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The Journal of Immunology, 00, 165: 2331-2334.
Copyright © 00 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: CD7 Delivers a Pro-Apoptotic Signal During Galectin-1-Induced T Cell Death1

Karen E. Pace*, Hejin P. Hahn{dagger}, Mabel Pang*, Julie T. Nguyen* and Linda G. Baum2,*,{dagger}

* Department of Pathology and Laboratory Medicine, University of California School of Medicine, Los Angeles, CA 90095; and {dagger} Molecular Biology Institute, University of California, Los Angeles, CA 90095

Galectin-1, an endogenous lectin expressed in lymphoid organs and immune-privileged sites, induces death of human and murine thymocytes and T cells. Galectin-1 binds to several glycoproteins on the T cell surface, including CD7. However, the T cell surface glycoprotein receptors responsible for delivering the galectin-1 death signal have not been identified. We show that CD7 is required for galectin-1-mediated death. This demonstrates a novel function for CD7 as a death trigger and identifies galectin-1/CD7 as a new biologic death signaling pair.




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