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Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada; and
Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Little is known regarding the ligand specificity of Ly-49
activating receptor subfamily members expressed by NK cells. A new
Ly-49 activating receptor related to Ly-49A in its extracellular
domain, designated Ly-49P, was recently cloned from 129 strain mice. We
independently cloned an apparent allele of Ly-49P expressed by nonobese
diabetic and nonobese diabetes-resistant mouse strain NK cells. We
found it to be reactive with the A1 Ab thought to recognize a
polymorphic epitope expressed only by the Ly-49A inhibitory receptor of
the C57BL/6 strain. Rat RNK-16 cells transfected with Ly-49P mediated
reverse Ab-dependent cellular cytotoxicity of FcR-positive target
cells, indicating that Ly-49P can activate NK-mediated lysis. We
determined that RNK-16 lysis of Con A blasts induced by Ly-49P was MHC
dependent, resulting in efficient lysis of H-2Dd-bearing
targets. We found that the Dd 
1/2 domain is required
for Ly-49P-mediated RNK-16 activation, as determined by exon shuffling
and transfection. Thus, Ly-49P is the second activating Ly-49 receptor
demonstrated to induce NK cytotoxicity by recognizing a class I MHC
molecule.
This article has been cited by other articles:
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 L. Poirot, C. Benoist, and D. Mathis Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity PNAS, May 25, 2004; 101(21): 8102 - 8107. [Abstract] [Full Text] [PDF]
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B. J. Ma, E. T. Silver, B. Hazes, and K. P. Kane Reciprocal Transfer of Class I MHC Allele Specificity between Activating Ly-49P and Ly-49W Receptors by Exchange of {beta}4-{beta}5 Loop Residues J. Immunol., November 15, 2003; 171(10): 5337 - 5344. [Abstract] [Full Text] [PDF]
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H. Furukawa, K. Iizuka, J. Poursine-Laurent, N. Shastri, and W. M. Yokoyama A Ligand for the Murine NK Activation Receptor Ly-49D: Activation of Tolerized NK Cells from {beta}2-Microglobulin- Deficient Mice J. Immunol., July 1, 2002; 169(1): 126 - 136. [Abstract] [Full Text] [PDF]
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A. Saleh, A. P. Makrigiannis, D. L. Hodge, and S. K. Anderson Identification of a Novel Ly49 Promoter That Is Active in Bone Marrow and Fetal Thymus J. Immunol., May 15, 2002; 168(10): 5163 - 5169. [Abstract] [Full Text] [PDF]
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 J. Zimmer, V. Ioannidis, and W. Held H-2D Ligand Expression by Ly49A+ Natural Killer (NK) Cells Precludes Ligand Uptake from Environmental Cells: Implications for NK Cell Function J. Exp. Med., November 19, 2001; 194(10): 1531 - 1539. [Abstract] [Full Text] [PDF]
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A. P. Makrigiannis, A. T. Pau, A. Saleh, R. Winkler-Pickett, J. R. Ortaldo, and S. K. Anderson Class I MHC-Binding Characteristics of the 129/J Ly49 Repertoire J. Immunol., April 15, 2001; 166(8): 5034 - 5043. [Abstract] [Full Text] [PDF]
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E. T. Silver, D.-E. Gong, B. Hazes, and K. P. Kane Ly-49W, an Activating Receptor of Nonobese Diabetic Mice With Close Homology to the Inhibitory Receptor Ly-49G, Recognizes H-2Dk and H-2Dd J. Immunol., February 15, 2001; 166(4): 2333 - 2341. [Abstract] [Full Text] [PDF]
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C. Carnaud, J.-M. Gombert, O. Donnars, H.-J. Garchon, and A. Herbelin Protection Against Diabetes and Improved NK/NKT Cell Performance in NOD.NK1.1 Mice Congenic at the NK Complex J. Immunol., February 15, 2001; 166(4): 2404 - 2411. [Abstract] [Full Text] [PDF]
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