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RI on Rat Eosinophils and Macrophages
*
Institut National de la Santé et Recherche Médicale, Unité 167, Institut Pasteur de Lille, and
Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8526, Institut de Biologie de Lille, Lille, France
Besides its crucial role in type I hypersensitivity reactions, IgE
is involved in anti-parasite immunity. This role has been clearly
demonstrated in both human and rat schistosomiasis, but remains
controversial in the mouse. Since the cellular distribution of the high
affinity IgE receptor, Fc
RI, differs in humans and mice, it might
explain the differences in effector function of IgE between the two
species. In humans, eosinophils and macrophages induce IgE-dependent
cytotoxicity toward Schistosoma mansoni larvae, which
involves FcRI in the case of eosinophils. In the present study, we
have investigated the expression and function of FcRI in rat
eosinophils and macrophages. We demonstrate, by flow cytometry,
fluorescence microscopy, and Western blot analysis, that in rats, as in
humans, a functional 
2 trimeric FcRI is expressed
on eosinophils and macrophages. We also show that these two cell types
can induce IgE-mediated, FcRI-dependent cellular cytotoxicity toward
schistosomula. These results thus provide a molecular basis for the
differences observed between rat and mouse regarding IgE-mediated
anti-parasite immunity.
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