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CUTTING EDGE |
*
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92612;
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037; and
Department of Immunology, The Lerner Research Institute, Cleveland, OH 44195
The contribution of the T cell chemoattractant chemokine
IFN-inducible protein 10 (IP-10) in host defense following viral
infection of the CNS was examined. IP-10 is expressed by astrocytes
during acute encephalomyelitis in mouse hepatitis virus-infected mice,
and the majority of T lymphocytes infiltrating into the CNS expressed
the IP-10 receptor CXCR3. Treatment of mice with anti-IP-10
antisera led to increased mortality and delayed viral clearance from
the CNS as compared with control mice. Further, administration of
anti-IP-10 led to a >70% reduction (p 
0.001) in CD4+ and CD8+ T lymphocyte
infiltration into the CNS, which correlated with decreased
(p 0.01) levels of IFN-
. These data indicate
that IP-10 functions as a sentinel molecule in host defense and is
essential in the development of a protective Th1 response against viral
infection of the CNS.
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W. G. Glass and T. E. Lane Functional Expression of Chemokine Receptor CCR5 on CD4+ T Cells during Virus-Induced Central Nervous System Disease J. Virol., December 6, 2002; 77(1): 191 - 198. [Abstract] [Full Text] [PDF]
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K. Kakimi, T. E. Lane, S. Wieland, V. C. Asensio, I. L. Campbell, F. V. Chisari, and L. G. Guidotti Blocking Chemokine Responsive to {gamma}-2/Interferon (IFN)-{gamma} Inducible Protein and Monokine Induced by IFN-{gamma} Activity In Vivo Reduces the Pathogenetic but not the Antiviral Potential of Hepatitis B Virus-specific Cytotoxic T Lymphocytes J. Exp. Med., December 17, 2001; 194(12): 1755 - 1766. [Abstract] [Full Text] [PDF]
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K. Kakimi, T. E. Lane, F. V. Chisari, and L. G. Guidotti Cutting Edge: Inhibition of Hepatitis B Virus Replication by Activated NK T Cells Does Not Require Inflammatory Cell Recruitment to the Liver J. Immunol., December 15, 2001; 167(12): 6701 - 6705. [Abstract] [Full Text] [PDF]
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B. P. Chen, W. A. Kuziel, and T. E. Lane Lack of CCR2 Results in Increased Mortality and Impaired Leukocyte Activation and Trafficking Following Infection of the Central Nervous System with a Neurotropic Coronavirus J. Immunol., October 15, 2001; 167(8): 4585 - 4592. [Abstract] [Full Text] [PDF]
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M. T. Liu, H. S. Keirstead, and T. E. Lane Neutralization of the Chemokine CXCL10 Reduces Inflammatory Cell Invasion and Demyelination and Improves Neurological Function in a Viral Model of Multiple Sclerosis J. Immunol., October 1, 2001; 167(7): 4091 - 4097. [Abstract] [Full Text] [PDF]
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M. Miura, K. Morita, H. Kobayashi, T. A. Hamilton, M. D. Burdick, R. M. Strieter, and R. L. Fairchild Monokine Induced by IFN-{gamma} Is a Dominant Factor Directing T Cells into Murine Cardiac Allografts During Acute Rejection J. Immunol., September 15, 2001; 167(6): 3494 - 3504. [Abstract] [Full Text] [PDF]
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V. C. Asensio, J. Maier, R. Milner, K. Boztug, C. Kincaid, M. Moulard, C. Phillipson, K. Lindsley, T. Krucker, H. S. Fox, et al. Interferon-Independent, Human Immunodeficiency Virus Type 1 gp120-Mediated Induction of CXCL10/IP-10 Gene Expression by Astrocytes In Vivo and In Vitro J. Virol., August 1, 2001; 75(15): 7067 - 7077. [Abstract] [Full Text]
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J. B. Sundstrom, L. K. McMullan, C. F. Spiropoulou, W. C. Hooper, A. A. Ansari, C. J. Peters, and P. E. Rollin Hantavirus Infection Induces the Expression of RANTES and IP-10 without Causing Increased Permeability in Human Lung Microvascular Endothelial Cells J. Virol., July 1, 2001; 75(13): 6070 - 6085. [Abstract] [Full Text] [PDF]
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B. T. Fife, K. J. Kennedy, M. C. Paniagua, N. W. Lukacs, S. L. Kunkel, A. D. Luster, and W. J. Karpus CXCL10 (IFN-{{gamma}}-Inducible Protein-10) Control of Encephalitogenic CD4+ T Cell Accumulation in the Central Nervous System During Experimental Autoimmune Encephalomyelitis J. Immunol., June 15, 2001; 166(12): 7617 - 7624. [Abstract] [Full Text] [PDF]
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B. Qiu, K. A. Frait, F. Reich, E. Komuniecki, and S. W. Chensue Chemokine Expression Dynamics in Mycobacterial (Type-1) and Schistosomal (Type-2) Antigen-Elicited Pulmonary Granuloma Formation Am. J. Pathol., April 1, 2001; 158(4): 1503 - 1515. [Abstract] [Full Text] [PDF]
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M. T. Liu, D. Armstrong, T. A. Hamilton, and T. E. Lane Expression of Mig (Monokine Induced by Interferon-{{gamma}}) Is Important in T Lymphocyte Recruitment and Host Defense Following Viral Infection of the Central Nervous System J. Immunol., February 1, 2001; 166(3): 1790 - 1795. [Abstract] [Full Text] [PDF]
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