| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of
*
Medical Biochemistry and
Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka, Japan
IL-13 is a multifunctional lymphokine sharing a number of
biological properties with IL-4. We previously observed that IL-4 shows
angiogenic activities in vitro as well as in vivo. In this study we
examined the effect of IL-13 on angiogenesis in vitro and in vivo and
also the underlying mechanisms. Human IL-13 significantly stimulated
the formation of tube-like structures in collagen gels by human
microvascular endothelial cells and bovine aortic endothelial cells by
about 3-fold over the controls in the absence of the cytokines.
Administration of murine IL-13 led to neovascularization when implanted
in the rat cornea. Coadministration of neutralizing mAb to the IL-4R
inhibited both tubular morphogenesis in vitro and activation of STAT6
induced by IL-4 or IL-13. Both IL-4 and IL-13 markedly increased mRNA
levels of VCAM-1 in vascular endothelial cells, and the production of
the soluble form of VCAM-1 was also stimulated in response to IL-4 or
IL-13. Administration of anti-VCAM-1 Ab in vitro blocked tubular
morphogenesis induced by IL-4 and IL-13. Angiogenesis induced in vivo
in rat cornea by IL-4 and IL-13 was also inhibited by Ab against the
rat 
4 integrin subunit. These findings suggest that
angiogenesis dependent on IL-4 and IL-13 is mainly mediated through a
soluble VCAM-1/4 integrin
pathway.
This article has been cited by other articles:
|
|
 |
|
  C. Kadoch, E. B. Dinca, R. Voicu, L. Chen, D. Nguyen, S. Parikh, J. Karrim, M. A. Shuman, C. A. Lowell, P. A. Treseler, et al. Pathologic Correlates of Primary Central Nervous System Lymphoma Defined in an Orthotopic Xenograft Model Clin. Cancer Res., March 15, 2009; 15(6): 1989 - 1997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Frisbee, J. B. Samora, J. Peterson, and R. Bryner Exercise training blunts microvascular rarefaction in the metabolic syndrome Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2483 - H2492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Rubenstein, J. Fridlyand, A. Shen, K. Aldape, D. Ginzinger, T. Batchelor, P. Treseler, M. Berger, M. McDermott, M. Prados, et al. Gene expression and angiotropism in primary CNS lymphoma Blood, May 1, 2006; 107(9): 3716 - 3723. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ohtsuka, K. Inoue, Y. Hara, N. Morioka, K. Ohshima, J. Suzuki, A. Ogimoto, Y. Shigematsu, and J. Higaki Serum markers of angiogenesis and myocardial ultrasonic tissue characterization in patients with dilated cardiomyopathy Eur J Heart Fail, June 1, 2005; 7(4): 689 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-i. Fukushi, I. T. Makagiansar, and W. B. Stallcup NG2 Proteoglycan Promotes Endothelial Cell Motility and Angiogenesis via Engagement of Galectin-3 and {alpha}3{beta}1 Integrin Mol. Biol. Cell, August 1, 2004; 15(8): 3580 - 3590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Calzada, L. Zhou, J. M. Sipes, J. Zhang, H. C. Krutzsch, M. L. Iruela-Arispe, D. S. Annis, D. F. Mosher, and D. D. Roberts {alpha}4{beta}1 Integrin Mediates Selective Endothelial Cell Responses to Thrombospondins 1 and 2 In Vitro and Modulates Angiogenesis In Vivo Circ. Res., March 5, 2004; 94(4): 462 - 470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Chung, B. Y. Kang, and T. S. Kim Inhibition of Interleukin-4 Production in CD4+ T Cells by Peroxisome Proliferator-Activated Receptor-{gamma} (PPAR-{gamma}) Ligands: Involvement of Physical Association between PPAR-{gamma} and the Nuclear Factor of Activated T Cells Transcription Factor Mol. Pharmacol., November 1, 2003; 64(5): 1169 - 1179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nakao, T. Kuwano, T. Ishibashi, M. Kuwano, and M. Ono Synergistic Effect of TNF-{alpha} in Soluble VCAM-1-Induced Angiogenesis Through {alpha}4 Integrins J. Immunol., June 1, 2003; 170(11): 5704 - 5711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Surquin, A. Le Moine, V. Flamand, N. Nagy, K. Rombaut, F.-X. Demoor, P. Stordeur, I. Salmon, J.-C. Guery, M. Goldman, et al. Skin Graft Rejection Elicited by {beta}2-Microglobulin as a Minor Transplantation Antigen Involves Multiple Effector Pathways: Role of Fas-Fas Ligand Interactions and Th2-Dependent Graft Eosinophil Infiltrates J. Immunol., July 1, 2002; 169(1): 500 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hirata, S.-i. Ogawa, T. Kometani, T. Kuwano, S. Naito, M. Kuwano, and M. Ono ZD1839 (Iressa) Induces Antiangiogenic Effects through Inhibition of Epidermal Growth Factor Receptor Tyrosine Kinase Cancer Res., May 1, 2002; 62(9): 2554 - 2560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Uchimiya, T. Furukawa, M. Okamoto, Y. Nakajima, S. Matsushita, R. Ikeda, T. Gotanda, M. Haraguchi, T. Sumizawa, M. Ono, et al. Suppression of Thymidine Phosphorylase-mediated Angiogenesis and Tumor Growth by 2-Deoxy-L-ribose Cancer Res., May 1, 2002; 62(10): 2834 - 2839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tedgui and Z. Mallat Anti-Inflammatory Mechanisms in the Vascular Wall Circ. Res., May 11, 2001; 88(9): 877 - 887. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
