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*
Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121;
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037;
First Department of Internal Medicine, Kumamoto University School of Medicine, Kumamoto, Japan; and
§
Department of Immunology and Immunopathology, Kagawa Medical School, Kagawa, Japan
Galectin-3 is a ß-galactoside-binding protein implicated in
diverse biological processes. We found that galectin-3 induced human
monocyte migration in vitro in a dose-dependent manner, and it was
chemotactic at high concentrations (1.0 µM) but chemokinetic at low
concentrations (10–100 nM). Galectin-3-induced monocyte migration was
inhibited by its specific mAb and was blocked by lactose and a
C-terminal domain fragment of the protein, indicating that both the
N-terminal and C-terminal domains of galectin-3 are involved in this
activity. Pertussis toxin (PTX) almost completely blocked monocyte
migration induced by high concentrations of galectin-3. Galectin-3
caused a Ca2+ influx in monocytes at high, but not low,
concentrations, and both lactose and PTX inhibited this response. There
was no cross-desensitization between galectin-3 and any of the
monocyte-reactive chemokines examined, including monocyte chemotactic
protein-1, macrophage inflammatory protein-1
, and stromal
cell-derived factor-1. Cultured human macrophages and alveolar
macrophages also migrated toward galectin-3, but not monocyte
chemotactic protein-1. Finally, galectin-3 was found to cause monocyte
accumulation in vivo in mouse air pouches. These results indicate that
galectin-3 is a novel chemoattractant for monocytes and macrophages and
suggest that the effect is mediated at least in part through a
PTX-sensitive (G protein-coupled) pathway.
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 G. C. Fernandez, J. M. Ilarregui, C. J. Rubel, M. A. Toscano, S. A. Gomez, M. Beigier Bompadre, M. A. Isturiz, G. A. Rabinovich, and M. S. Palermo Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: involvement of alternative MAPK pathways Glycobiology, May 1, 2005; 15(5): 519 - 527. [Abstract] [Full Text] [PDF]
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R. I. Zuberi, D. K. Hsu, O. Kalayci, H.-Y. Chen, H. K. Sheldon, L. Yu, J. R. Apgar, T. Kawakami, C. M. Lilly, and F.-T. Liu Critical Role for Galectin-3 in Airway Inflammation and Bronchial Hyperresponsiveness in a Murine Model of Asthma Am. J. Pathol., December 1, 2004; 165(6): 2045 - 2053. [Abstract] [Full Text] [PDF]
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Y. Y. Kleshchenko, T. N. Moody, V. A. Furtak, J. Ochieng, M. F. Lima, and F. Villalta Human Galectin-3 Promotes Trypanosoma cruzi Adhesion to Human Coronary Artery Smooth Muscle Cells Infect. Immun., November 1, 2004; 72(11): 6717 - 6721. [Abstract] [Full Text] [PDF]
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 D. Houzelstein, I. R. Goncalves, A. J. Fadden, S. S. Sidhu, D. N. W. Cooper, K. Drickamer, H. Leffler, and F. Poirier Phylogenetic Analysis of the Vertebrate Galectin Family Mol. Biol. Evol., July 1, 2004; 21(7): 1177 - 1187. [Abstract] [Full Text] [PDF]
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T. Shimaoka, T. Nakayama, K. Hieshima, N. Kume, N. Fukumoto, M. Minami, K. Hayashida, T. Kita, O. Yoshie, and S. Yonehara Chemokines Generally Exhibit Scavenger Receptor Activity through Their Receptor-binding Domain J. Biol. Chem., June 25, 2004; 279(26): 26807 - 26810. [Abstract] [Full Text] [PDF]
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W. Savino, D. A. Mendes-da-Cruz, S. Smaniotto, E. Silva-Monteiro, and D. M. S. Villa-Verde Molecular mechanisms governing thymocyte migration: combined role of chemokines and extracellular matrix J. Leukoc. Biol., June 1, 2004; 75(6): 951 - 961. [Abstract] [Full Text] [PDF]
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K. K. Hoyer, M. Pang, D. Gui, I. P. Shintaku, I. Kuwabara, F.-T. Liu, J. W. Said, L. G. Baum, and M. A. Teitell An Anti-Apoptotic Role for Galectin-3 in Diffuse Large B-Cell Lymphomas Am. J. Pathol., March 1, 2004; 164(3): 893 - 902. [Abstract] [Full Text] [PDF]
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 T. Fukumori, Y. Takenaka, T. Yoshii, H.-R. C. Kim, V. Hogan, H. Inohara, S. Kagawa, and A. Raz CD29 and CD7 Mediate Galectin-3-Induced Type II T-Cell Apoptosis Cancer Res., December 1, 2003; 63(23): 8302 - 8311. [Abstract] [Full Text] [PDF]
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N. Nishi, H. Shoji, M. Seki, A. Itoh, H. Miyanaka, K. Yuube, M. Hirashima, and T. Nakamura Galectin-8 modulates neutrophil function via interaction with integrin {alpha}M Glycobiology, November 1, 2003; 13(11): 755 - 763. [Abstract] [Full Text] [PDF]
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K. Vandal, P. Rouleau, A. Boivin, C. Ryckman, M. Talbot, and P. A. Tessier Blockade of S100A8 and S100A9 Suppresses Neutrophil Migration in Response to Lipopolysaccharide J. Immunol., September 1, 2003; 171(5): 2602 - 2609. [Abstract] [Full Text] [PDF]
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M. J. Abedin, Y. Kashio, M. Seki, K. Nakamura, and M. Hirashima Potential roles of galectins in myeloid differentiation into three different lineages J. Leukoc. Biol., May 1, 2003; 73(5): 650 - 656. [Abstract] [Full Text] [PDF]
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Y. Kashio, K. Nakamura, M. J. Abedin, M. Seki, N. Nishi, N. Yoshida, T. Nakamura, and M. Hirashima Galectin-9 Induces Apoptosis Through the Calcium-Calpain-Caspase-1 Pathway J. Immunol., April 1, 2003; 170(7): 3631 - 3636. [Abstract] [Full Text] [PDF]
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S. G. Correa, C. E. Sotomayor, M. P. Aoki, C. A. Maldonado, and G. A. Rabinovich Opposite effects of galectin-1 on alternative metabolic pathways of L-arginine in resident, inflammatory, and activated macrophages Glycobiology, February 1, 2003; 13(2): 119 - 128. [Abstract] [Full Text] [PDF]
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 T. K. Mandal and C. Mukhopadhyay Binding free energy calculations of galectin-3-ligand interactions Protein Eng. Des. Sel., December 1, 2002; 15(12): 979 - 986. [Abstract] [Full Text] [PDF]
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G. A. Rabinovich, N. Rubinstein, and L. Fainboim Unlocking the secrets of galectins: a challenge at the frontier of glyco-immunology J. Leukoc. Biol., May 1, 2002; 71(5): 741 - 752. [Abstract] [Full Text] [PDF]
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J. L. Dunphy, G. J. Barcham, R. J. Bischof, A. R. Young, A. Nash, and E. N. T. Meeusen Isolation and Characterization of a Novel Eosinophil-specific Galectin Released into the Lungs in Response to Allergen Challenge J. Biol. Chem., April 19, 2002; 277(17): 14916 - 14924. [Abstract] [Full Text] [PDF]
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S. Sato, N. Ouellet, I. Pelletier, M. Simard, A. Rancourt, and M. G. Bergeron Role of Galectin-3 as an Adhesion Molecule for Neutrophil Extravasation During Streptococcal Pneumonia J. Immunol., February 15, 2002; 168(4): 1813 - 1822. [Abstract] [Full Text] [PDF]
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J. Mengwasser, F.-T. Liu, and J. P. Sleeman Galectin-3 is strongly up-regulated in nonapoptosing mammary epithelial cells during rat mammary gland involution Glycobiology, February 1, 2002; 12(2): 129 - 134. [Abstract] [Full Text] [PDF]
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 J. Chillaron, R. Roca, A. Valencia, A. Zorzano, and M. Palacin Heteromeric amino acid transporters: biochemistry, genetics, and physiology Am J Physiol Renal Physiol, December 1, 2001; 281(6): F995 - F1018. [Abstract] [Full Text] [PDF]
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R.-Y. Yang, D. K. Hsu, L. Yu, J. Ni, and F.-T. Liu Cell Cycle Regulation by Galectin-12, a New Member of the Galectin Superfamily J. Biol. Chem., June 1, 2001; 276(23): 20252 - 20260. [Abstract] [Full Text] [PDF]
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