| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
Previously we have shown that autoimmune diabetes, induced in rats by a protocol of adult thymectomy and split-dose gamma irradiation, can be prevented by the transfer of a subset of CD4+ T cells with a memory phenotype (CD45RC-), as well as by CD4+CD8- thymocytes, from syngeneic donors. Further studies now reveal that in the thymus the regulatory cells are observed in the CD25+ subset of CD4+CD8- cells, whereas transfer of the corresponding CD25- thymocyte subset leads to acceleration of disease onset in prediabetic recipients. However, in the periphery, not all regulatory T cells were found to be CD25+. In thoracic duct lymph, cells that could prevent diabetes were found in both CD25- and CD25+ subsets of CD4+CD45RC- cells. Further, CD25- regulatory T cells were also present within the CD4+CD45RC- cell subset from spleen and lymph nodes, but were effective in preventing diabetes only after the removal of CD25- recent thymic emigrants. Phenotypic analysis of human thymocytes showed the presence of CD25+ cells in the same proportions as in rat thymus. The possible developmental relationship between CD25+ and CD25- regulatory T cells is discussed.
This article has been cited by other articles:
|
|
 |
|
  J. Ji and M. W. Cloyd HIV-1 binding to CD4 on CD4+CD25+ regulatory T cells enhances their suppressive function and induces them to home to, and accumulate in, peripheral and mucosal lymphoid tissues: an additional mechanism of immunosuppression Int. Immunol., March 1, 2009; 21(3): 283 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Han, Q. Guo, M. Zhang, Z. Chen, and X. Cao CD69+CD4+CD25- T Cells, a New Subset of Regulatory T Cells, Suppress T Cell Proliferation through Membrane-Bound TGF-{beta}1 J. Immunol., January 1, 2009; 182(1): 111 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. H. E. Mabarrack, N. L. Turner, and G. Mayrhofer Recent thymic origin, differentiation, and turnover of regulatory T cells J. Leukoc. Biol., November 1, 2008; 84(5): 1287 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Baatar, P. Olkhanud, K. Sumitomo, D. Taub, R. Gress, and A. Biragyn Human Peripheral Blood T Regulatory Cells (Tregs), Functionally Primed CCR4+ Tregs and Unprimed CCR4- Tregs, Regulate Effector T Cells Using FasL J. Immunol., April 15, 2007; 178(8): 4891 - 4900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Couper, D. G. Blount, J. B. de Souza, I. Suffia, Y. Belkaid, and E. M. Riley Incomplete Depletion and Rapid Regeneration of Foxp3+ Regulatory T Cells Following Anti-CD25 Treatment in Malaria-Infected Mice J. Immunol., April 1, 2007; 178(7): 4136 - 4146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kreijveld, H. J. P. M. Koenen, L. B. Hilbrands, H. J. P. van Hooff, and I. Joosten The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+CD25- T cells Blood, January 1, 2007; 109(1): 244 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sharma, A. L. Dominguez, and J. Lustgarten High Accumulation of T Regulatory Cells Prevents the Activation of Immune Responses in Aged Animals J. Immunol., December 15, 2006; 177(12): 8348 - 8355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Hillebrands, B. Whalen, J. T. J. Visser, J. Koning, K. D. Bishop, J. Leif, J. Rozing, J. P. Mordes, D. L. Greiner, and A. A. Rossini A Regulatory CD4+ T Cell Subset in the BB Rat Model of Autoimmune Diabetes Expresses Neither CD25 Nor Foxp3 J. Immunol., December 1, 2006; 177(11): 7820 - 7832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Lawson, A. K. Brown, V. Bejarano, S. H. Douglas, C. H. Burgoyne, A. S. Greenstein, A. W. Boylston, P. Emery, F. Ponchel, and J. D. Isaacs Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral blood Rheumatology, October 1, 2006; 45(10): 1210 - 1217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Vojdani and J. Erde Regulatory T Cells, a Potent Immunoregulatory Target for CAM Researchers: Modulating Tumor Immunity, Autoimmunity and Alloreactive Immunity (III) Evid. Based Complement. Altern. Med., September 1, 2006; 3(3): 309 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Scalapino, Q. Tang, J. A. Bluestone, M. L. Bonyhadi, and D. I. Daikh Suppression of Disease in New Zealand Black/New Zealand White Lupus-Prone Mice by Adoptive Transfer of Ex Vivo Expanded Regulatory T Cells J. Immunol., August 1, 2006; 177(3): 1451 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Lim, H. E. Broxmeyer, and C. H. Kim Regulation of Trafficking Receptor Expression in Human Forkhead Box P3+ Regulatory T Cells J. Immunol., July 15, 2006; 177(2): 840 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ono, J. Shimizu, Y. Miyachi, and S. Sakaguchi Control of Autoimmune Myocarditis and Multiorgan Inflammation by Glucocorticoid-Induced TNF Receptor Family-Related Proteinhigh, Foxp3-Expressing CD25+ and CD25- Regulatory T Cells. J. Immunol., April 15, 2006; 176(8): 4748 - 4756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. C. Rogner, F. Lepault, M.-C. Gagnerault, D. Vallois, J. Morin, P. Avner, and C. Boitard The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4+CD25+ Regulatory T-Cells Diabetes, January 1, 2006; 55(1): 186 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Maker, P. Attia, and S. A. Rosenberg Analysis of the Cellular Mechanism of Antitumor Responses and Autoimmunity in Patients Treated with CTLA-4 Blockade J. Immunol., December 1, 2005; 175(11): 7746 - 7754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Stephens, D. Gray, and S. M. Anderton CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity PNAS, November 29, 2005; 102(48): 17418 - 17423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U G Strauch, F Obermeier, N Grunwald, S Gurster, N Dunger, M Schultz, D P Griese, M Mahler, J Scholmerich, and H C Rath Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis Gut, November 1, 2005; 54(11): 1546 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Gillan and E. Devaney Regulatory T Cells Modulate Th2 Responses Induced by Brugia pahangi Third-Stage Larvae Infect. Immun., July 1, 2005; 73(7): 4034 - 4042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. P. M. Koenen, E. Fasse, and I. Joosten CD27/CFSE-Based Ex Vivo Selection of Highly Suppressive Alloantigen-Specific Human Regulatory T Cells J. Immunol., June 15, 2005; 174(12): 7573 - 7583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. You, M. Belghith, S. Cobbold, M.-A. Alyanakian, C. Gouarin, S. Barriot, C. Garcia, H. Waldmann, J.-F. Bach, and L. Chatenoud Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells Diabetes, May 1, 2005; 54(5): 1415 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Y. Wan and R. A. Flavell Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter PNAS, April 5, 2005; 102(14): 5126 - 5131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Marie, J. J. Letterio, M. Gavin, and A. Y. Rudensky TGF-{beta}1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells J. Exp. Med., April 4, 2005; 201(7): 1061 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lundsgaard, T. L. Holm, L. Hornum, and H. Markholst In Vivo Control of Diabetogenic T-Cells by Regulatory CD4+CD25+ T-Cells Expressing Foxp3 Diabetes, April 1, 2005; 54(4): 1040 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Poussier, T. Ning, T. Murphy, D. Dabrowski, and S. Ramanathan Impaired Post-Thymic Development of Regulatory CD4+25+ T Cells Contributes to Diabetes Pathogenesis in BB Rats J. Immunol., April 1, 2005; 174(7): 4081 - 4089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shimizu, R. Iida, Y. Sato, E. Moriizumi, A. Nishikawa, and Y. Ishida Cross-Linking of CD45 on Suppressive/Regulatory T Cells Leads to the Abrogation of Their Suppressive Activity In Vitro J. Immunol., April 1, 2005; 174(7): 4090 - 4097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Eggena, B. Barugahare, N. Jones, M. Okello, S. Mutalya, C. Kityo, P. Mugyenyi, and H. Cao Depletion of Regulatory T Cells in HIV Infection Is Associated with Immune Activation J. Immunol., April 1, 2005; 174(7): 4407 - 4414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bushell, E. Jones, A. Gallimore, and K. Wood The Generation of CD25+CD4+ Regulatory T Cells That Prevent Allograft Rejection Does Not Compromise Immunity to a Viral Pathogen J. Immunol., March 15, 2005; 174(6): 3290 - 3297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Rao, A. L. Petrone, and P. D. Ponath Differentiation and Expansion of T Cells with Regulatory Function from Human Peripheral Lymphocytes by Stimulation in the Presence of TGF-{beta} J. Immunol., February 1, 2005; 174(3): 1446 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Curotto de Lafaille, A. C. Lino, N. Kutchukhidze, and J. J. Lafaille CD25- T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion J. Immunol., December 15, 2004; 173(12): 7259 - 7268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Xystrakis, A. S. Dejean, I. Bernard, P. Druet, R. Liblau, D. Gonzalez-Dunia, and A. Saoudi Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation Blood, November 15, 2004; 104(10): 3294 - 3301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. Dujardin, O. Burlen-Defranoux, L. Boucontet, P. Vieira, A. Cumano, and A. Bandeira Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells PNAS, October 5, 2004; 101(40): 14473 - 14478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Makita, T. Kanai, S. Oshima, K. Uraushihara, T. Totsuka, T. Sawada, T. Nakamura, K. Koganei, T. Fukushima, and M. Watanabe CD4+CD25bright T Cells in Human Intestinal Lamina Propria as Regulatory Cells J. Immunol., September 1, 2004; 173(5): 3119 - 3130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Nishimura, T. Sakihama, R. Setoguchi, K. Tanaka, and S. Sakaguchi Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells Int. Immunol., August 1, 2004; 16(8): 1189 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Lerman, J. Larkin III, C. Cozzo, M. S. Jordan, and A. J. Caton CD4+ CD25+ Regulatory T Cell Repertoire Formation in Response to Varying Expression of a neo-Self-Antigen J. Immunol., July 1, 2004; 173(1): 236 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Apostolou and H. von Boehmer In Vivo Instruction of Suppressor Commitment in Naive T Cells J. Exp. Med., May 17, 2004; 199(10): 1401 - 1408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. de Kleer, L. R. Wedderburn, L. S. Taams, A. Patel, H. Varsani, M. Klein, W. de Jager, G. Pugayung, F. Giannoni, G. Rijkers, et al. CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis J. Immunol., May 15, 2004; 172(10): 6435 - 6443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Vahlenkamp, M. B. Tompkins, and W. A. F. Tompkins Feline Immunodeficiency Virus Infection Phenotypically and Functionally Activates Immunosuppressive CD4+CD25+ T Regulatory Cells J. Immunol., April 15, 2004; 172(8): 4752 - 4761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Beilharz, L. M. Sammels, A. Paun, K. Shaw, P. van Eeden, M. W. Watson, and M. L. Ashdown Timed Ablation of Regulatory CD4+ T Cells Can Prevent Murine AIDS Progression J. Immunol., April 15, 2004; 172(8): 4917 - 4925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Nelson IL-2, Regulatory T Cells, and Tolerance J. Immunol., April 1, 2004; 172(7): 3983 - 3988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kajiura, S. Sun, T. Nomura, K. Izumi, T. Ueno, Y. Bando, N. Kuroda, H. Han, Y. Li, A. Matsushima, et al. NF-{kappa}B-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner J. Immunol., February 15, 2004; 172(4): 2067 - 2075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Stephens, A. N. Barclay, and D. Mason Phenotypic characterization of regulatory CD4+CD25+ T cells in rats Int. Immunol., February 1, 2004; 16(2): 365 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jonuleit and E. Schmitt The Regulatory T Cell Family: Distinct Subsets and their Interrelations J. Immunol., December 15, 2003; 171(12): 6323 - 6327. [Full Text] [PDF]
|
|
|
|
|
|
E. S. Yvon, S. Vigouroux, R. F. Rousseau, E. Biagi, P. Amrolia, G. Dotti, H.-J. Wagner, and M. K. Brenner Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells Blood, November 15, 2003; 102(10): 3815 - 3821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Anastasi, A. F. Campese, D. Bellavia, A. Bulotta, A. Balestri, M. Pascucci, S. Checquolo, R. Gradini, U. Lendahl, L. Frati, et al. Expression of Activated Notch3 in Transgenic Mice Enhances Generation of T Regulatory Cells and Protects against Experimental Autoimmune Diabetes J. Immunol., November 1, 2003; 171(9): 4504 - 4511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Janssens, V. Carlier, B. Wu, L. VanderElst, M. G. Jacquemin, and J.-M. R. Saint-Remy CD4+CD25+ T Cells Lyse Antigen-Presenting B Cells by Fas-Fas Ligand Interaction in an Epitope-Specific Manner J. Immunol., November 1, 2003; 171(9): 4604 - 4612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Dubois, L. Chapat, A. Goubier, M. Papiernik, J.-F. Nicolas, and D. Kaiserlian Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation Blood, November 1, 2003; 102(9): 3295 - 3301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gregori, N. Giarratana, S. Smiroldo, and L. Adorini Dynamics of Pathogenic and Suppressor T Cells in Autoimmune Diabetes Development J. Immunol., October 15, 2003; 171(8): 4040 - 4047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Feunou, L. Poulin, C. Habran, A. Le Moine, M. Goldman, and M. Y. Braun CD4+CD25+ and CD4+CD25- T Cells Act Respectively as Inducer and Effector T Suppressor Cells in Superantigen-Induced Tolerance J. Immunol., October 1, 2003; 171(7): 3475 - 3484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. von Boehmer Dynamics of Suppressor T Cells: In Vivo Veritas J. Exp. Med., September 15, 2003; 198(6): 845 - 849. [Full Text] [PDF]
|
|
|
|
|
|
T. Mizobuchi, K. Yasufuku, Y. Zheng, M. A. Haque, K. M. Heidler, K. Woods, G. N. Smith Jr., O. W. Cummings, T. Fujisawa, J. S. Blum, et al. Differential Expression of Smad7 Transcripts Identifies the CD4+CD45RChigh Regulatory T Cells That Mediate Type V Collagen-Induced Tolerance to Lung Allografts J. Immunol., August 1, 2003; 171(3): 1140 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Klein, K. Khazaie, and H. von Boehmer In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro PNAS, July 22, 2003; 100(15): 8886 - 8891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Uraushihara, T. Kanai, K. Ko, T. Totsuka, S. Makita, R. Iiyama, T. Nakamura, and M. Watanabe Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25- CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene+ Regulatory T Cells J. Immunol., July 15, 2003; 171(2): 708 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Asseman, S. Read, and F. Powrie Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and IL-10 J. Immunol., July 15, 2003; 171(2): 971 - 978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Marshall, M. A. Vickers, and R. N. Barker Regulatory T Cells Secreting IL-10 Dominate the Immune Response to EBV Latent Membrane Protein 1 J. Immunol., June 15, 2003; 170(12): 6183 - 6189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. W. J. Unger, W. Jansen, D. A. W. Wolvers, A. G. S. van Halteren, G. Kraal, and J. N. Samsom Nasal tolerance induces antigen-specific CD4+CD25- regulatory T cells that can transfer their regulatory capacity to naive CD4+ T cells Int. Immunol., June 1, 2003; 15(6): 731 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Paas-Rozner, M. Sela, and E. Mozes A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25- and CTLA-4-expressing CD4+ T cells PNAS, May 27, 2003; 100(11): 6676 - 6681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Grundstrom, L. Cederbom, A. Sundstedt, P. Scheipers, and F. Ivars Superantigen-Induced Regulatory T Cells Display Different Suppressive Functions in the Presence or Absence of Natural CD4+CD25+ Regulatory T Cells In Vivo J. Immunol., May 15, 2003; 170(10): 5008 - 5017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oida, X. Zhang, M. Goto, S. Hachimura, M. Totsuka, S. Kaminogawa, and H. L. Weiner CD4+CD25- T Cells That Express Latency-Associated Peptide on the Surface Suppress CD4+CD45RBhigh-Induced Colitis by a TGF-{beta}-Dependent Mechanism J. Immunol., March 1, 2003; 170(5): 2516 - 2522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Barthlott, G. Kassiotis, and B. Stockinger T Cell Regulation as a Side Effect of Homeostasis and Competition J. Exp. Med., February 17, 2003; 197(4): 451 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shimizu and E. Moriizumi CD4+CD25- T Cells in Aged Mice Are Hyporesponsive and Exhibit Suppressive Activity J. Immunol., February 15, 2003; 170(4): 1675 - 1682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hori, T. Nomura, and S. Sakaguchi Control of Regulatory T Cell Development by the Transcription Factor Foxp3 Science, February 14, 2003; 299(5609): 1057 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Maloy, L. Salaun, R. Cahill, G. Dougan, N. J. Saunders, and F. Powrie CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms J. Exp. Med., January 6, 2003; 197(1): 111 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Zheng, J. D. Gray, K. Ohtsuka, S. Yamagiwa, and D. A. Horwitz Generation Ex Vivo of TGF-{beta}-Producing Regulatory T Cells from CD4+CD25- Precursors J. Immunol., October 15, 2002; 169(8): 4183 - 4189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schwartz and J. Kipnis Multiple Sclerosis as a By-Product of the Failure to Sustain Protective Autoimmunity: A Paradigm Shift Neuroscientist, October 1, 2002; 8(5): 405 - 413. [Abstract] [PDF]
|
|
|
|
|
|
J. Lehmann, J. Huehn, M. de la Rosa, F. Maszyna, U. Kretschmer, V. Krenn, M. Brunner, A. Scheffold, and A. Hamann Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells PNAS, October 1, 2002; 99(20): 13031 - 13036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Szanya, J. Ermann, C. Taylor, C. Holness, and C. G. Fathman The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR7 J. Immunol., September 1, 2002; 169(5): 2461 - 2465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Kullberg, D. Jankovic, P. L. Gorelick, P. Caspar, J. J. Letterio, A. W. Cheever, and A. Sher Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus-induced Colitis J. Exp. Med., August 19, 2002; 196(4): 505 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Hoffmann, J. Ermann, M. Edinger, C. G. Fathman, and S. Strober Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation J. Exp. Med., August 5, 2002; 196(3): 389 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Cohen, A. Trenado, D. Vasey, D. Klatzmann, and B. L. Salomon CD4+CD25+ Immunoregulatory T Cells: New Therapeutics for Graft-Versus-Host Disease J. Exp. Med., August 5, 2002; 196(3): 401 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, A. Sakamoto, J. Bender, J. Kappler, and P. Marrack CD25+CD4+ T cells contribute to the control of memory CD8+ T cells PNAS, June 25, 2002; 99(13): 8832 - 8837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hori, M. Haury, A. Coutinho, and J. Demengeot Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice PNAS, June 11, 2002; 99(12): 8213 - 8218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Graca, S. Thompson, C.-Y. Lin, E. Adams, S. P. Cobbold, and H. Waldmann Both CD4+CD25+ and CD4+CD25- Regulatory Cells Mediate Dominant Transplantation Tolerance J. Immunol., June 1, 2002; 168(11): 5558 - 5565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Jimenez, R. Sacedon, A. Vicente, C. Hernandez-Lopez, A. G. Zapata, and A. Varas Rat Peripheral CD4+CD8+ T Lymphocytes Are Partially Immunocompetent Thymus-Derived Cells That Undergo Post-Thymic Maturation to Become Functionally Mature CD4+ T Lymphocytes J. Immunol., May 15, 2002; 168(10): 5005 - 5013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Chiffoleau, G. Beriou, P. Dutartre, C. Usal, J.-P. Soulillou, and M. C. Cuturi Role for Thymic and Splenic Regulatory CD4+ T Cells Induced by Donor Dendritic Cells in Allograft Tolerance by LF15-0195 Treatment J. Immunol., May 15, 2002; 168(10): 5058 - 5069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gregori, N. Giarratana, S. Smiroldo, M. Uskokovic, and L. Adorini A 1{alpha},25-Dihydroxyvitamin D3 Analog Enhances Regulatory T-Cells and Arrests Autoimmune Diabetes in NOD Mice Diabetes, May 1, 2002; 51(5): 1367 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. I. Kingsley, M. Karim, A. R. Bushell, and K. J. Wood CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses J. Immunol., February 1, 2002; 168(3): 1080 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Phillips, N. M. Parish, M. Drage, and A. Cooke Cutting Edge: Interactions Through the IL-10 Receptor Regulate Autoimmune Diabetes J. Immunol., December 1, 2001; 167(11): 6087 - 6091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. C. de Lafaille, S. Muriglan, M.-J. Sunshine, Y. Lei, N. Kutchukhidze, G. C. Furtado, A. K. Wensky, D. Olivares-Villagomez, and J. J. Lafaille Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes"" J. Exp. Med., November 5, 2001; 194(9): 1349 - 1360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, L. Izikson, L. Liu, and H. L. Weiner Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration J. Immunol., October 15, 2001; 167(8): 4245 - 4253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P.M. Sutmuller, L. M. van Duivenvoorde, A. van Elsas, T. N.M. Schumacher, M. E. Wildenberg, J. P. Allison, R. E.M. Toes, R. Offringa, and C. J.M. Melief Synergism of Cytotoxic T Lymphocyte-associated Antigen 4 Blockade and Depletion of CD25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses J. Exp. Med., September 17, 2001; 194(6): 823 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Baecher-Allan, J. A. Brown, G. J. Freeman, and D. A. Hafler CD4+CD25high Regulatory Cells in Human Peripheral Blood J. Immunol., August 1, 2001; 167(3): 1245 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-D. Shi, M. Flodstrom, B. Balasa, S. H. Kim, K. Van Gunst, J. L. Strominger, S. B. Wilson, and N. Sarvetnick Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse PNAS, June 5, 2001; 98(12): 6777 - 6782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Shevach Certified Professionals: CD4+CD25+ Suppressor T Cells J. Exp. Med., June 4, 2001; 193(11): F41 - F46. [Full Text] [PDF]
|
|
|
|
|
|
O. Annacker, R. Pimenta-Araujo, O. Burlen-Defranoux, T. C. Barbosa, A. Cumano, and A. Bandeira CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10 J. Immunol., March 1, 2001; 166(5): 3008 - 3018. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
