| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of
*
Urology and
Internal Medicine, University of Iowa, Iowa City, IA 52242
TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily of cytokines that induces apoptosis in a variety of cancer cells. The results presented in this study demonstrate that introduction of the human TRAIL gene into TRAIL-sensitive tumor cells using an adenoviral vector leads to the rapid production and expression of TRAIL protein, and subsequent death of the tumor cells. Tumor cell death was mediated by an apoptotic mechanism, as evidenced by the activation of caspase-8, cleavage of poly(ADP-ribose) polymerase, binding of annexin V, and inhibition by caspase inhibitor zVAD-fmk. These results define a novel method of using TRAIL as an antitumor therapeutic, and suggest the potential use for an adenovirus-encoding TRAIL as a method of gene therapy for numerous cancer types in vivo.
This article has been cited by other articles:
|
|
 |
|
  L. S. Sasportas, R. Kasmieh, H. Wakimoto, S. Hingtgen, J. A. J. M. van de Water, G. Mohapatra, J. L. Figueiredo, R. L. Martuza, R. Weissleder, and K. Shah Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy PNAS, March 24, 2009; 106(12): 4822 - 4827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hingtgen, X. Ren, E. Terwilliger, M. Classon, R. Weissleder, and K. Shah Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide Mol. Cancer Ther., November 1, 2008; 7(11): 3575 - 3585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. VanOosten and T. S. Griffith Activation of Tumor-Specific CD8+ T Cells after Intratumoral Ad5-TRAIL/CpG Oligodeoxynucleotide Combination Therapy Cancer Res., December 15, 2007; 67(24): 11980 - 11990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Corsten, R. Miranda, R. Kasmieh, A. M. Krichevsky, R. Weissleder, and K. Shah MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell Delivered S-TRAIL in Human Gliomas Cancer Res., October 1, 2007; 67(19): 8994 - 9000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lin, W. Wei, J. Zhang, S. Liu, Y. Liu, and D. Zheng Formyl peptide receptor-like 1 mediated endogenous TRAIL gene expression with tumoricidal activity Mol. Cancer Ther., October 1, 2007; 6(10): 2618 - 2625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Terzioglu, A. Bisgin, A. D. Sanlioglu, M. Ulker, V. Yazisiz, S. Tuzuner, and S. Sanlioglu Concurrent gene therapy strategies effectively destroy synoviocytes of patients with rheumatoid arthritis Rheumatology, May 1, 2007; 46(5): 783 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Carlo-Stella, C. Lavazza, A. Locatelli, L. Vigano, A. M. Gianni, and L. Gianni Targeting TRAIL Agonistic Receptors for Cancer Therapy Clin. Cancer Res., April 15, 2007; 13(8): 2313 - 2317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Miller-Jensen, K. A. Janes, Y.-L. Wong, L. G. Griffith, and D. A. Lauffenburger Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor-necrosis-factor-induced apoptosis J. Cell Sci., September 15, 2006; 119(18): 3788 - 3798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Yun, M.-H. Kweon, H. Kwon, J.-K. Hwang, and H. Mukhtar Induction of apoptosis and cell cycle arrest by a chalcone panduratin A isolated from Kaempferia pandurata in androgen-independent human prostate cancer cells PC3 and DU145 Carcinogenesis, July 1, 2006; 27(7): 1454 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Earel Jr., R. L. VanOosten, and T. S. Griffith Histone Deacetylase Inhibitors Modulate the Sensitivity of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Resistant Bladder Tumor Cells Cancer Res., January 1, 2006; 66(1): 499 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Kemp, A. T. Ludwig, J. K. Earel, J. M. Moore, R. L. VanOosten, B. Moses, K. Leidal, W. M. Nauseef, and T. S. Griffith Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/Apo-2L Blood, November 15, 2005; 106(10): 3474 - 3482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, R. M. Cheung, R. Komaki, B. Fang, and J. Y. Chang Radiotherapy Sensitization by Tumor-Specific TRAIL Gene Targeting Improves Survival of Mice Bearing Human Non-Small Cell Lung Cancer Clin. Cancer Res., September 15, 2005; 11(18): 6657 - 6668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shi, D. Zheng, Y. Liu, M. H. Sham, P. Tam, F. Farzaneh, and R. Xu Overexpression of Soluble TRAIL Induces Apoptosis in Human Lung Adenocarcinoma and Inhibits Growth of Tumor Xenografts in Nude Mice Cancer Res., March 1, 2005; 65(5): 1687 - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Ludwig, J. M. Moore, Y. Luo, X. Chen, N. A. Saltsgaver, M. A. O'Donnell, and T. S. Griffith Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand: A Novel Mechanism for Bacillus Calmette-Guerin-Induced Antitumor Activity Cancer Res., May 15, 2004; 64(10): 3386 - 3390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jacob, J. Davis, H. Zhu, L. Zhang, F. Teraishi, S. Wu, F. C. Marini III, and B. Fang Suppressing Orthotopic Pancreatic Tumor Growth with a Fiber-Modified Adenovector Expressing the TRAIL Gene from the Human Telomerase Reverse Transcriptase Promoter Clin. Cancer Res., May 15, 2004; 10(10): 3535 - 3541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Armeanu, U. M. Lauer, I. Smirnow, M. Schenk, T. S. Weiss, M. Gregor, and M. Bitzer Adenoviral Gene Transfer of Tumor Necrosis Factor-related Apoptosis-Inducing Ligand Overcomes an Impaired Response of Hepatoma Cells but Causes Severe Apoptosis in Primary Human Hepatocytes Cancer Res., May 15, 2003; 63(10): 2369 - 2372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Taghiyev, N. V. Guseva, H. Harada, C. M. Knudson, O. W. Rokhlin, and M. B. Cohen Overexpression of BAD Potentiates Sensitivity to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Treatment in the Prostatic Carcinoma Cell Line LNCaP Mol. Cancer Res., May 1, 2003; 1(7): 500 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ehtesham, P. Kabos, M. A. R. Gutierrez, N. H. C. Chung, T. S. Griffith, K. L. Black, and J. S. Yu Induction of Glioblastoma Apoptosis Using Neural Stem Cell-mediated Delivery of Tumor Necrosis Factor-related Apoptosis-inducing Ligand Cancer Res., December 15, 2002; 62(24): 7170 - 7174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Wang, X. Wang, A. Hernandez, M. R. Hellmich, Z. Gatalica, and B. M. Evers Regulation of TRAIL Expression by the Phosphatidylinositol 3-Kinase/Akt/GSK-3 Pathway in Human Colon Cancer Cells J. Biol. Chem., September 20, 2002; 277(39): 36602 - 36610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lin, J. Gu, L. Zhang, X. Huang, L. C. Stephens, S. A. Curley, and B. Fang Targeted Expression of Green Fluorescent Protein/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Fusion Protein from Human Telomerase Reverse Transcriptase Promoter Elicits Antitumor Activity without Toxic Effects on Primary Human Hepatocytes Cancer Res., July 1, 2002; 62(13): 3620 - 3625. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
