|
|
||||||||






*
Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan;
Department of Ophthalmology, School of Medicine, Hokkaido University, Sapporo, Japan; and
Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Japan
We have defined a peptide K2 (ADKDVVVLTSSRTGGV) that corresponds to
residues 201216 of bovine interphotoreceptor retinoid-binding protein
and induces experimental autoimmune uveoretinitis
(EAU)4 in
H-2Ak-carrying mice (H-2Ak mice). In this
study, we attempted to ameliorate EAU in the H-2Ak mice
without nonspecific suppression of T cell responses. Preceding s.c.
administration of liposomes including K2 (liposomal K2) specifically
inhibited subsequent generation of T cell response to K2. The same
result was obtained with a combination of OVA323339
peptide and the OVA-specific TCR-transgenic T cells. It was suggested
that the inhibition was mainly attributed to peripheral anergy
induction of T cells specific for the peptide Ag, although specific
cell death might also be involved in the inhibition. Pretreatment with
liposomal K2 also considerably abolished IFN-
production but not
IL-4 production. The specific inhibitory effect of the pretreatment
with liposomal peptide was augmented by a simultaneous administration
of anti-CD40 ligand (anti-CD40L) mAb. Moreover, it was shown
that the pretreatment with liposomal K2 reduced both the incidence and
severity of the subsequent K2-induced EAU, and the simultaneous
administration of anti-CD40L mAb augmented this preventive effect
by liposomal K2. Our findings demonstrate that the s.c. administration
of liposomal pathogenic peptide and anti-CD40L mAb can be applied
to preventing autoimmune diseases without detrimental nonspecific
suppression of T cell responses.
This article has been cited by other articles:
![]() |
K. R. Mott, A. A. Chentoufi, D. Carpenter, L. BenMohamed, S. L. Wechsler, and H. Ghiasi The Role of a Glycoprotein K (gK) CD8+ T-Cell Epitope of Herpes Simplex Virus on Virus Replication and Pathogenicity Invest. Ophthalmol. Vis. Sci., June 1, 2009; 50(6): 2903 - 2912. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Usui, M. Takeuchi, T. Hattori, Y. Okunuki, K. Nagasawa, T. Kezuka, K. Okumura, H. Yagita, H. Akiba, and H. Goto Suppression of Experimental Autoimmune Uveoretinitis by Regulatory Dendritic Cells in Mice Arch Ophthalmol, April 1, 2009; 127(4): 514 - 519. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-A. C. Portillo, J. Van Grol, L. Zheng, G. Okenka, K. Gentil, A. Garland, E. C. Carlson, T. S. Kern, and C. S. Subauste CD40 Mediates Retinal Inflammation and Neurovascular Degeneration J. Immunol., December 15, 2008; 181(12): 8719 - 8726. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Kitamura, K. Iwabuchi, N. Kitaichi, S. Kon, H. Kitamei, K. Namba, K. Yoshida, D. T. Denhardt, S. R. Rittling, S. Ohno, et al. Osteopontin Aggravates Experimental Autoimmune Uveoretinitis in Mice J. Immunol., May 15, 2007; 178(10): 6567 - 6572. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Kitamei, K. Iwabuchi, K. Namba, K. Yoshida, Y. Yanagawa, N. Kitaichi, M. Kitamura, S. Ohno, and K. Onoe Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor-{kappa}B (NF-{kappa}B), pyrrolidine dithiocarbamate J. Leukoc. Biol., June 1, 2006; 79(6): 1193 - 1201. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Hashida, N. Ohguro, K. Nakai, M. Kobashi-Hashida, S.-i. Hashimoto, K. Matsushima, and Y. Tano Microarray Analysis of Cytokine and Chemokine Gene Expression after Prednisolone Treatment in Murine Experimental Autoimmune Uveoretinitis Invest. Ophthalmol. Vis. Sci., November 1, 2005; 46(11): 4224 - 4234. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Kitaichi, S. Kotake, T. Morohashi, K. Onoe, S. Ohno, and A. W. Taylor Diminution of experimental autoimmune uveoretinitis (EAU) in mice depleted of NK cells J. Leukoc. Biol., December 1, 2002; 72(6): 1117 - 1121. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Stienekemeier, K. Falk, O. Rotzschke, A. Weishaupt, C. Schneider, K. V. Toyka, R. Gold, and J. L. Strominger Vaccination, prevention, and treatment of experimental autoimmune neuritis (EAN) by an oligomerized T cell epitope PNAS, November 20, 2001; 98(24): 13872 - 13877. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |