| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Partners AIDS Research Center and
Massachusetts General Hospital Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129; and
Universitaets Spital Zurich, University of Zurich, Zurich, Switzerland
Kaposi’s sarcoma-associated herpes virus (KSHV) is a recently
identified human 
2-herpesvirus associated with Kaposi’s sarcoma,
primary effusion lymphoma, and Castleman’s disease. We reasoned that
CTL responses may provide host defense against this virus, and
consequently, KSHV may have evolved strategies to evade the
CTL-mediated immune surveillance. In this study six B cell lines
latently infected with KSHV were found to express reduced levels of HLA
class I surface molecules compared with B cell lines transformed by the
related -herpesvirus EBV. KSHV-infected cells also required higher
concentrations of soluble peptides to induce efficient CTL-mediated
lysis than control cell lines and were unable to process and/or present
intracellularly expressed Ag. Incubation of the KSHV-infected cell
lines with high concentrations of soluble HLA class I binding peptides
did not restore the deficient HLA class I surface expression. To assess
the underlying mechanisms of these phenomena, TAP-1 and TAP-2 gene
expression was analyzed. While no attenuation in TAP-2 expression was
observed, TAP-1 expression was significantly reduced in all KSHV cell
lines compared with that in controls. These results indicate that KSHV
can modulate HLA class I-restricted Ag presentation to CTL, which may
allow latently infected cells to escape CTL recognition and persist in
the infected host.
This article has been cited by other articles:
|
|
 |
|
  K. Lan, S. C. Verma, M. Murakami, B. Bajaj, R. Kaul, and E. S. Robertson Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein PNAS, October 9, 2007; 104(41): 16287 - 16292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lambert, M. Gannage, A. Karras, M. Abel, C. Legendre, D. Kerob, F. Agbalika, P.-M. Girard, C. Lebbe, and S. Caillat-Zucman Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma Blood, December 1, 2006; 108(12): 3871 - 3880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. R. Rezaee, C. Cunningham, A. J. Davison, and D. J. Blackbourn Kaposi's sarcoma-associated herpesvirus immune modulation: an overview J. Gen. Virol., July 1, 2006; 87(7): 1781 - 1804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ribechini, C. Fortini, M. Marastoni, S. Traniello, S. Spisani, P. Monini, and R. Gavioli Identification of CD8+ T Cell Epitopes within Lytic Antigens of Human Herpes Virus 8 J. Immunol., January 15, 2006; 176(2): 923 - 930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Lan, D. A. Kuppers, S. C. Verma, N. Sharma, M. Murakami, and E. S. Robertson Induction of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen by the Lytic Transactivator RTA: a Novel Mechanism for Establishment of Latency J. Virol., June 15, 2005; 79(12): 7453 - 7465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lan, D. A. Kuppers, and E. S. Robertson Kaposi's Sarcoma-Associated Herpesvirus Reactivation Is Regulated by Interaction of Latency-Associated Nuclear Antigen with Recombination Signal Sequence-Binding Protein J{kappa}, the Major Downstream Effector of the Notch Signaling Pathway J. Virol., March 15, 2005; 79(6): 3468 - 3478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tomescu, W. K. Law, and D. H. Kedes Surface Downregulation of Major Histocompatibility Complex Class I, PE-CAM, and ICAM-1 following De Novo Infection of Endothelial Cells with Kaposi's Sarcoma-Associated Herpesvirus J. Virol., September 1, 2003; 77(17): 9669 - 9684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Aoki, G. M. Feldman, and G. Tosato Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma Blood, February 15, 2003; 101(4): 1535 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li, T. Komatsu, B. J. Dezube, and K. M. Kaye The Kaposi's Sarcoma-Associated Herpesvirus K12 Transcript from a Primary Effusion Lymphoma Contains Complex Repeat Elements, Is Spliced, and Initiates from a Novel Promoter J. Virol., October 25, 2002; 76(23): 11880 - 11888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Aoki, R. Yarchoan, K. Wyvill, S.-i. Okamoto, R. F. Little, and G. Tosato Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders Blood, April 1, 2001; 97(7): 2173 - 2176. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
