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T Cells Bearing Invariant V6/V1 Induced by Escherichia coli Infection in Mice1
*
Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, and
First Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan;
Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan; and
§
Department of Host Defense, Research Institute for Microbial Disease, Osaka University, Osaka, Japan
We recently reported that the number of 
T cells was
increased after infection with Escherichia coli in
C3H/HeN mice. We here showed that an i.p. injection with native lipid A
derived from E. coli induced an increase of T
cells in the peritoneal cavity of LPS-responsive C3H/HeN mice and,
albeit to a lesser degree, also in LPS-hyporesponsive C3H/HeJ mice. The
purified T cells from C3H/HeN and C3H/HeJ mice expressed a
canonical TCR repertoire encoded by V6-J1/V1-D2-J2 gene
segments and proliferated in response to the native lipid A derived
from E. coli in a TCR-independent manner. The lipid
A-reactive T cells bearing canonical V6/V1 expressed
Toll-like receptor (TLR) 2 mRNA, while TLR4 mRNA was undetectable.
Treatment with a TLR2 anti-sense oligonucleotide resulted in
hyporesponsiveness of the T cells to the native lipid A.
TLR2-deficient mice showed an impaired increase of the T cells
following injection of native lipid A. These results suggest that TLR2
is involved in the activation of canonical V6/V1 T cells by
native E. coli lipid A.
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