612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Schmitz, E. Reali, J. W. Hodge, A. Patel, G. Davis, J. Schlom, and J. W. Greiner Identification of an Interferon-{gamma}-inducible Carcinoembryonic Antigen (CEA) CD8+ T-Cell Epitope, Which Mediates Tumor Killing in CEA Transgenic Mice Cancer Res., September 1, 2002; 62(17): 5058 - 5064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mullbacher, M. Lobigs, R. T. Hla, T. Tran, T. Stehle, and M. M. Simon Antigen-Dependent Release of IFN-{gamma} by Cytotoxic T Cells Up-Regulates Fas on Target Cells and Facilitates Exocytosis-Independent Specific Target Cell Lysis J. Immunol., July 1, 2002; 169(1): 145 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Stewart IV, D. M. Nguyen, G. A. Chen, D. S. Schrump, and S. V. Rusch Induction of apoptosis in malignant pleural mesothelioma cells by activation of the Fas (Apo-1/CD95) death-signal pathway J. Thorac. Cardiovasc. Surg., February 1, 2002; 123(2): 295 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mullbacher and M. Lobigs Creation of Killer Poxvirus Could Have Been Predicted J. Virol., September 15, 2001; 75(18): 8353 - 8355. [Full Text] [PDF]
|
|
|
|
|
|
S. Balkow, A. Kersten, T. T. T. Tran, T. Stehle, P. Grosse, C. Museteanu, O. Utermohlen, H. Pircher, F. von Weizsacker, R. Wallich, et al. Concerted Action of the FasL/Fas and Perforin/Granzyme A and B Pathways Is Mandatory for the Development of Early Viral Hepatitis but Not for Recovery from Viral Infection J. Virol., September 15, 2001; 75(18): 8781 - 8791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Screpanti, R. P. A. Wallin, H.-G. Ljunggren, and A. Grandien A Central Role for Death Receptor-Mediated Apoptosis in the Rejection of Tumors by NK Cells J. Immunol., August 15, 2001; 167(4): 2068 - 2073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhou, T. B. Stuge, N. W. Miller, E. Bengten, J. P. Naftel, J. M. Bernanke, V. G. Chinchar, L. W. Clem, and M. Wilson Heterogeneity of Channel Catfish CTL with Respect to Target Recognition and Cytotoxic Mechanisms Employed J. Immunol., August 1, 2001; 167(3): 1325 - 1332. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
