| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Division of Molecular Immunology, Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021;
The Immunology Program, Cornell University Weill Graduate School of Medical Sciences, New York, NY 10021; and
Immunex Corporation, Seattle, WA 98101
CD153 (CD30 ligand) is a member of the TNF ligand/cytokine family
expressed on the surface of human B cells. Upon exposure to IL-4, a
critical Ig class switch-inducing cytokine, Ag-activated T cells
express CD30, the CD153 receptor. The observation that dysregulated
IgG, IgA, and/or IgE production is often associated with up-regulation
of T cell CD30 prompted us to test the hypothesis that engagement of B
cell CD153 by T cell CD30 modulates Ig class switching. In this study,
we show that IgD+ IgM+ B cells up-regulate
CD153 in the presence of CD154 (CD40 ligand), IL-4, and B cell Ag
receptor engagement. In these cells, CD153 engagement by an agonistic
anti-CD153 mAb or T cell CD30 inhibits Sµ
S
, SµS
,
and SµS
class switch DNA recombination (CSR). This inhibition
is associated with decreased TNFR-associated factor-2 binding to CD40,
decreased NF-
B binding to the CD40-responsive element of the C3
promoter, decreased I3-C3 germline gene transcription, and
decreased expression of Ku70, Ku80, DNA protein kinase,
switch-associated protein-70, and Msh2 CSR-associated transcripts. In
addition, CD153 engagement inhibits IgG, IgA, and IgE production, and
this effect is associated with reduced levels of B lymphocyte
maturation protein-1 transcripts, and increased binding of B
cell-specific activation protein to the Ig 3' enhancer. These findings
suggest that CD30+ T cells modulate CSR as well as IgG,
IgA, and IgE production by inducing reverse signaling through B cell
CD153.
This article has been cited by other articles:
|
|
 |
|
  M. Sun and P. J. Fink A New Class of Reverse Signaling Costimulators Belongs to the TNF Family J. Immunol., October 1, 2007; 179(7): 4307 - 4312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Shi, J. Mao, G. Yu, J. Zhang, and J. Wu Tumor Vaccine Based on Cell Surface Expression of DcR3/TR6 J. Immunol., April 15, 2005; 174(8): 4727 - 4735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Blazar, R. B. Levy, T. W. Mak, A. Panoskaltsis-Mortari, H. Muta, M. Jones, M. Roskos, J. S. Serody, H. Yagita, E. R. Podack, et al. CD30/CD30 Ligand (CD153) Interaction Regulates CD4+ T Cell-Mediated Graft-versus-Host Disease J. Immunol., September 1, 2004; 173(5): 2933 - 2941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Chtanova, S. G. Tangye, R. Newton, N. Frank, M. R. Hodge, M. S. Rolph, and C. R. Mackay T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells J. Immunol., July 1, 2004; 173(1): 68 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-C. Su, H.-H. Chiu, C.-C. Chang, J.-C. Chen, and S.-M. Hsu CD30 Is Involved in Inhibition of T-Cell Proliferation by Hodgkin's Reed-Sternberg Cells1 Cancer Res., March 15, 2004; 64(6): 2148 - 2152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kirchner, S. Boldt, W. Kolch, S. Haffner, S. Kazak, P. Janosch, E. Holler, R. Andreesen, and G. Eissner LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway J. Leukoc. Biol., February 1, 2004; 75(2): 324 - 331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Shi, Y. Wu, J. Zhang, and J. Wu Death Decoy Receptor TR6/DcR3 Inhibits T Cell Chemotaxis In Vitro and In Vivo J. Immunol., October 1, 2003; 171(7): 3407 - 3414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Younes and M. E. Kadin Emerging Applications of the Tumor Necrosis Factor Family of Ligands and Receptors in Cancer Therapy J. Clin. Oncol., September 15, 2003; 21(18): 3526 - 3534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schaffer, E. C. Kim, X. Wu, H. Zan, L. Testoni, S. Salamon, A. Cerutti, and P. Casali Selective Inhibition of Class Switching to IgG and IgE by Recruitment of the HoxC4 and Oct-1 Homeodomain Proteins and Ku70/Ku86 to Newly Identified ATTT cis-Elements J. Biol. Chem., June 13, 2003; 278(25): 23141 - 23150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhou, A. Saxon, and K. Zhang Human Activation-Induced Cytidine Deaminase Is Induced by IL-4 and Negatively Regulated by CD45: Implication of CD45 as a Janus Kinase Phosphatase in Antibody Diversification J. Immunol., February 15, 2003; 170(4): 1887 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wan, J. Zhang, H. Luo, G. Shi, E. Kapnik, S. Kim, P. Kanakaraj, and J. Wu A TNF Family Member LIGHT Transduces Costimulatory Signals into Human T Cells J. Immunol., December 15, 2002; 169(12): 6813 - 6821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cerutti, H. Zan, E. C. Kim, S. Shah, E. J. Schattner, A. Schaffer, and P. Casali Ongoing In Vivo Immunoglobulin Class Switch DNA Recombination in Chronic Lymphocytic Leukemia B Cells J. Immunol., December 1, 2002; 169(11): 6594 - 6603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Feldhahn, I. Schwering, S. Lee, M. Wartenberg, F. Klein, H. Wang, G. Zhou, S. M. Wang, J. D. Rowley, J. Hescheler, et al. Silencing of B Cell Receptor Signals in Human Naive B Cells J. Exp. Med., November 18, 2002; 196(10): 1291 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Shi, H. Luo, X. Wan, T. W. Salcedo, J. Zhang, and J. Wu Mouse T cells receive costimulatory signals from LIGHT, a TNF family member Blood, October 16, 2002; 100(9): 3279 - 3286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Panus, C. A. Smith, C. A. Ray, T. D. Smith, D. D. Patel, and D. J. Pickup Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: A soluble, secreted CD30 homologue PNAS, June 11, 2002; 99(12): 8348 - 8353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Vinante, A. Rigo, M. T. Scupoli, and G. Pizzolo CD30 triggering by agonistic antibodies regulates CXCR4 expression and CXCL12 chemotactic activity in the cell line L540 Blood, January 1, 2002; 99(1): 52 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. I. Kuzin, J. E. Snyder, G. D. Ugine, D. Wu, S. Lee, T. Bushnell Jr, R. A. Insel, F. M. Young, and A. Bottaro Tetracyclines inhibit activated B cell function Int. Immunol., July 1, 2001; 13(7): 921 - 931. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
