| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Production by NK Cells1
*
First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan;
Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan;
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; and
§
Fujisaki Institute, Hayashibara Biochemical Laboratories, Okayama, Japan
The aim of this study was to examine the contribution of IL-18 in
host defense against infection caused by Cryptococcus
neoformans in mice with defective IL-12 production. Experiments
were conducted in mice with a targeted disruption of the gene for
IL-12p40 subunit (IL-12p40-/- mice). In these
mice, host resistance was impaired, as shown by increased number of
organisms in both lungs and brains, compared with control mice. Serum
IFN-
was still detected in these mice at a considerable level
(20–30% of that in control mice). The host resistance was moderately
impaired in IL-12p40-/- mice compared with
IFN--/- mice. Neutralizing
anti-IFN- mAb further increased the lung burdens of organisms.
In addition, treatment with neutralizing anti-IL-18 Ab almost
completely abrogated the production of IFN- and also impaired the
host resistance. Host resistance in
IL-12p40-/-
IL-18-/- mice was more profoundly impaired
than in IL-12p40-/- mice. Administration of
IL-12 as well as IL-18 increased the serum levels of IFN- and
significantly restored the reduced host resistance. Spleen cells
obtained from infected IL-12p40-/- mice did
not produce any IFN- upon restimulation with the same organisms,
while those from infected and IL-12-treated mice produced IFN-. In
contrast, IL-18 did not show such effect. Finally, depletion of NK
cells by anti-asialo GM1 Ab mostly abrogated the residual
production of IFN- in IL-12p40-/- mice.
Our results indicate that IL-18 contributes to host resistance to
cryptococcal infection through the induction of IFN- production by
NK cells, but not through the development of Th1 cells, under the
condition in which IL-12 synthesis is deficient.
This article has been cited by other articles:
|
|
 |
|
  M. Lochner, K. Kastenmuller, M. Neuenhahn, H. Weighardt, D. H. Busch, W. Reindl, and I. Forster Decreased Susceptibility of Mice to Infection with Listeria monocytogenes in the Absence of Interleukin-18 Infect. Immun., September 1, 2008; 76(9): 3881 - 3890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Biondo, A. Midiri, M. Gambuzza, E. Gerace, M. Falduto, R. Galbo, A. Bellantoni, C. Beninati, G. Teti, T. Leanderson, et al. IFN-{alpha}/{beta} Signaling Is Required for Polarization of Cytokine Responses toward a Protective Type 1 Pattern during Experimental Cryptococcosis J. Immunol., July 1, 2008; 181(1): 566 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-H. Chen, M. A. Olszewski, R. A. McDonald, J. C. Wells, R. Paine III, G. B. Huffnagle, and G. B. Toews Role of Granulocyte Macrophage Colony-Stimulating Factor in Host Defense Against Pulmonary Cryptococcus neoformans Infection during Murine Allergic Bronchopulmonary Mycosis Am. J. Pathol., March 1, 2007; 170(3): 1028 - 1040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Salvatore, M. Fonseca-Aten, K. Katz-Gaynor, A. M. Gomez, A. Mejias, C. Somers, S. Chavez-Bueno, G. H. McCracken, and R. D. Hardy Respiratory Tract Infection with Mycoplasma pneumoniae in Interleukin-12 Knockout Mice Results in Improved Bacterial Clearance and Reduced Pulmonary Inflammation Infect. Immun., January 1, 2007; 75(1): 236 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Snelgrove, L. Edwards, A. E. Williams, A. J. Rae, and T. Hussell In the Absence of Reactive Oxygen Species, T Cells Default to a Th1 Phenotype and Mediate Protection against Pulmonary Cryptococcus neoformans Infection J. Immunol., October 15, 2006; 177(8): 5509 - 5516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Rowland, G. Lertmemongkolchai, A. Bancroft, A. Haque, M. S. Lever, K. F. Griffin, M. C. Jackson, M. Nelson, A. O'Garra, R. Grencis, et al. Critical Role of Type 1 Cytokines in Controlling Initial Infection with Burkholderia mallei Infect. Immun., September 1, 2006; 74(9): 5333 - 5340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Mavoungou Interactions between natural killer cells, cortisol and prolactin in malaria during pregnancy. Clin. Med. Res., March 1, 2006; 4(1): 33 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Woldbaek, J. B. Sande, T. A. Stromme, P. K. Lunde, S. Djurovic, T. Lyberg, G. Christensen, and T. Tonnessen Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H708 - H714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Arora, Y. Hernandez, J. R. Erb-Downward, R. A. McDonald, G. B. Toews, and G. B. Huffnagle Role of IFN-{gamma} in Regulating T2 Immunity and the Development of Alternatively Activated Macrophages during Allergic Bronchopulmonary Mycosis J. Immunol., May 15, 2005; 174(10): 6346 - 6356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-H. Chen, R. A. McDonald, J. C. Wells, G. B. Huffnagle, N. W. Lukacs, and G. B. Toews The Gamma Interferon Receptor Is Required for the Protective Pulmonary Inflammatory Response to Cryptococcus neoformans Infect. Immun., March 1, 2005; 73(3): 1788 - 1796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Yauch, M. K. Mansour, S. Shoham, J. B. Rottman, and S. M. Levitz Involvement of CD14, Toll-Like Receptors 2 and 4, and MyD88 in the Host Response to the Fungal Pathogen Cryptococcus neoformans In Vivo Infect. Immun., September 1, 2004; 72(9): 5373 - 5382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Uezu, K. Kawakami, K. Miyagi, Y. Kinjo, T. Kinjo, H. Ishikawa, and A. Saito Accumulation of {gamma}{delta} T Cells in the Lungs and Their Regulatory Roles in Th1 Response and Host Defense against Pulmonary Infection with Cryptococcus neoformans J. Immunol., June 15, 2004; 172(12): 7629 - 7634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Blackstock and J. W. Murphy Role of Interleukin-4 in Resistance to Cryptococcus neoformans Infection Am. J. Respir. Cell Mol. Biol., January 1, 2004; 30(1): 109 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Biondo, C. Beninati, M. Bombaci, L. Messina, G. Mancuso, A. Midiri, R. Galbo, and G. Teti Induction of T Helper Type 1 Responses by a Polysaccharide Deacetylase from Cryptococcus neoformans Infect. Immun., September 1, 2003; 71(9): 5412 - 5417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Fieschi, S. Dupuis, E. Catherinot, J. Feinberg, J. Bustamante, A. Breiman, F. Altare, R. Baretto, F. Le Deist, S. Kayal, et al. Low Penetrance, Broad Resistance, and Favorable Outcome of Interleukin 12 Receptor {beta}1 Deficiency: Medical and Immunological Implications J. Exp. Med., February 17, 2003; 197(4): 527 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Gracie, S. E. Robertson, and I. B. McInnes Interleukin-18 J. Leukoc. Biol., February 1, 2003; 73(2): 213 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kinjo, K. Kawakami, K. Uezu, S. Yara, K. Miyagi, Y. Koguchi, T. Hoshino, M. Okamoto, Y. Kawase, K. Yokota, et al. Contribution of IL-18 to Th1 Response and Host Defense Against Infection by Mycobacterium tuberculosis: A Comparative Study with IL-12p40 J. Immunol., July 1, 2002; 169(1): 323 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Huang, S. A. McClellan, R. P. Barrett, and L. D. Hazlett IL-18 Contributes to Host Resistance Against Infection with Pseudomonas aeruginosa Through Induction of IFN-{gamma} Production J. Immunol., June 1, 2002; 168(11): 5756 - 5763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Park, B. Hondowicz, M. Kopf, and P. Scott The Role of IL-12 in Maintaining Resistance to Leishmania major J. Immunol., June 1, 2002; 168(11): 5771 - 5777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Singh, S.-i. Kashiwamura, P. Rao, H. Okamura, A. Mukherjee, and V. S. Chauhan The Role of IL-18 in Blood-Stage Immunity Against Murine Malaria Plasmodium yoelii265 and Plasmodium bergheiANKA J. Immunol., May 1, 2002; 168(9): 4674 - 4681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Vallance, W. Deng, L. A. Knodler, and B. B. Finlay Mice Lacking T and B Lymphocytes Develop Transient Colitis and Crypt Hyperplasia yet Suffer Impaired Bacterial Clearance during Citrobacter rodentium Infection Infect. Immun., April 1, 2002; 70(4): 2070 - 2081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Whitman, P. Ravisankar, and A. Daugherty Interleukin-18 Enhances Atherosclerosis in Apolipoprotein E-/- Mice Through Release of Interferon-{gamma} Circ. Res., February 8, 2002; 90 (2): e34 - e38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawakami, Y. Kinjo, K. Uezu, S. Yara, K. Miyagi, Y. Koguchi, T. Nakayama, M. Taniguchi, and A. Saito Monocyte Chemoattractant Protein-1-Dependent Increase of V{alpha}14 NKT Cells in Lungs and Their Roles in Th1 Response and Host Defense in Cryptococcal Infection J. Immunol., December 1, 2001; 167(11): 6525 - 6532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawakami, Y. Kinjo, S. Yara, K. Uezu, Y. Koguchi, M. Tohyama, M. Azuma, K. Takeda, S. Akira, and A. Saito Enhanced Gamma Interferon Production through Activation of Valpha 14+ Natural Killer T Cells by alpha -Galactosylceramide in Interleukin-18-Deficient Mice with Systemic Cryptococcosis Infect. Immun., November 1, 2001; 69(11): 6643 - 6650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Swain Interleukin 18: Tipping the Balance towards a T Helper Cell 1 Response J. Exp. Med., August 6, 2001; 194(3): f11 - f14. [Full Text] [PDF]
|
|
|
|
|
|
L. Del Rio, A. J. Buendia, J. Sanchez, M. C. Gallego, M. R. Caro, N. Ortega, J. Seva, F. J. Pallares, F. Cuello, and J. Salinas Endogenous Interleukin-12 Is Not Required for Resolution of Chlamydophila abortus (Chlamydia psittaci Serotype 1) Infection in Mice Infect. Immun., August 1, 2001; 69(8): 4808 - 4815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Chen, Y. Wei, G. C. Sharp, and H. Braley-Mullen Induction of Experimental Autoimmune Thyroiditis in IL-12-/- Mice J. Immunol., August 1, 2001; 167(3): 1720 - 1727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Whitman, P. Ravisankar, and A. Daugherty Interleukin-18 Enhances Atherosclerosis in Apolipoprotein E-/- Mice Through Release of Interferon-{gamma} Circ. Res., February 8, 2002; 90 (2): e34 - e38. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
