| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
2 in B Cell Development and Function1
*
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan;
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan;
First Department of Pathology, Kansai Medical University, Moriguchi, Japan; and
§
Department of Biomolecular Sciences, Fukushima Medical College, Fukushima, Japan
Cross-linking of the B cell Ag receptor (BCR) induces the
tyrosine phosphorylation of multiple cellular
substrates, including phospholipase C (PLC)-
2, which is involved in
the activation of the phosphatidylinositol pathway. To assess the
importance of PLC-2 in murine lymphopoiesis, the PLC-2 gene was
inducibly ablated by using IFN-regulated Cre recombinase. Mice with a
neonatally induced loss of PLC-2 function displayed reduced numbers
of mature conventional B cells and peritoneal B1 cells and defective
responses in vitro to BCR stimulation and in vivo to immunization with
thymus-independent type II Ags. In contrast, T cell development and
TCR-mediated proliferation were normal. Taken together, PLC-2 is a
critical component of BCR signaling pathways and is required to promote
B cell development.
This article has been cited by other articles:
|
|
 |
|
  M. Hikida, S. Casola, N. Takahashi, T. Kaji, T. Takemori, K. Rajewsky, and T. Kurosaki PLC-{gamma}2 is essential for formation and maintenance of memory B cells J. Exp. Med., March 16, 2009; 206(3): 681 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Oda, T. Ono, M. Yamamoto, R. Goitsuka, and D. Kitamura PKC{eta} directs induction of IRF-4 expression and Ig {kappa} gene rearrangement in pre-BCR signaling pathway Int. Immunol., November 1, 2008; 20(11): 1417 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, X. Wang, L. Di, G. Fu, Y. Chen, L. Bai, J. Liu, X. Feng, J. M. McDonald, S. Michalek, et al. Phospholipase C{gamma}2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis J. Biol. Chem., October 24, 2008; 283(43): 29593 - 29601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Weber, B. Treanor, D. Depoil, H. Shinohara, N. E. Harwood, M. Hikida, T. Kurosaki, and F. D. Batista Phospholipase C-{gamma}2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen J. Exp. Med., April 14, 2008; 205(4): 853 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hidano, H. Sasanuma, K. Ohshima, K.-i. Seino, L. Kumar, K. Hayashi, M. Hikida, T. Kurosaki, M. Taniguchi, R. S. Geha, et al. Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-{gamma} production Int. Immunol., March 1, 2008; 20(3): 345 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Aki, Y. Minoda, H. Yoshida, S. Watanabe, R. Yoshida, G. Takaesu, T. Chinen, T. Inaba, M. Hikida, T. Kurosaki, et al. Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells. Genes Cells, February 1, 2008; 13(2): 199 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Bai, Y. Chen, Y. He, X. Dai, X. Lin, R. Wen, and D. Wang Phospholipase C{gamma}2 Contributes to Light-Chain Gene Activation and Receptor Editing Mol. Cell. Biol., September 1, 2007; 27(17): 5957 - 5967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yamasaki, K. Sakata-Sogawa, A. Hasegawa, T. Suzuki, K. Kabu, E. Sato, T. Kurosaki, S. Yamashita, M. Tokunaga, K. Nishida, et al. Zinc is a novel intracellular second messenger J. Cell Biol., May 21, 2007; 177(4): 637 - 645. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Xu, K.-G. Lee, J. Huo, T. Kurosaki, and K.-P. Lam Combined deficiencies in Bruton tyrosine kinase and phospholipase C{gamma}2 arrest B-cell development at a pre-BCR+ stage Blood, April 15, 2007; 109(8): 3377 - 3384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wen, Y. Chen, L. Bai, G. Fu, J. Schuman, X. Dai, H. Zeng, C. Yang, R. P. Stephan, J. L. Cleveland, et al. Essential Role of Phospholipase C{gamma}2 in Early B-Cell Development and Myc-Mediated Lymphomagenesis Mol. Cell. Biol., December 15, 2006; 26(24): 9364 - 9376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Xu, J. Huo, W.-K. Chew, M. Hikida, T. Kurosaki, and K.-P. Lam Phospholipase C{gamma}2 Dosage Is Critical for B Cell Development in the Absence of Adaptor Protein BLNK. J. Immunol., April 15, 2006; 176(8): 4690 - 4698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Caraux, N. Kim, S. E. Bell, S. Zompi, T. Ranson, S. Lesjean-Pottier, M. E. Garcia-Ojeda, M. Turner, and F. Colucci Phospholipase C-{gamma}2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells Blood, February 1, 2006; 107(3): 994 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Dai, Y. Chen, J. Schuman, Z. Hua, J. W. Adamson, R. Wen, and D. Wang Distinct Roles of Phosphoinositide-3 Kinase and Phospholipase C{gamma}2 in B-Cell Receptor-Mediated Signal Transduction Mol. Cell. Biol., January 1, 2006; 26(1): 88 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Upshaw, R. A. Schoon, C. J. Dick, D. D. Billadeau, and P. J. Leibson The Isoforms of Phospholipase C-{gamma} Are Differentially Used by Distinct Human NK Activating Receptors J. Immunol., July 1, 2005; 175(1): 213 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mizuno and T. L. Rothstein B Cell Receptor (BCR) Cross-Talk: CD40 Engagement Creates an Alternate Pathway for BCR Signaling That Activates I{kappa}B Kinase/I{kappa}B{alpha}/NF-{kappa}B without the Need for PI3K and Phospholipase C{gamma} J. Immunol., May 15, 2005; 174(10): 6062 - 6070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Moreno-Garcia, L. N. Lopez-Bojorques, A. Zentella, L. A. Humphries, D. J. Rawlings, and L. Santos-Argumedo CD38 Signaling Regulates B Lymphocyte Activation via a Phospholipase C (PLC)-{gamma}2-Independent, Protein Kinase C, Phosphatidylcholine-PLC, and Phospholipase D-Dependent Signaling Cascade J. Immunol., March 1, 2005; 174(5): 2687 - 2695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Pike and M. J. H. Ratcliffe Dual Requirement for the Ig{alpha} Immunoreceptor Tyrosine-Based Activation Motif (ITAM) and a Conserved Non-Ig{alpha} ITAM Tyrosine in Supporting Ig{alpha}{beta}-Mediated B Cell Development J. Immunol., February 15, 2005; 174(4): 2012 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Humphries, C. Dangelmaier, K. Sommer, K. Kipp, R. M. Kato, N. Griffith, I. Bakman, C. W. Turk, J. L. Daniel, and D. J. Rawlings Tec Kinases Mediate Sustained Calcium Influx via Site-specific Tyrosine Phosphorylation of the Phospholipase C{gamma} Src Homology 2-Src Homology 3 Linker J. Biol. Chem., September 3, 2004; 279(36): 37651 - 37661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Vigorito, G. Bardi, J. Glassford, E. W.-F. Lam, E. Clayton, and M. Turner Vav-Dependent and Vav-Independent Phosphatidylinositol 3-Kinase Activation in Murine B Cells Determined by the Nature of the Stimulus J. Immunol., September 1, 2004; 173(5): 3209 - 3214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamamoto, T. Nojima, K. Hayashi, R. Goitsuka, K. Furukawa, T. Azuma, and D. Kitamura BASH-deficient mice: limited primary repertoire and antibody formation, but sufficient affinity maturation and memory B cell generation, in anti-NP response Int. Immunol., August 1, 2004; 16(8): 1161 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Marafioti, M. Pozzobon, M.-L. Hansmann, G. Delsol, S. A. Pileri, and D. Y. Mason Expression of intracellular signaling molecules in classical and lymphocyte predominance Hodgkin disease Blood, January 1, 2004; 103(1): 188 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Oh-hora, S. Johmura, A. Hashimoto, M. Hikida, and T. Kurosaki Requirement for Ras Guanine Nucleotide Releasing Protein 3 in Coupling Phospholipase C-{gamma}2 to Ras in B Cell Receptor Signaling J. Exp. Med., December 15, 2003; 198(12): 1841 - 1851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Layseca-Espinosa, G. Pedraza-Alva, J. L. Montiel, R. del Rio, N. A. Fierro, R. Gonzalez-Amaro, and Y. Rosenstein T cell aggregation induced through CD43: intracellular signals and inhibition by the immunomodulatory drug leflunomide J. Leukoc. Biol., December 1, 2003; 74(6): 1083 - 1093. [Abstract] [Full Text]
|
|
|
|
|
|
M. Hikida, S. Johmura, A. Hashimoto, M. Takezaki, and T. Kurosaki Coupling Between B Cell Receptor and Phospholipase C-{gamma}2 Is Essential for Mature B Cell Development J. Exp. Med., August 18, 2003; 198(4): 581 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Manning, W. R. Mathews, L. P. Fico, and J. R. Thackeray Phospholipase C-{gamma} Contains Introns Shared by src Homology 2 Domains in Many Unrelated Proteins Genetics, June 1, 2003; 164(2): 433 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mankidy, J. Hastings, and J. R. Thackeray Distinct Phospholipase C-{gamma}-Dependent Signaling Pathways in the Drosophila Eye and Wing Are Revealed by a New small wing Allele Genetics, June 1, 2003; 164(2): 553 - 563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Whyburn, K. E. Halcomb, C. M. Contreras, R. Pappu, O. N. Witte, A. C. Chan, and A. B. Satterthwaite Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton's tyrosine kinase Int. Immunol., March 1, 2003; 15(3): 383 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Miosge, J. Blasioli, M. Blery, and C. C. Goodnow Analysis of an Ethylnitrosourea-generated Mouse Mutation Defines a Cell Intrinsic Role of Nuclear Factor {kappa}B2 in Regulating Circulating B Cell Numbers J. Exp. Med., October 21, 2002; 196(8): 1113 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ozdener, C. Dangelmaier, B. Ashby, S. P. Kunapuli, and J. L. Daniel Activation of Phospholipase Cgamma 2 by Tyrosine Phosphorylation Mol. Pharmacol., September 1, 2002; 62(3): 672 - 679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Xu and K.-P. Lam Delayed Cellular Maturation and Decreased Immunoglobulin {kappa} Light Chain Production In Immature B Lymphocytes Lacking B Cell Linker Protein J. Exp. Med., July 15, 2002; 196(2): 197 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamazaki, K. Takeda, K. Gotoh, H. Takeshima, S. Akira, and T. Kurosaki Essential Immunoregulatory Role for BCAP in B Cell Development and Function J. Exp. Med., February 25, 2002; 195(5): 535 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Inui, K. Maeda, D. R. Hua, T. Yamashita, H. Yamamoto, E. Miyamoto, S. Aizawa, and N. Sakaguchi BCR signal through {alpha}4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation Int. Immunol., February 1, 2002; 14(2): 177 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Inabe and T. Kurosaki Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement Blood, January 15, 2002; 99(2): 584 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Inabe, M. Ishiai, A. M. Scharenberg, N. Freshney, J. Downward, and T. Kurosaki Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation J. Exp. Med., January 14, 2002; 195(2): 189 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Niiro, A. Maeda, T. Kurosaki, and E. A. Clark The B Lymphocyte Adaptor Molecule of 32 kD (Bam32) Regulates B Cell Antigen Receptor Signaling and Cell Survival J. Exp. Med., January 7, 2002; 195(1): 143 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Watanabe, S. Hashimoto, M. Ishiai, M. Matsushita, Y. Baba, T. Kishimoto, T. Kurosaki, and S. Tsukada Four Tyrosine Residues in Phospholipase C-gamma 2, Identified as Btk-dependent Phosphorylation Sites, Are Required for B Cell Antigen Receptor-coupled Calcium Signaling J. Biol. Chem., October 12, 2001; 276(42): 38595 - 38601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kaisho, K. Takeda, T. Tsujimura, T. Kawai, F. Nomura, N. Terada, and S. Akira I{kappa}b Kinase {alpha} Is Essential for Mature B Cell Development and Function J. Exp. Med., February 19, 2001; 193(4): 417 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Wortis and R. Berland Cutting Edge Commentary: Origins of B-1 Cells J. Immunol., February 15, 2001; 166(4): 2163 - 2166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E.-L. Tan, S.-C. Wong, S. K.-E. Gan, S. Xu, and K.-P. Lam The Adaptor Protein BLNK Is Required for B Cell Antigen Receptor-induced Activation of Nuclear Factor-kappa B and Cell Cycle Entry and Survival of B Lymphocytes J. Biol. Chem., June 1, 2001; 276(23): 20055 - 20063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. Reynolds, L. A. Smyth, T. Norton, N. Freshney, J. Downward, D. Kioussis, and V. L.J. Tybulewicz Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-{gamma}1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways J. Exp. Med., May 6, 2002; 195(9): 1103 - 1114. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
