| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-T Cells Are Critical for Survival and Early Proinflammatory Cytokine Gene Expression During Murine Klebsiella Pneumonia1
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109
Although cells of the innate inflammatory response, such as
macrophages and neutrophils, have been extensively studied in the arena
of Gram-negative bacterial pneumonia, a role for T cells remains
unknown. To study the role of specific T cell populations in bacterial
pneumonia, mice deleted of their TCR ß- and/or 
-chain were
intratracheally inoculated with Klebsiella pneumoniae.
T cell knockout mice displayed increased mortality at both early
and late time points. In contrast, mice specifically lacking only
ß-T cells were no more susceptible than wild-type mice. Pulmonary
bacterial clearance in -T cell knockout mice was unimpaired.
Interestingly, these mice displayed increased peripheral blood
dissemination. Rapid up-regulation of IFN- and TNF- gene
expression, critical during bacterial infections, was markedly impaired
in lung and liver tissue from -T cell-deficient mice 24 h
postinfection. The increased peripheral blood bacterial dissemination
correlated with impaired hepatic bacterial clearance following
pulmonary infection and increased hepatic injury as measured by plasma
aspartate aminotransferase activity. Combined, these data suggest that
mice lacking -T cells have an impaired ability to resolve
disseminated bacterial infections subsequent to the initial pulmonary
infection. These data indicate that -T cells comprise a critical
component of the acute inflammatory response toward extracellular
Gram-negative bacterial infections and are vital for the early
production of the proinflammatory cytokines IFN- and
TNF-.
This article has been cited by other articles:
|
|
 |
|
  F. Venet, C.-S. Chung, X. Huang, J. Lomas-Neira, Y. Chen, and A. Ayala Lymphocytes in the Development of Lung Inflammation: A Role for Regulatory CD4+ T Cells in Indirect Pulmonary Lung Injury J. Immunol., September 1, 2009; 183(5): 3472 - 3480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. O'Brien, M. A. Taylor, J. Hartley, T. Nuhsbaum, S. Dugan, K. Lahmers, M. K. Aydintug, J. M. Wands, C. L. Roark, and W. K. Born Protective Role of {gamma}{delta} T Cells in Spontaneous Ocular Inflammation Invest. Ophthalmol. Vis. Sci., July 1, 2009; 50(7): 3266 - 3274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Cogen and T. A. Moore {beta}2-Microglobulin-Dependent Bacterial Clearance and Survival during Murine Klebsiella pneumoniae Bacteremia Infect. Immun., January 1, 2009; 77(1): 360 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Hirsh and W. G. Junger Roles of Heat Shock Proteins and {gamma}{delta}T Cells in Inflammation Am. J. Respir. Cell Mol. Biol., November 1, 2008; 39(5): 509 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Sutherland, J. S. Olsen, A. McKinstry, S. A. Villalta, and P. J. Wolters Mast Cell IL-6 Improves Survival from Klebsiella Pneumonia and Sepsis by Enhancing Neutrophil Killing J. Immunol., October 15, 2008; 181(8): 5598 - 5605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-L. Small, S. McCormick, N. Gill, K. Kugathasan, M. Santosuosso, N. Donaldson, D. E. Heinrichs, A. Ashkar, and Z. Xing NK Cells Play a Critical Protective Role in Host Defense against Acute Extracellular Staphylococcus aureus Bacterial Infection in the Lung J. Immunol., April 15, 2008; 180(8): 5558 - 5568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tschop, A. Martignoni, H. S. Goetzman, L. G. Choi, Q. Wang, J. G. Noel, C. K. Ogle, T. A. Pritts, J. A. Johannigman, A. B. Lentsch, et al. {gamma}{delta} T cells mitigate the organ injury and mortality of sepsis J. Leukoc. Biol., March 1, 2008; 83(3): 581 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. R. Karaolis, M. W. Newstead, X. Zeng, M. Hyodo, Y. Hayakawa, U. Bhan, H. Liang, and T. J. Standiford Cyclic Di-GMP Stimulates Protective Innate Immunity in Bacterial Pneumonia Infect. Immun., October 1, 2007; 75(10): 4942 - 4950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Bhan, N. W. Lukacs, J. J. Osterholzer, M. W. Newstead, X. Zeng, T. A. Moore, T. R. McMillan, A. M. Krieg, S. Akira, and T. J. Standiford TLR9 Is Required for Protective Innate Immunity in Gram-Negative Bacterial Pneumonia: Role of Dendritic Cells J. Immunol., September 15, 2007; 179(6): 3937 - 3946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Li, A. R. Burns, R. E. Rumbaut, and C. W. Smith {gamma}{delta} T Cells Are Necessary for Platelet and Neutrophil Accumulation in Limbal Vessels and Efficient Epithelial Repair after Corneal Abrasion Am. J. Pathol., September 1, 2007; 171(3): 838 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Borghesi and C. Milcarek Innate versus Adaptive Immunity: A Paradigm Past Its Prime? Cancer Res., May 1, 2007; 67(9): 3989 - 3993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Kuhl, N. N. Pawlowski, K. Grollich, C. Loddenkemper, M. Zeitz, and J. C. Hoffmann Aggravation of intestinal inflammation by depletion/deficiency of {gamma}{delta} T cells in different types of IBD animal models J. Leukoc. Biol., January 1, 2007; 81(1): 168 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-S. Chung, L. Watkins, A. Funches, J. Lomas-Neira, W. G. Cioffi, and A. Ayala Deficiency of {gamma}{delta} T lymphocytes contributes to mortality and immunosuppression in sepsis Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1338 - R1343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Egan, J. E. Dalton, E. M. Andrew, J. E. Smith, M.-J. Gubbels, B. Striepen, and S. R. Carding A Requirement for the V{gamma}1+ Subset of Peripheral {gamma}{delta} T Cells in the Control of the Systemic Growth of Toxoplasma gondii and Infection-Induced Pathology J. Immunol., December 15, 2005; 175(12): 8191 - 8199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zeng, T. A. Moore, M. W. Newstead, J. C. Deng, S. L. Kunkel, A. D. Luster, and T. J. Standiford Interferon-Inducible Protein 10, but Not Monokine Induced by Gamma Interferon, Promotes Protective Type 1 Immunity in Murine Klebsiella pneumoniae Pneumonia Infect. Immun., December 1, 2005; 73(12): 8226 - 8236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Curtis Cell-mediated Adaptive Immune Defense of the Lungs Proceedings of the ATS, December 1, 2005; 2(5): 412 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Wands, C. L. Roark, M. K. Aydintug, N. Jin, Y.-S. Hahn, L. Cook, X. Yin, J. Dal Porto, M. Lahn, D. M. Hyde, et al. Distribution and leukocyte contacts of {gamma}{delta} T cells in the lung J. Leukoc. Biol., November 1, 2005; 78(5): 1086 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Maeda, P. Reddy, K. P. Lowler, C. Liu, D. K. Bishop, and J. L. M. Ferrara Critical role of host {gamma}{delta} T cells in experimental acute graft-versus-host disease Blood, July 15, 2005; 106(2): 749 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Deng, T. A. Moore, M. W. Newstead, X. Zeng, A. M. Krieg, and T. J. Standiford CpG Oligodeoxynucleotides Stimulate Protective Innate Immunity against Pulmonary Klebsiella Infection J. Immunol., October 15, 2004; 173(8): 5148 - 5155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Deng, X. Zeng, M. Newstead, T. A. Moore, W. C. Tsai, V. J. Thannickal, and T. J. Standiford STAT4 Is a Critical Mediator of Early Innate Immune Responses against Pulmonary Klebsiella Infection J. Immunol., September 15, 2004; 173(6): 4075 - 4083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Ponomarev, M. Novikova, M. Yassai, M. Szczepanik, J. Gorski, and B. N. Dittel {gamma}{delta} T Cell Regulation of IFN-{gamma} Production by Central Nervous System-Infiltrating Encephalitogenic T Cells: Correlation with Recovery from Experimental Autoimmune Encephalomyelitis J. Immunol., August 1, 2004; 173(3): 1587 - 1595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Uezu, K. Kawakami, K. Miyagi, Y. Kinjo, T. Kinjo, H. Ishikawa, and A. Saito Accumulation of {gamma}{delta} T Cells in the Lungs and Their Regulatory Roles in Th1 Response and Host Defense against Pulmonary Infection with Cryptococcus neoformans J. Immunol., June 15, 2004; 172(12): 7629 - 7634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Workalemahu, M. Foerster, and C. Kroegel Expression and synthesis of fibroblast growth factor-9 in human {gamma}{delta} T-lymphocytes. Response to isopentenyl pyrophosphate and TGF-{beta}1/IL-15 J. Leukoc. Biol., April 1, 2004; 75(4): 657 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ramsburg, R. Tigelaar, J. Craft, and A. Hayday Age-dependent Requirement for {gamma}{delta} T Cells in the Primary but Not Secondary Protective Immune Response against an Intestinal Parasite J. Exp. Med., November 3, 2003; 198(9): 1403 - 1414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Prass, C. Meisel, C. Hoflich, J. Braun, E. Halle, T. Wolf, K. Ruscher, I. V. Victorov, J. Priller, U. Dirnagl, et al. Stroke-induced Immunodeficiency Promotes Spontaneous Bacterial Infections and Is Mediated by Sympathetic Activation Reversal by Poststroke T Helper Cell Type 1-like Immunostimulation J. Exp. Med., September 2, 2003; 198(5): 725 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Moore, M. L. Perry, A. G. Getsoian, C. L. Monteleon, A. L. Cogen, and T. J. Standiford Increased Mortality and Dysregulated Cytokine Production in Tumor Necrosis Factor Receptor 1-Deficient Mice following Systemic Klebsiella pneumoniae Infection Infect. Immun., September 1, 2003; 71(9): 4891 - 4900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Gao, W. Yang, M. Pan, E. Scully, M. Girardi, L. H. Augenlicht, J. Craft, and Z. Yin {gamma}{delta} T Cells Provide an Early Source of Interferon {gamma} in Tumor Immunity J. Exp. Med., August 4, 2003; 198(3): 433 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, H. K. Lee, J. F. Bukowski, H. Li, R. A. Mariuzza, Z. W. Chen, K.-H. Nam, and C. T. Morita Conservation of Nonpeptide Antigen Recognition by Rhesus Monkey V{gamma}2V{delta}2 T Cells J. Immunol., April 1, 2003; 170(7): 3696 - 3706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zeng, T. A. Moore, M. W. Newstead, R. Hernandez-Alcoceba, W. C. Tsai, and T. J. Standiford Intrapulmonary Expression of Macrophage Inflammatory Protein 1{alpha} (CCL3) Induces Neutrophil and NK Cell Accumulation and Stimulates Innate Immunity in Murine Bacterial Pneumonia Infect. Immun., March 1, 2003; 71(3): 1306 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Moore, M. L. Perry, A. G. Getsoian, M. W. Newstead, and T. J. Standiford Divergent Role of Gamma Interferon in a Murine Model of Pulmonary versus Systemic Klebsiella pneumoniae Infection Infect. Immun., November 1, 2002; 70(11): 6310 - 6318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Steele, M. Zheng, E. Young, L. Marrero, J. E. Shellito, and J. K. Kolls Increased Host Resistance against Pneumocystis carinii Pneumonia in {gamma}{delta} T-Cell-Deficient Mice: Protective Role of Gamma Interferon and CD8+ T Cells Infect. Immun., September 1, 2002; 70(9): 5208 - 5215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Chackerian, J. M. Alt, T. V. Perera, C. C. Dascher, and S. M. Behar Dissemination of Mycobacterium tuberculosis Is Influenced by Host Factors and Precedes the Initiation of T-Cell Immunity Infect. Immun., August 1, 2002; 70(8): 4501 - 4509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mancuso, A. Gottschalk, S. M. Phare, M. Peters-Golden, N. W. Lukacs, and G. B. Huffnagle Leptin-Deficient Mice Exhibit Impaired Host Defense in Gram-Negative Pneumonia J. Immunol., April 15, 2002; 168(8): 4018 - 4024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shen, D. Zhou, L. Qiu, X. Lai, M. Simon, L. Shen, Z. Kou, Q. Wang, L. Jiang, J. Estep, et al. Adaptive Immune Response of Vgamma 2Vdelta 2+ T Cells During Mycobacterial Infections Science, March 22, 2002; 295(5563): 2255 - 2258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J Boyton and P. J Openshaw Pulmonary defences to acute respiratory infection Br. Med. Bull., March 1, 2002; 61(1): 1 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.B. Moore, T.A. Moore, and G.B. Toews Role of T- and B-;lymphocytes in pulmonary host defences Eur. Respir. J., November 1, 2001; 18(5): 846 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. L. Wormley Jr., C. Steele, K. Wozniak, K. Fujihashi, J. R. McGhee, and P. L. Fidel Jr. Resistance of T-Cell Receptor delta -Chain-Deficient Mice to Experimental Candidaalbicans Vaginitis Infect. Immun., November 1, 2001; 69(11): 7162 - 7164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Deng, K. Tateda, X. Zeng, and T. J. Standiford Transient Transgenic Expression of Gamma Interferon Promotes Legionella pneumophila Clearance in Immunocompetent Hosts Infect. Immun., October 1, 2001; 69(10): 6382 - 6390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. K. Selin, P. A. Santolucito, A. K. Pinto, E. Szomolanyi-Tsuda, and R. M. Welsh Innate Immunity to Viruses: Control of Vaccinia Virus Infection by {{gamma}}{{delta}} T Cells J. Immunol., June 1, 2001; 166(11): 6784 - 6794. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
