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Soluble CD8 Attenuates Cytotoxic T Cell Responses Against Replication-Defective Adenovirus Affording Transprotection of Transgenes In Vivo¹

YuFeng Peng^*, Erik Falck-Pedersen and Keith B. Elkon^2,*

Departments of ^* Medicine and Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021

The T cell coreceptor, CD8, enhances T cell-APC interactions. Because soluble CD8 homodimers can antagonize CD8 T cell activation in vitro, we asked whether secretion of soluble CD8 would effect cytotoxic T cell responses in vivo. Production of soluble CD8 by a replication-defective adenovirus vector allowed persistent virus expression for up to 5 mo in C57BL/6 mice and protected a second foreign transgene from rapid deletion. Soluble CD8 selectively inhibited CD8 T cell proliferation and IFN- production and could also attenuate peptide-specific CD8 T cell responses in vivo. These finding suggest that gene vector delivery of soluble CD8 may have therapeutic applications.

This article has been cited by other articles:

				Y. Peng, E. Falck-Pedersen, and K. B. Elkon Variation in Adenovirus Transgene Expression between BALB/c and C57BL/6 Mice Is Associated with Differences in Interleukin-12 and Gamma Interferon Production and NK Cell Activation J. Virol., May 15, 2001; 75(10): 4540 - 4550. [Abstract] [Full Text]