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CUTTING EDGE |
*
Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, Germany;
Microscopy Unit, Max-Planck-Institute for Infection Biology, Berlin, Germany;
Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands;
§
Department of Internal Medicine, University of Saarland, Homburg, Germany; and
¶
Department of Bacteriology, Nara Medical University, Nara, Japan
In contrast to peripheral lymphoid organs, in the liver a high proportion of T cells are CD4+NKT cells. We have previously reported that LFA-1 plays a pivotal role in the homing of thymic CD4+NKT cells to the liver. In the present study, we further assessed which cell type participates in the homing of thymic CD4+NKT cells to the liver. The accumulation of donor thymocyte-derived CD4+NKT cells in the liver of SCID mice that had been reconstituted with thymocytes from C57BL/6 mice was severely impaired by in vivo depletion of NK cells, but not Kupffer cells in recipients. These results suggest that NK cells participate in the homing of thymic CD4+NKT cells to the liver. We assume that LFA-1 expressed on NK cells is involved in this mechanism.
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