HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ramírez, F. Articles by Mason, D. Search for Related Content PubMed PubMed Citation Articles by Ramírez, F. Articles by Mason, D.

Recirculatory and Sessile CD4⁺ T Lymphocytes Differ on CD45RC Expression¹

Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

CD4⁺ T cell subsets are unequally distributed in rat secondary lymphoid organs. Those with the memory phenotype CD45RC^low Thy-1^- L-selectin^- are present at a higher frequency in Peyer’s patches (PP) than in lymph nodes and spleen, and increase in numbers with age in all three tissues, particularly in the PP. Homing experiments revealed that CD4⁺ T cells that recirculate through secondary lymphoid organs are mainly CD45RC^high. It was also apparent that the ability of recirculating cells to enter different lymphoid organs varies; less cells enter PP than the spleen or lymph nodes. Our results also reveal the existence of a nonrecirculating population of CD4⁺ T cells in secondary lymphoid organs, which are predominantly, if not exclusively, CD45RC^low. Our results show that secondary lymphoid organs differ in their CD4⁺ T cell subset composition as a consequence of having different ratios of recirculatory:nonrecirculatory CD4⁺ T cells, and these cells display a different CD45RC phenotype.

This article has been cited by other articles:

				M. Henkel, O. Planz, T. Fischer, L. Stitz, and H.-J. Rziha Prevention of Virus Persistence and Protection against Immunopathology after Borna Disease Virus Infection of the Brain by a Novel Orf Virus Recombinant J. Virol., January 1, 2005; 79(1): 314 - 325. [Abstract] [Full Text] [PDF]

				C. P. Cunningham, W. G. Kimpton, A. Fernando, and R. N. P. Cahill Neonatal thymectomy identifies two major pools of sessile and recirculating peripheral T cells which appear to be under separate homeostatic control Int. Immunol., November 1, 2001; 13(11): 1351 - 1359. [Abstract] [Full Text] [PDF]